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Tumor necrosis factor (TNF\; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). De plus, nous expédions TRAF7 Protéines (3) et et beaucoup plus de produits pour cette protéine.
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Horse (Equine) Polyclonal TRAF7 Primary Antibody pour IP, WB - ABIN269571
Zotti, Uva, Ferravante, Vessichelli, Scudiero, Ceccarelli, Vito, Stilo: TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation. dans The Journal of biological chemistry 2011
TRAF7 is involved in signal transduction pathways that lead either to activation or repression of NF-kappaB (Montrer NFKB1 Anticorps) transcription factor.
These results suggest a new mechanism by which MyoD1 (Montrer MYOD1 Anticorps) function is coupled to NF-kappaB (Montrer NFKB1 Anticorps) activity through Traf7, regulating the balance between cell cycle progression and differentiation during myogenesis.
TRAF7 negatively regulates c-Myb (Montrer MYB Anticorps) activity by sequestering c-Myb (Montrer MYB Anticorps) to the cytosol via sumoylation.
TRAF7 mutations icause intraneural perineuriomas.
TRAF7 is a direct target of miR (Montrer MLXIP Anticorps)-126 in human umbilical cord vascular endothelial cells.
Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 (Montrer TP53 Anticorps) in breast cancer.
The findings of this study suggested an essential contribution of combined KLF4 (Montrer KLF4 Anticorps) K409Q and TRAF7 mutations in the genesis of secretory meningioma and demonstrate a role for TRAF7 alterations in other non-NF2 (Montrer NF2 Anticorps) meningiomas.
Nearly one-fourth of all meningiomas have mutations in TRAF7.
an important role for TRAF7 in the activation of JNK (Montrer MAPK8 Anticorps) following TNFalpha (Montrer TNF Anticorps) stimulation and involvement of this protein in regulating the turnover of c-FLIP (Montrer CFLAR Anticorps)
this study identifies TRAF7 as a NEMO (Montrer IKBKG Anticorps)- and p65 (Montrer GORASP1 Anticorps)-interacting molecule and brings important information on the ubiquitination events that control NF-kappaB (Montrer NFKB1 Anticorps) transcriptional activity.
TRAF7 potentiates MEKK3 (Montrer MAP3K3 Anticorps)-induced AP1 (Montrer FOSB Anticorps) and CHOP (Montrer DDIT3 Anticorps) activation and induces apoptosis
Tumor necrosis factor (TNF\; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs\; a coiled-coil (leucine zipper) motif\; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.
TNF receptor-associated factor 7
, ring finger and WD repeat domain 1
, E3 ubiquitin-protein ligase TRAF7
, e3 ubiquitin-protein ligase TRAF7-like
, RING finger and WD repeat-containing protein 1
, RING finger protein 119