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TTN encodes a large abundant protein of striated muscle. De plus, nous expédions Titin Kits (21) et Titin Protéines (6) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 57 products:
Human Polyclonal Titin Primary Antibody pour IHC, IHC (p) - ABIN4359867
Seki, Yuasa, Kusumoto, Kunitomi, Saito, Tohyama, Yae, Kishino, Okada, Hashimoto, Takei, Egashira, Kodaira, Kuroda, Tanaka, Okata, Suzuki, Murata, Fujita, Fukuda: Generation and characterization of functional cardiomyocytes derived from human T cell-derived induced pluripotent stem cells. dans PLoS ONE 2014
Show all 2 Pubmed References
Human Monoclonal Titin Primary Antibody pour IF, IHC (p) - ABIN563282
Choi, Park, Yi, Kim: Novel Mutation of the GNE Gene Presenting Atypical Mild Clinical Feature: A Korean Case Report. dans Annals of rehabilitation medicine 2015
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.
, rhabdomyosarcoma antigen MU-RMS-40.14
, titin protein homolog