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TEX11 is X-linked and is expressed in only male germ cells. De plus, nous expédions Testis Expressed 11 Anticorps (31) et et beaucoup plus de produits pour cette protéine.
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Through the translational regulation of novel RNA targets SMC1B (Montrer SMC1B Protéines) and TEX11, DAZL (Montrer DAZL Protéines) may have a key role in regulating chromosome cohesion and DNA recombination; two processes fundamental in determining oocyte quality and whose establishment in foetal life may support lifelong fertility.
TEX11 mutations, including frameshift and splicing acceptor site mutations, cause infertility in 1% of non-obstructive azoospermic men.
hemizygous TEX11 mutations were a common cause of meiotic arrest and azoospermia in infertile men
TEX11 was specifically expressed in human testis.
Tex11 regulates genome-wide recombination rates in both sexes in a dosage-dependent manner. An intronless autosomal Tex11 transgene functionally substitutes for the X-linked Tex11 gene, providing genetic evidence for the X-to-autosomal retrotransposition evolution phenomenon.
mouse spermatogonial stem cells expressed Tex11, Hpip (Montrer TNFRSF12A Protéines), and Esr2 (Montrer ESR2 Protéines) but not Esr1 (Montrer ESR1 Protéines), and in cultured cells, TEX11 competed with Esr2 (Montrer ESR2 Protéines) for binding to HPIP (Montrer TNFRSF12A Protéines).
Tex11 forms discrete foci on meiotic chromosomes. Tex11 is essential for meiosis and fertility in males. Tex11 promotes both chromosomal synapsis and crossover formation in mice and may link these two meiotic processes by interacting with Sycp2 in vivo.
Zip4h (Tex11), a male germ cell specific X-linked gene was isolated. Zip4h(-/Y) mutant mice were fertile. Analysis of spermatocytes revealed a delay in meiotic double strand break repair and decreased crossover formation.
Tex11 was first identified from mouse spermatogonia and was specifically expressed in mouse testis.
This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
testis expressed sequence 11
, testis-expressed sequence 11 protein
, testis expressed gene 11
, protein ZIP4 homolog