anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) Anticorps

TIMP3 belongs to the TIMP gene family. De plus, nous expédions TIMP3 Kits (93) et TIMP3 Protéines (17) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TIMP3 7078 P35625
TIMP3 25358  
TIMP3 21859 P39876
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Top anti-TIMP3 Anticorps sur anticorps-enligne.fr

Showing 10 out of 215 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of TIMP3 using anti- TIMP3 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat kidney tissue lysates,   Lane 2: NIH3T3 whole cell lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- TIMP3 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for TIMP3 at approximately 24KD. The expected band size for TIMP3 is at 24KD. 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Humain Lapin Inconjugué ELISA, WB 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Humain Lapin Inconjugué ELISA, WB Anti-TIMP3 antibody, Western blotting Lane 1: Recombinant Human TIMP3 Protein 10ng Lane 2: Recombinant Human TIMP3 Protein 5ng Lane 3: Recombinant Human TIMP3 Protein 2.5ng 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-TIMP3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: MCF7 cell lysate WB Suggested Anti-TIMP3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: MCF7 cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-TIMP3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: MCF7 cell lysate WB Suggested Anti-TIMP3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: MCF7 cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB Western blot analysis of TIMP3 expression in HepG2 (A), HeLa (B), NIH3T3 (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from HuvEc cells, using TIMP3 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse liver tissue labeled with Anti-TIMP-3 Polyclonal Antibody (ABIN668361), Unconjugated at 1:100, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse liver tissue labeled with Anti-TIMP-3 Polyclonal Antibody , Unconjugated at 1:100, followed by conjugation to the secondary antibody and DAB staining 100 μL Connectez-vous pour afficher 3 to 7 Days
$329.45
Détails
Humain Lapin Inconjugué EIA, FACS, IHC (p), WB TIMP3 Antibody (Center) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human breast carcinoma reacted with TIMP3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Boeuf (Vache) Lapin PE FACS, IF, IHC (f) 250 μL Connectez-vous pour afficher 3 to 4 Days
$392.62
Détails

anti-TIMP3 Anticorps mieux référencés

  1. Human Polyclonal TIMP3 Primary Antibody pour IF (p), IHC (p) - ABIN668361 : Liu, Cui, Ao, Zhou, Zhou, Yuan, Xiang, Liu, Cao et al.: Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of ... dans Toxicology and applied pharmacology 2011 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal TIMP3 Primary Antibody pour ELISA, WB - ABIN5518878 : Bai, Yi, Li, Sui: Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma. dans World journal of gastroenterology 2007 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal TIMP3 Primary Antibody pour ELISA, WB - ABIN3043541 : Guan, Zhang, Song, Dai: Promoter methylation and expression of TIMP3 gene in gastric cancer. dans Diagnostic pathology 2014 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal TIMP3 Primary Antibody pour CyTOF, FACS - ABIN4899802 : Troeberg, Fushimi, Khokha, Emonard, Ghosh, Nagase: Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 (PubMed)

  5. Human Polyclonal TIMP3 Primary Antibody pour ELISA, ICC - ABIN6265583 : Mao, Du, Yang, Zhang, Peng, Jiang, Zhou: Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro. dans Molecular medicine reports 2018 (PubMed)

  6. Human Monoclonal TIMP3 Primary Antibody pour IHC (p), IHC - ABIN258856 : Jerónimo, Rodrigues, Vilas-Boas, Martins, Bagulho, Real: Hydrogen peroxide regulates angiogenesis-related factors in tumor cells. dans Biochemistry and cell biology = Biochimie et biologie cellulaire 2017 (PubMed)

Plus d’anticorps contre TIMP3 partenaires d’interaction

Human TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. Genetic variation in the TIMP-3 gene may contribute to individual differences in mixture plaque susceptibility in the Han Chinese population.

  2. TIMP3 methylation is a marker for TN tumours and furthermore we showed for the first time that TIMP3 promoter methylation is an epigenetic marker of BRCA1ness tumours.

  3. As a novel CLOCK-dependent diurnal gene, TIMP3 inhibits the expression of inflammatory cytokines that are up-regulated by UV irradiation in human keratinocytes.

  4. miR-21-5p mediates apoptosis by targeting PTEN and TIMP3.

  5. Preliminary studies indicate that baseline MMP3 and TIMP3 concentrations are associated with patient survival and disease-free time

  6. TIMP-3 mRNA expression levels positively correlates with levels of miR-21 in in situ breast carcinomas and negatively in progesterone receptor positive invasive breast carcinomas.

  7. Sphingosine-1-phosphate inhibited cell migration and MMP-2 expression through the upregulation of the tissue inhibitor of metalloproteinase-3 (TIMP-3) expression in human chondrosarcoma cells.

  8. Using global proteomic profiling of brain leptomeningeal arteries, this study revealed that clusterin and tissue inhibitor of metalloproteinases-3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy.

  9. This is the first report of a syndromic Sorsby fundus dystrophy in line with the mouse model uncovering the role of TIMP3 in human lung morphogenesis and functions.

  10. Collectively, these results demonstrated that IL-32alpha upregulates the atheroprotective genes Timp3 and Reck by downregulating microRNA-205 through regulation of the Rprd2-Dgcr8/Ddx5-Dicer1 biogenesis pathway.

  11. MMP-13 may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 is a key modulator of extracellular levels of MMP-13 and its internalization is independent of the levels of ADAMTS-4, -5 and TIMP-3.

  12. Long noncoding RNA DANCR promotes prostate cancer invasion and metastasis through repressing the expression of TIMP2/3

  13. we show that KDM1A promotes cancer metastasis in non-small cell lung cancer cells by repressing TIMP3 (tissue inhibitor of metalloproteinase 3) expression.

  14. Dissecting the interaction between TIMP3 and LRP1 using a synthetic analog of the LRP1 receptor has been reported.

  15. These results implicate TIMP3 as a modulator of cell surface GHR abundance and the ability of GH to promote cellular signaling.

  16. native glycosaminoglycans interact with TIMP-3.

  17. The expression level of LIPC, SLC16A8, and TIMP-3 was significantly associated with age-related macular degeneration pathology.

  18. Levels of miR-221/222 are associated negatively with estrogen receptor in in situ tumors and positively with tissue inhibitor of metalloproteinase 3 TIMP3 messenger RNA expression levels in pure invasive breast cancers.

  19. Electrostatic potential calculations suggested a competition between negatively charged GAGs and highly negatively charged complement-like domains of LRP-1 for the binding to a positively charged area of TIMP-3 as an underlying mechanism.

  20. TIMP3 overexpression after myocardial infarction improves myocardial structural remodeling and function by promoting angiogenesis and inhibiting early proteolysis.

Rabbit TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. The present study demonstrated the ability of 30 and 100 ng/ml TIMP3 to attenuate migration and proliferation, and to inhibit the activity of MMP2, MMP9 and TNFalpha secretion of NA SMCs. In conclusion, TIMP3 may be considered a potential therapeutic drug for use in a novel drugeluting stent, to attenuate the progressive dilation of the aortic NA.

  2. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 and decreased TIMP-3 secretion.

  3. TIMP-3 is downregulated in a distinct subpopulation of atherosclerotic foam cells which have increased MMP-14.

Cow (Bovine) TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. Reactive oxygen species mediate TGF-beta1-induced TIMP-3 gene expression

  2. TIMP3 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.

  3. TIMP3 mRNA expression level was upregulated by multidirectional articular motion.

Xenopus laevis TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. only the N-terminal, but not the C-terminal domain of TIMP-3, results in developmental defects.

  2. metamorphic tail and intestine RNA levels of TIMP-2, MT1-MMP and Gel-A, but not MT3-MMP or TIMP-3, are elevated during periods of cell death and proliferation

Mouse (Murine) TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. Loss of Timp3 enhanced the susceptibility to iron overload-mediated heart and liver injury, suggesting that Timp3 is a key protective molecule against iron-mediated pathology.

  2. Loss of TIMP3 is associated with germinal matrix hemorrhage-intraventricular hemorrhage.

  3. altered cortical and trabecular bone mineralization and increased compositional heterogeneity were found in Timp-3 (-/-) bone, all being indicative of high bone remodeling

  4. In a clinically relevant CADASIL mouse model, we show that exogenous ADAM17 or HB-EGF restores cerebral arterial tone and blood flow responses, and identify upregulated voltage-dependent potassium channel (KV) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3-induced deficits.

  5. TIMP3 promotes normal microvascular endothelial cell barrier function, at least partially, through inhibition of metalloproteinase-dependent disruption of adherens junctions, and septic downregulation of TIMP3 may contribute to septic MVEC barrier dysfunction.

  6. data strongly suggest that TIMP3 has direct neuroprotective effects that can mitigate the deleterious effects associated with TBI, an area with few if any therapeutic options.

  7. Elevated levels of TIMP3 and vitronectin, acting downstream of Notch3(ECD) deposition, play a role in CADASIL, producing divergent influences on early CBF deficits and later white matter lesions.

  8. 4-Hydroxyisoleucine improved insulin resistant-like state in 3T3-L1 adipocytes by targeting TACE/TIMP3 and the insulin signaling pathway.

  9. In a mouse model of prostate cancer, increased tumor growth, proliferation index, increased microvascular density, and invasion was observed in Pten(-/-), Timp3(-/-) prostate tumors compared to Pten(-/-), Timp3(+/+) tumors.

  10. Timp3 status determines p53, p38 and Notch coactivation to instruct hepatic cell fate and transformation.

  11. TIMP2 and TIMP3 play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function

  12. Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3-deficient mice.

  13. lack of TIMP3 increases inflammation and polarizes macrophages towards a more inflammatory phenotype resulting in increased atherosclerosis.

  14. TIMP-3 KO mice exhibit enhanced metabolism, as reflected by a higher body temperature than WT mice, possibly due to increased mitochondrial activity.

  15. TIMP3 protects kidney from damage

  16. TIMP3 reduction is due, at least in part, to increased expression of certain TIMP3-targeting microRNAs in diabetic kidneys compared to healthy controls.

  17. Demonstrate a critical role for TIMP3, among all TIMPs, in preserving arterial remodelling in response to Ang II-induced hypertension.

  18. TIMP-3 functions to moderate the differentiation of macrophages into proinflammatory (M1) cells.

  19. DNA methylation changes were noted in the Timp3 gene during chronic cystitis in a murine model.

  20. Loss of TIMP3 is a hallmark of diabetic nephropathy, causing a concomitant STAT1-dependent and compartment-specific loss of FoxO1 activity.

Pig (Porcine) TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. These results suggest the crucial role of TIMP-3 in successful implantation and embryo survival and indicate the endometrial stromal decidualization-like in pigs.

TIMP3 profil antigène

Profil protéine

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.

Gene names and symbols associated with TIMP3

  • metalloproteinase inhibitor 3 (CpipJ_CPIJ003282) anticorps
  • TIMP metallopeptidase inhibitor 3 (TIMP3) anticorps
  • Metalloproteinase inhibitor 3 (timp3) anticorps
  • TIMP metallopeptidase inhibitor 3 (Timp3) anticorps
  • TIMP metallopeptidase inhibitor 3 L homeolog (timp3.L) anticorps
  • tissue inhibitor of metalloproteinase 3 (Timp3) anticorps
  • HSMRK222 anticorps
  • IMP-3 anticorps
  • K222 anticorps
  • K222TA2 anticorps
  • SFD anticorps
  • Timp-3 anticorps
  • timp3 anticorps
  • timp3-A anticorps

Protein level used designations for TIMP3

metalloproteinase inhibitor 3 , TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) , tissue inhibitor metalloproteinase-3 , TIMP metallopeptidase inhibitor 3 , Metalloproteinase inhibitor 3 , MIG-5 protein , TIMP-3 , protein MIG-5 , tissue inhibitor of metalloproteinases 3 , tissue inhibitor of metalloproteinase-3 , tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) , tissue inhibitor of metalloproteinase 3 , 21 kDa protein of extracellular matrix , tissue inhibitor of metalloproteinases-3

GENE ID SPECIES
6034728 Culex quinquefasciatus
481289 Canis lupus familiaris
100135460 Papio anubis
100196821 Salmo salar
7078 Homo sapiens
100008690 Oryctolagus cuniculus
25358 Rattus norvegicus
282094 Bos taurus
100033947 Equus caballus
396483 Gallus gallus
373596 Xenopus laevis
574381 Macaca mulatta
100217407 Ovis aries
21859 Mus musculus
396775 Sus scrofa
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