Thiopurine S-Methyltransferase (TPMT) Kits ELISA

TPMT encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. De plus, nous expédions TPMT Anticorps (105) et TPMT Protéines (26) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
TPMT 22017 O55060
TPMT 7172 P51580
TPMT 690050  
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Humain 0.113 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests 13 to 16 Days
$736.84
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  96 Tests 15 to 18 Days
$1,029.60
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  96 Tests 15 to 18 Days
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Plus Kits ELISA pour TPMT partenaires d'interaction

Mouse (Murine) Thiopurine S-Methyltransferase (TPMT) interaction partners

  1. With the significant mitigation of TPMT wild type-expressing cells to cisplatin cytotoxicity, findings demonstrate a drug-gene interaction between increased TPMT activity and decreased susceptibility to cisplatin-induced toxicity of inner ear cells.

  2. These findings support the notion that germline polymorphisms in Tpmt affect not only host tissue toxicity but also antitumor effectiveness.

  3. suggestion that differential mouse TPMT activity is due to variation in mRNA expression

Human Thiopurine S-Methyltransferase (TPMT) interaction partners

  1. The stepwise evolution of TPMT*3 alleles from *3C to *3A, with increasing number of B motifs in the VNTR region.

  2. TPMT has a role in methylation of selenium compounds

  3. Frequency of TPMT alleles increases the efficacy of leukemia treatment. Thus, TPMT genotyping can be useful for optimizing 6-MP therapy.

  4. In our study patients even with wild type TPMT genotype (17.5%) developed myelosuppression underscoring the importance of TPMT mutation as the only factor contributing to myelosuppression

  5. Regular blood tests are necessary on thiopurine therapy despite normal thiopurine S-methyltransferase genotype because of the risk of myelosuppression. The four most common variant alleles were identified in routine genotyping only, therefore most likely rare variant allele(s) or polymorphism of other enzymes involved in thiopurine metabolism account for the aforementioned four cases with profound bone marrow suppression.

  6. The presence of *2, *3A, *3B and *3C mutations were determined, and the relationship between genotype and incidence of adverse events related to the drug was analyzed.Nine carried at least one non-functional allele. Among the eighteen patients who initiated treatment with azathioprine, toxicity was detected in 3 cases: 2 mild events were observed in patients with normal genotype, and one serious was a homozygous patient.

  7. TPMT and NUDT15 genes are both related to mercaptopurine intolerance in acute lymphoblastic leukaemia patients from Uruguay.

  8. Mutation rate of NUDT15 in Chinese inflammatory bowel disease patients is higher than that of TPMT. NUDT15 polymorphism is a better predictor for AZA-induced leukopenia than TPMT polymorphism.

  9. In Mexican patients, mutant alleles were detected in 6.2 and 5.2% of systemic lupus erythematosus and rheumatoid arthritis cases, respectively.

  10. TPMT*3C affects TPMT activity in Chinese patients with neuromyelitis optica spectrum disorders.

  11. Patients also developed infection who mostly (71%) needed hospitalization. None of the studied G238C, G460A and A719G TPMT variant alleles were detected. Infections and febrile neutropenia were common causes of 6-PM dose modification and interruption.

  12. ANCA associated vasculitis (AAV) patients treated with cyclophosphamide induction and azathioprine maintenance therapy were included and followed for 60 months. TPMT genotype and activity were not independent predictors of relapse, and could not predict leukopenia or other adverse effects from azathioprine.

  13. Results show no association between TPMT or COMT single-nucleotide polymorphisms and cisplatin-induced ototoxicity.

  14. Of the 14 patients intolerant to thiopurines, NGS identified deleterious TPMT variants in 5 individuals whereas the biochemical test identified 8 individuals as intolerant (sensitivity 35.7% and 57.14%; specificity 93.75% and 50% respectively). SKAT-O test identified a significant association between MOCOS gene and TPMT activity (p = 0.0015), not previously reported.

  15. A statistically significant correlation between the presence of the G460A mutation and the development of leucopenia after the administration of thiopurines was observed.

  16. genetic association studies in cohort in Denmark: Data suggest that standard immunosuppression treatment failure in patients with autoimmune hepatitis is not associated with thiopurine S-methyltransferase genetic variants or HLA-DRB1*03 genotype in the population studied. (HLA-DRB1 = major histocompatibility complex class II DR beta 1)

  17. This article reviews the thiopurine pharmacogenetics and the methods applied in common practice to evaluate patient's TPMT status. [review]

  18. study aimed to determine the relationship between thiopurine metabolite levels and therapeutic response, and to investigate the association of NUDT15, TPMT, and thiopurine metabolites with leukopenia in patients with CD

  19. TPMT*3C is overrepresented in acute lymphoblastic leukemia (ALL) cases in comparison with non-ALL group

  20. TMPT polymorphisms are associated with 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia.

TPMT profil antigène

Antigen Summary

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.

Gene names and symbols associated with TPMT

  • thiopurine S-methyltransferase L homeolog (tpmt.L) anticorps
  • thiopurine S-methyltransferase, tandem duplicate 2 (tpmt.2) anticorps
  • thiopurine S-methyltransferase TpmT (tpmT) anticorps
  • thiopurine S-methyltransferase (MCA0794) anticorps
  • thiopurine S-methyltransferase (Pnap_4948) anticorps
  • thiopurine S-methyltransferase (Hhal_1383) anticorps
  • thiopurine S-methyltransferase (TK90_1044) anticorps
  • thiopurine S-methyltransferase (Slit_1144) anticorps
  • thiopurine S-methyltransferase (Tint_0842) anticorps
  • Thiopurine S-methyltransferase (Fbal_3334) anticorps
  • thiopurine S-methyltransferase (Celly_3188) anticorps
  • thiopurine S-methyltransferase (Weevi_1737) anticorps
  • Thiopurine S-methyltransferase (Psefu_2696) anticorps
  • Thiopurine S-methyltransferase (Metme_3860) anticorps
  • thiopurine methyltransferase (Tpmt) anticorps
  • thiopurine S-methyltransferase (TPMT) anticorps
  • thiopurine S-methyltransferase (Tpmt) anticorps
  • AW106912 anticorps
  • MGC84277 anticorps
  • NHLRC1 anticorps

Protein level used designations for TPMT

thiopurine S-methyltransferase , Thiopurine S-methyltransferase , S-adenosyl-L-methionine:thiopurine S-methyltransferase , thiopurine methyltransferase , NHL repeat containing 1

GENE ID SPECIES
447769 Xenopus laevis
573111 Danio rerio
1168449 Shewanella oneidensis MR-1
3104309 Methylococcus capsulatus str. Bath
4685796 Polaromonas naphthalenivorans CJ2
4711327 Halorhodospira halophila SL1
8806802 Thioalkalivibrio sp. K90mix
8891817 Sideroxydans lithotrophicus ES-1
9151573 Thiomonas intermedia K12
9772187 Ferrimonas balearica DSM 9799
10265228 Cellulophaga lytica DSM 7489
10282995 Weeksella virosa DSM 16922
10657285 Pseudomonas fulva 12-X
10673875 Methylomonas methanica MC09
22017 Mus musculus
7172 Homo sapiens
403536 Canis lupus familiaris
511644 Bos taurus
690050 Rattus norvegicus
493759 Felis catus
100034066 Equus caballus
100009411 Oryctolagus cuniculus
471863 Pan troglodytes
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