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TIMP3 belongs to the TIMP gene family. De plus, nous expédions TIMP3 Kits (98) et TIMP3 Protéines (17) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 215 products:
Human Polyclonal TIMP3 Primary Antibody pour IF (p), IHC (p) - ABIN668361
Liu, Cui, Ao, Zhou, Zhou, Yuan, Xiang, Liu, Cao et al.: Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of ... dans Toxicology and applied pharmacology 2011
Show all 5 Pubmed References
Human Monoclonal TIMP3 Primary Antibody pour IHC (p), IHC - ABIN258856
Jerónimo, Rodrigues, Vilas-Boas, Martins, Bagulho, Real: Hydrogen peroxide regulates angiogenesis-related factors in tumor cells. dans Biochemistry and cell biology = Biochimie et biologie cellulaire 2017
Human Polyclonal TIMP3 Primary Antibody pour ELISA, ICC - ABIN6265583
Mao, Du, Yang, Zhang, Peng, Jiang, Zhou: Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro. dans Molecular medicine reports 2018
Human Monoclonal TIMP3 Primary Antibody pour FACS - ABIN4896675
Mahller, Vaikunth, Ripberger, Baird, Saeki, Cancelas, Crombleholme, Cripe: Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors. dans Cancer research 2008
Human Monoclonal TIMP3 Primary Antibody pour CyTOF, FACS - ABIN4899802
Troeberg, Fushimi, Khokha, Emonard, Ghosh, Nagase: Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
miR (Montrer MLXIP Anticorps)-21-5p mediates apoptosis by targeting PTEN and TIMP3.
Preliminary studies indicate that baseline MMP3 (Montrer MMP3 Anticorps) and TIMP3 concentrations are associated with patient survival and disease-free time
TIMP-3 mRNA expression levels positively correlates with levels of miR (Montrer MLXIP Anticorps)-21 in in situ breast carcinomas and negatively in progesterone receptor (Montrer PGR Anticorps) positive invasive breast carcinomas.
Sphingosine-1-phosphate inhibited cell migration and MMP-2 (Montrer MMP2 Anticorps) expression through the upregulation of the tissue inhibitor of metalloproteinase-3 (TIMP-3) expression in human chondrosarcoma cells.
Using global proteomic profiling of brain leptomeningeal arteries, this study revealed that clusterin (Montrer CLU Anticorps) and tissue inhibitor of metalloproteinases-3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy.
This is the first report of a syndromic Sorsby fundus dystrophy in line with the mouse model uncovering the role of TIMP3 in human lung morphogenesis and functions.
Collectively, these results demonstrated that IL-32alpha upregulates the atheroprotective genes Timp3 and Reck (Montrer RECK Anticorps) by downregulating microRNA-205 through regulation of the Rprd2-Dgcr8 (Montrer DGCR8 Anticorps)/Ddx5 (Montrer DDX5 Anticorps)-Dicer1 (Montrer DICER1 Anticorps) biogenesis pathway.
MMP-13 (Montrer MMP13 Anticorps) may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 (Montrer LRP1 Anticorps) is a key modulator of extracellular levels of MMP-13 (Montrer MMP13 Anticorps) and its internalization is independent of the levels of ADAMTS-4 (Montrer ADAMTS4 Anticorps), -5 and TIMP-3.
Long noncoding RNA DANCR promotes prostate cancer invasion and metastasis through repressing the expression of TIMP2 (Montrer TIMP2 Anticorps)/3
we show that KDM1A (Montrer KDM1A Anticorps) promotes cancer metastasis in non-small cell lung cancer cells by repressing TIMP3 (tissue inhibitor of metalloproteinase 3) expression.
The present study demonstrated the ability of 30 and 100 ng/ml TIMP3 to attenuate migration and proliferation, and to inhibit the activity of MMP2 (Montrer MMP2 Anticorps), MMP9 (Montrer MMP9 Anticorps) and TNFalpha (Montrer TNF Anticorps) secretion of NA SMCs. In conclusion, TIMP3 may be considered a potential therapeutic drug for use in a novel drugeluting stent, to attenuate the progressive dilation of the aortic NA.
Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 (Montrer MMP1 Anticorps) and decreased TIMP-3 secretion.
TIMP-3 is downregulated in a distinct subpopulation of atherosclerotic foam cells which have increased MMP-14 (Montrer MMP14 Anticorps).
Reactive oxygen species mediate TGF-beta1 (Montrer TGFB1 Anticorps)-induced TIMP-3 gene expression
TIMP3 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.
TIMP3 mRNA expression level was upregulated by multidirectional articular motion.
only the N-terminal, but not the C-terminal domain of TIMP-3, results in developmental defects.
metamorphic tail and intestine RNA levels of TIMP-2 (Montrer TIMP2 Anticorps), MT1-MMP (Montrer MMP14 Anticorps) and Gel-A, but not MT3-MMP (Montrer MMP24 Anticorps) or TIMP-3, are elevated during periods of cell death and proliferation
Loss of TIMP3 is associated with germinal matrix hemorrhage-intraventricular hemorrhage.
altered cortical and trabecular bone mineralization and increased compositional heterogeneity were found in Timp-3 (-/-) bone, all being indicative of high bone remodeling
In a clinically relevant CADASIL (Montrer NOTCH3 Anticorps) mouse model, we show that exogenous ADAM17 (Montrer ADAM17 Anticorps) or HB-EGF (Montrer HBEGF Anticorps) restores cerebral arterial tone and blood flow responses, and identify upregulated voltage-dependent potassium channel (Montrer KCNAB2 Anticorps) (KV) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3-induced deficits.
TIMP3 promotes normal microvascular endothelial cell barrier function, at least partially, through inhibition of metalloproteinase-dependent disruption of adherens junctions, and septic downregulation of TIMP3 may contribute to septic MVEC barrier dysfunction.
data strongly suggest that TIMP3 has direct neuroprotective effects that can mitigate the deleterious effects associated with TBI, an area with few if any therapeutic options.
Elevated levels of TIMP3 and vitronectin (Montrer VTN Anticorps), acting downstream of Notch3 (Montrer NOTCH3 Anticorps)(ECD (Montrer ECD Anticorps)) deposition, play a role in CADASIL (Montrer NOTCH3 Anticorps), producing divergent influences on early CBF (Montrer CEBPZ Anticorps) deficits and later white matter lesions.
4-Hydroxyisoleucine improved insulin (Montrer INS Anticorps) resistant-like state in 3T3-L1 adipocytes by targeting TACE (Montrer ADAM17 Anticorps)/TIMP3 and the insulin (Montrer INS Anticorps) signaling pathway.
In a mouse model of prostate cancer, increased tumor growth, proliferation index, increased microvascular density, and invasion was observed in Pten(-/-), Timp3(-/-) prostate tumors compared to Pten(-/-), Timp3(+/+) tumors.
Timp3 status determines p53 (Montrer TP53 Anticorps), p38 (Montrer CRK Anticorps) and Notch (Montrer NOTCH1 Anticorps) coactivation to instruct hepatic cell fate and transformation.
TIMP2 (Montrer TIMP2 Anticorps) and TIMP3 play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function
These results suggest the crucial role of TIMP-3 in successful implantation and embryo survival and indicate the endometrial stromal decidualization-like in pigs.
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
metalloproteinase inhibitor 3
, TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)
, tissue inhibitor metalloproteinase-3
, TIMP metallopeptidase inhibitor 3
, Metalloproteinase inhibitor 3
, MIG-5 protein
, protein MIG-5
, tissue inhibitor of metalloproteinases 3
, tissue inhibitor of metalloproteinase-3
, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
, tissue inhibitor of metalloproteinase 3
, 21 kDa protein of extracellular matrix
, tissue inhibitor of metalloproteinases-3