anti-Taspase, Threonine Aspartase, 1 (TASP1) Anticorps

TASP1 encodes an endopeptidase that cleaves specific substrates following aspartate residues. De plus, nous expédions Taspase, Threonine Aspartase, 1 Protéines (8) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TASP1 75812 Q8R1G1
TASP1 311468  
TASP1 55617 Q9H6P5
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Top anti-Taspase, Threonine Aspartase, 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 45 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-TASP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: MCF7 cell lysate WB Suggested Anti-TASP1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: MCF7 cell lysate  TASP1 is supported by BioGPS gene expression data to be expressed in MCF7 100 μL 2 to 3 Days
$289.00
Détails
Poulet Lapin Inconjugué WB 100 μL 11 to 14 Days
$551.83
Détails
Humain Souris Inconjugué WB 100 μL 11 to 14 Days
$522.50
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of TASP1 C-term polyclonal antibody in mouse kidney tissue lysates. Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with hTASP1-C-term , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL 2 to 3 Days
$515.63
Détails
Humain Souris Inconjugué WB Western Blot analysis of TASP1 expression in transfected 293T cell line by TASP1 MaxPab polyclonal antibody.Lane 1: TASP1 transfected lysate(46.2 KDa).Lane 2: Non-transfected lysate. 50 μL 11 to 12 Days
$440.00
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of mouse kidney, using TASP1 antibody (ABIN5972786). 100 μL 11 to 16 Days
$426.40
Détails
Humain Lapin Inconjugué WB TASP1 antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Détails
Humain Lapin APC IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Détails
Humain Lapin Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Détails

anti-Taspase, Threonine Aspartase, 1 Anticorps mieux référencés

  1. Human Polyclonal TASP1 Primary Antibody pour IHC (p), ELISA - ABIN543416 : Hsieh, Cheng, Korsmeyer: Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. dans Cell 2003 (PubMed)

Plus d’anticorps contre Taspase, Threonine Aspartase, 1 partenaires d’interaction

Mouse (Murine) Taspase, Threonine Aspartase, 1 (TASP1) interaction partners

  1. Upon loss of taspase1, MLL1 association with chromatin is markedly increased due to the stabilization of its unprocessed version, and this stabilization of the uncleaved MLL1 can result in the displacement of MLL chimeras from chromatin in leukemic cells

  2. Taspase1 deficiency disrupts the expression of cyclins and proliferation of HER2+ breast cancer cells.

  3. TFIIA is the principal TASP1 substrate that orchestrates craniofacial morphogenesis.

  4. Taspase1 cleaves a ubiquitously expressed GTF (TFIIA) to enable tissue-specific (testis) transcription, meeting the demand for sophisticated regulation of distinct subsets of genes in higher organisms.

  5. TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha

  6. This paper describes the quintessential function of Taspase1 in orchestrating cell cycle progression.

Human Taspase, Threonine Aspartase, 1 (TASP1) interaction partners

  1. Taspase 1 processing promotes TFIIA's nuclear accumulation by evolutionary conserved nuclear export signal (NES, amino acids 21VINDVRDIFL30) masking, and modulates its transcriptional activity.

  2. Proteolytic processing of TFIIA by Taspase1 was found to mask evolutionary conserved nuclear export signal, thereby promoting nuclear localization and transcriptional activation of TFIIA target genes, such as CDKN2A.

  3. Studies indicate that threonine Aspartase1 (Taspase1) is overexpressed in numerous liquid and solid malignancies and was characterized as a 'non-oncogene addiction' protease.

  4. simultaneous expression of the leukemogenic AF4-MLL and dnTASP1 causes the disappearance of the leukemogenic oncoprotein, because the uncleaved AF4-MLL protein (328 kDa) is subject to proteasomal degradation.

  5. Our results provide first evidence that Taspase1 processing affects TFIIA regulation of TFIID and suggest that Taspase1 processing of TFIIA is required to establish INR-selective core promoter activity in the presence of NC2.

  6. inefficient heterodimerization appears to be the mechanism by which inactive Taspase1 variants fail to inhibit wild type Taspase1's activity in trans.

  7. Taspase1 appears to exploit the nuclear export activity of importin-alpha/nucleophosmin to gain transient access to the cytoplasm required to also cleave its cytoplasmic substrates.

  8. Cell-based analysis of structure-function activity of threonine aspartase 1.

  9. Taspase1 is overexpressed in primary human cancers, and deficiency of Taspase1 in cancer cells not only disrupts proliferation but also enhances apoptosis.

  10. purification and cloning of threonine aspartase 1 responsible for cleaving MLL; RNAi-mediated knockdown of Taspase1 results in the appearance of unprocessed MLL and the loss of proper HOX gene expression

  11. Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo.

  12. TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha

Taspase, Threonine Aspartase, 1 (TASP1) profil antigène

Profil protéine

This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Gene names and symbols associated with TASP1

  • taspase, threonine aspartase 1 (Tasp1) anticorps
  • taspase 1 (Tasp1) anticorps
  • taspase 1 (TASP1) anticorps
  • 4930485D02Rik anticorps
  • AW986064 anticorps
  • C20orf13 anticorps
  • dJ585I14.2 anticorps
  • RGD1308591 anticorps

Protein level used designations for TASP1

taspase-1 , threonine aspartase 1 , taspase 1

GENE ID SPECIES
75812 Mus musculus
311468 Rattus norvegicus
55617 Homo sapiens
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