Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) Protéines (TFPI)

TFPI encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation.

afficher tous les protéines Gène GeneID UniProt
Souris TFPI TFPI 21788 O54819
Humain TFPI TFPI 7035 P10646
Rat TFPI TFPI 29436 Q02445
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Top TFPI Protéines sur anticorps-enligne.fr

Showing 10 out of 34 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Human Cells Humain His tag 10 μg Connectez-vous pour afficher 20 to 21 Days
$250.80
Détails
Human Cells Souris His tag 10 μg Connectez-vous pour afficher 20 to 21 Days
$250.80
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$5,960.83
Détails
HEK-293 Cells Humain His tag 10 μg Connectez-vous pour afficher 2 to 3 Days
$205.00
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$5,960.83
Détails
Escherichia coli (E. coli) Humain GST tag Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) (AA 29-280), (partial) protein (GST tag) 50 μg Connectez-vous pour afficher 13 to 16 Days
$242.00
Détails
Escherichia coli (E. coli) Humain His tag,GST tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$672.00
Détails
HEK-293 Cells Humain Biotin,His tag Biotinylated Human TFPI on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%. 200 μg Connectez-vous pour afficher 2 to 3 Days
$1,375.00
Détails
Escherichia coli (E. coli) Lapin His tag,GST tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$736.00
Détails
Levure Lapin His tag Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) (AA 25-300) protein (His tag) 500 μg Connectez-vous pour afficher 60 to 71 Days
$1,155.00
Détails

TFPI Protéines mieux référencés

  1. Human TFPI Protein expressed in Escherichia coli (E. coli) - ABIN1080946 : Gamperl, Plattfaut, Freund, Quecke, Theophil, Gieseler: Extracellular vesicles from malignant effusions induce tumor cell migration: inhibitory effect of LMWH tinzaparin. dans Cell biology international 2016 (PubMed)

  2. Human TFPI Protein expressed in Escherichia coli (E. coli) - ABIN2123670 : Ranasinghe, Duke, Harvie, McManus: Kunitz-type protease inhibitor as a vaccine candidate against schistosomiasis mansoni. dans International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2017 (PubMed)

  3. Human TFPI Protein expressed in Human Cells - ABIN2003062 : Broze, Warren, Novotny, Higuchi, Girard, Miletich: The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action. dans Blood 1988 (PubMed)
    Show all 5 Pubmed References

Plus protéines pour Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) partenaires d'interaction

Mouse (Murine) Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) interaction partners

  1. endogenous TFPI from vascular smooth muscle cells inhibited ferric chloride-induced arterial thrombosis without causing hemostatic effects

  2. TFPI-1 interacts with AMOT (Montrer AMOT Protéines), which led to a decrease in the phosphorylation of YAP (Montrer YAP1 Protéines) and further increased the genes expression of the proliferation and migration involved. Our results further confirmed that atherosclerosis was a localized disease.

  3. Results suggest that endothelial cell-anchored TFPI controls lung tumor metastasis, and does so largely through the inhibition of local TF-induced thrombin (Montrer F2 Protéines) generation and the regulation of the lung microenvironment in mice.

  4. Data argue against an important role for endogenous TFPI in the antibacterial, inflammatory and procoagulant response during pneumococcal pneumonia.

  5. TFPI has an anti-proliferative role in TNF-alpha (Montrer TNF Protéines) stimulated-VSMCs at least partly by interfering with the MCP-3 (Montrer CCL7 Protéines)/CCR2 (Montrer CCR2 Protéines) pathway and then via suppression of the ERK1/2 and PI3K/AKT (Montrer AKT1 Protéines) signaling pathways

  6. Results demonstrate that TFPI physiologically modulates thrombin (Montrer F2 Protéines)-dependent platelet activation in a manner that is required for successful embryonic development

  7. Tissue factor (Montrer F3 Protéines) plays a hitherto unreported role in the generation of macrophage migratory inhibitory factor by vascular smooth muscle cells in atherosclerosis-prone ApoE (Montrer APOE Protéines)(-/-) mice.

  8. The increased plasmin (Montrer PLG Protéines) generation during the early stages of sepsis could cleave/inactivate TFPI and thus lead to thrombotic complications.

  9. structural features within residues of the 39-loop contribute to the resistance of FIXa (Montrer ETFB Protéines) to inhibition by plasma inhibitors ZPI (Montrer SERPINA10 Protéines) and TFPI.

  10. PAK1 (Montrer PAK1 Protéines) negatively regulates the expression of TFPI and additionally contributes to increased TF activity.

Human Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) interaction partners

  1. Patients with early onset preeclampsia are characterised by an attenuated coagulation response characterised by reduced thrombin (Montrer F2 Protéines) generation stimulated by low-dose TF and elevated plasma TFPI activity.

  2. Developed functional protein S assays that measure both the activated protein C (Montrer PROC Protéines)- and TFPI-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation.

  3. These data indicate that both isoforms of TFPI are present in advanced plaques and that anti-inflammatory M2 macrophages may be a potential source of TFPI.

  4. Among the various candidate genes involved in acute rejection, CD47 (Montrer CD47 Protéines) inhibits monocyte/macrophage-mediated phagocytosis by identifying the CD47 (Montrer CD47 Protéines) signal regulatory protein alpha (SIRP (Montrer SIRPA Protéines)-alpha) as self/non-self. Tissue factor pathway inhibitor (TFPI) is involved in the regulation of the coagulation pathway and is able to bind to another ligand of CD47 (Montrer CD47 Protéines), thrombospondin-1 (TSP-1 (Montrer THBS1 Protéines)).

  5. Tissue Factor Pathway Inhibitor Gene Polymorphism is associated with response to therapy in Colorectal Cancer.

  6. For the first time, we show that a TFPI variant is significantly associated with fibrinogen levels and risk of coronary artery disease.

  7. miR (Montrer MLXIP Protéines)-27a/b and miR (Montrer MLXIP Protéines)-494 regulate TFPIalpha expression; there may be a role of these miRNAs in the estrogen-mediated downregulation of TFPIalpha

  8. Genetic variations of the TFPI genes seem to be related with coronary artery disease, which likely cooperate with metabolic risk factor (diabetes mellitus) and play critical roles in the pathogenesis of coronary artery disease in Han Chinese.

  9. Cleavage of FV at Arg(1545) , which abolishes the anticoagulant properties of FV and commits FV to the procoagulant pathway, is inhibited by binding of the TFPIalpha C-terminus to the FV acidic region

  10. The aim of this study was to evaluate the concentration of TF and its inhibitor TFPI in blood plasma, the impact of traditional and non-traditional cardiovascular risk factors on their concentration and the impact of both markers of haemostasis on the severity of subclinical atherosclerosis.

Rabbit Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) interaction partners

  1. Upregulated TF expression and increased plasma TF level during reperfusion period, reduced plasma TFPI-1 level during reperfusion period.

Cow (Bovine) Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) interaction partners

  1. structural features within residues of the 39-loop contribute to the resistance of FIXa (Montrer ETFB Protéines) to inhibition by plasma inhibitors ZPI (Montrer SERPINA10 Protéines) and TFPI.

Profil protéine TFPI

Profil protéine

This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.

Gene names and symbols associated with TFPI

  • tissue factor pathway inhibitor (Tfpi)
  • tissue factor pathway inhibitor (TFPI)
  • A630013F22Rik Protéine
  • AW552122 Protéine
  • EPI Protéine
  • LACI Protéine
  • TFI Protéine
  • TFPI1 Protéine

Protein level used designations for TFPI

extrinsic pathway inhibitor , lipoprotein-associated coagulation inhibitor , uncharacterized protein LOC100155068 , anti-convertin , tissue factor pathway inhibitor , EPI , LACI

GENE ID SPECIES
21788 Mus musculus
100155068 Sus scrofa
7035 Homo sapiens
29436 Rattus norvegicus
100009401 Oryctolagus cuniculus
403921 Canis lupus familiaris
508763 Bos taurus
423989 Gallus gallus
101120391 Ovis aries
613026 Macaca mulatta
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