anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) Anticorps

TOP2B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. De plus, nous expédions Topoisomerase (DNA) II beta 180kDa Kits (14) et Topoisomerase (DNA) II beta 180kDa Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TOP2B 21974 Q64511
TOP2B 361100  
TOP2B 7155 Q02880
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Showing 10 out of 61 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB <b>WB Suggested Anti-TOP2B Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>Jurkat cell lysate WB Suggested Anti-TOP2B <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: Jurkat cell lysate <br /> TOP2B is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Connectez-vous pour afficher 2 to 3 Days
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), IP, WB Western Blot and Immunoprecipitation: Topo II Beta Antibody [ABIN251526] - Detection of Human Topo II Beta by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) and 293T (T, 50 mcg) cells. Antibodies: Affinity purified rabbit anti- Topo II Beta antibody ABIN251526 used for WB at 0.04 mcg/ml (A) and 0.1 mcg/ml (B) and used for IP at 3 mcg/mg lysate (B). Topo II Beta was also immunoprecipitated by another rabbit anti-Topo II Beta antibody and  ABIN251525, which recognize upstream epitopes. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B). Immunohistochemistry-Paraffin: TOP2B Antibody [ABIN2515262] - FFPE section of human small cell lung cancer. Affinity purified rabbit anti-Topo II Beta used at a dilution of 1:250. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
Humain Lapin Inconjugué IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using TOP2B Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TOP2B Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 2 to 3 Days
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), SimWes, WB Immunocytochemistry/Immunofluorescence: TOP2B Antibody  - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm. Immunohistochemistry-Paraffin: TOP2B Antibody  - Staining of human pancreas shows moderate nuclear positivity. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
Humain Souris Inconjugué BI, IF, WB Western blot analysis of Topo IIbeta on a Jurkat lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the Topo IIbeta antibody. Immunofluorescent staining of A549 cells. Cells were seeded in a 96 well imaging plate at ~ 10 000 cells per well. After overnight incubation, cells were stained using the methanol fix/perm protocol and the anti-Topisomerase IIbeta antibody. The second step reagent was FITC goat anti mouse Ig. The image was taken on a Pathway 850 imager using a 20x objective. This antibody also stained HeLa and U2OS cells and can be used with either fix/perm protocol. 50 μg Connectez-vous pour afficher 6 to 8 Days
Souris Lapin Inconjugué ICC, IHC, IP, WB Western Blot; Sample: Human K562 cell lysate; Primary Ab: 2µg/mL Rabbit Anti-Mouse TOP2b Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg Connectez-vous pour afficher 13 to 16 Days
Humain Lapin Inconjugué IP, IHC (p), WB IP Image Topoisomerase II beta antibody immunoprecipitates Topoisomerase II beta protein in IP experiments. IP Sample: HeLa whole cell lysate/extract A. 40 μg HeLa whole cell lysate/extract B. Control with 2 μg of preimmune rabbit IgG C. Immunoprecipitation of Topoisomerase II beta protein by 2 μg of Topoisomerase II beta antibody , 5% SDS-PAGE The immunoprecipitated Topoisomerase II beta protein was detected by Topoisomerase II beta antibody , diluted at 1:1000. EasyBlot anti-rabbit IgG  was used as a secondary reagent. WB Image Sample (30 ug of whole cell lysate) A: Jurkat 5% SDS PAGE antibody diluted at 1:3000 100 μL Connectez-vous pour afficher 1 to 2 Days
Roussette (Chauve-souris) Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 7 to 9 Days
Chien Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 7 to 9 Days
Humain Lapin Inconjugué IHC (p), WB 0.1 mg Connectez-vous pour afficher 6 to 8 Days

TOP2B Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Mouse (Murine)

Rat (Rattus)

Human , , ,

anti-Topoisomerase (DNA) II beta 180kDa Anticorps mieux référencés

  1. Human Monoclonal TOP2B Primary Antibody pour BI, IF - ABIN968562 : Brown, Holden, Rahn, Perkins: Immunohistochemical staining for DNA topoisomerase IIa in Hodgkin's disease. dans American journal of clinical pathology 1998 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal TOP2B Primary Antibody pour BI, IF - ABIN968561 : Herzog, Holmes, Tuschong, Ganapathi, Zwelling: Absence of topoisomerase IIbeta in an amsacrine-resistant human leukemia cell line with mutant topoisomerase IIalpha. dans Cancer research 1998 (PubMed)
    Show all 5 Pubmed References

  3. Human Polyclonal TOP2B Primary Antibody pour ICC, IF - ABIN251526 : Elliott, Crawford, Mulligan, Summerfield, Newton, Wallis, Mainou-Fowler, Evans, Bedwell, Durkacz, Willmore: Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia. dans British journal of haematology 2010 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal TOP2B Primary Antibody pour IHC (p), IHC - ABIN257919 : Barajon, Serrao, Arnaboldi, Opizzi, Ripamonti, Balsari, Rumio: Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia. dans The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009 (PubMed)

  5. Human Polyclonal TOP2B Primary Antibody pour ICC, IF - ABIN4361378 : Aviner, Shenoy, Elroy-Stein, Geiger: Uncovering Hidden Layers of Cell Cycle Regulation through Integrative Multi-omic Analysis. dans PLoS genetics 2015 (PubMed)

Plus d’anticorps contre Topoisomerase (DNA) II beta 180kDa partenaires d’interaction

Mouse (Murine) Topoisomerase (DNA) II beta 180kDa (TOP2B) interaction partners

  1. We demonstrated that Nup98 (Montrer NUP98 Anticorps)-TopIIbeta and Nup98 (Montrer NUP98 Anticorps)-SETBP1 (Montrer SETBP1 Anticorps) negatively regulate the XPO1 (Montrer XPO1 Anticorps)-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98 (Montrer NUP98 Anticorps)-fusion proteins induce tumorigenesis.

  2. TOP2beta as a factor involved in regulating granulosa cell genomic integrity and follicle atresia.

  3. Results identified topoisomerase IIbeta (Top2beta) as a novel determinant for camptothecin sensitivity.

  4. Top IIbeta might be a down-stream target of Nurr1 (Montrer NR4A2 Anticorps), which might influence the processes of axon genesis in dopaminergic neurons via the regulation of TOP IIbeta expression.

  5. Findings suggest a chromatin-based targeting of Top2beta to regulatory regions in the genome to govern the transcriptional program associated with neuronal differentiation and longevity.

  6. Data suggest that activity of TOP2B in elongating spermatids is strongly inhibited by PARP1 (Montrer PARP1 Anticorps) and PARP2 (Montrer PARP2 Anticorps), and this is in turn counteracted by the PAR (Montrer AFG3L2 Anticorps)-degrading activity of PAR (Montrer AFG3L2 Anticorps) glycohydrolase.

  7. proteasomal degradation of TOP2beta induced by the TOP2-DNA covalent complex or the TOP2 circular clamp is due to transcriptional arrest but not DNA damage

  8. DNA topoisomerase II beta deficiency severely affects cerebral cortex stratification: no subplate is discernible, and neurons born at later stages of corticogenesis fail to migrate to the superficial layers.

  9. A nuclear matrix-associated (Montrer SMARCA5 Anticorps) topoisomerase IIB (TOP2B) interacting with an extracellular Mn2+/Ca2 (Montrer CA2 Anticorps)+-dependent nuclease (Montrer DCLRE1C Anticorps) cleaves sperm DNA into loop-sized fragments.

  10. These results suggest that the defect in establishing neuromuscular junctions in top2beta knockout mice could be due to the lack of TopIIbeta-mediated neurite outgrowth.

Human Topoisomerase (DNA) II beta 180kDa (TOP2B) interaction partners

  1. The article discusses origin of topoisomerase II beta, its structure, activities reported in vitro and in vivo along with implications in cellular processes namely transcription, DNA repair, neuronal development, aging, HIV-infection and cancer. (Review)

  2. recent data point to a critical role of topoisomerase II beta (TOP2B), which is a primary target of anthracycline poisoning, in the pathophysiology of anthracycline-induced congestive heart failure .

  3. The decatenation checkpoint is regulated, not only by topo IIalpha, as previously reported, but also by topo IIbeta. The decatenation checkpoint is most efficient when both isoforms are present. Deletion of most of the C-terminus of topo IIbeta, while preserving the nuclear localization signal, and mutation of Y656 in topo IIbeta inhibits the decatenation checkpoint and sensitivity to topo II (Montrer TOP2 Anticorps)-targeted drugs.

  4. TOP2B is positioned to solve topological problems at diverse cis-regulatory elements and its occupancy is a highly ordered and prevalent feature of CTCF/cohesin binding sites that flank TADs.

  5. Data indicate that cortex involvement, lower World Health Organization grade and DNA topoisomerase II (Montrer TOP2 Anticorps) positivity were strong predictors for preoperative epileptic seizures.

  6. during early development, TOP2A (Montrer TOP2A Anticorps) is likely to have a role in cell proliferation, whereas TOP2B is expressed in post-mitotic cells and may be important in controlling expression of long genes even at this early stage.

  7. Cinobufacini inhibited the proliferation of the HepG-2 cells induced apoptosis in a dose- and time-dependent manner and downregulated the mRNA and protein expression levels of TOPO I (Montrer TOP1 Anticorps) and TOPO II (Montrer TOP2 Anticorps)

  8. A direct interaction between Ku70 (Montrer XRCC6 Anticorps)/86 and BRG1 (Montrer SMARCA4 Anticorps) brings together SWI (Montrer SMARCA1 Anticorps)/SNF (Montrer SNRPA Anticorps) remodeling capabilities and TOP2beta activity to enhance the transcriptional response to hormone stimulation.

  9. Human cytomegalovirus IE1 exon 4 interacts with Topoisomerase IIbeta (TOPOIIbeta), whose activity is required for viral genome persistence and maintenance via binding to a cis (Montrer CISH Anticorps)-acting viral maintenance element.

  10. Proteolytic degradation of Top2 (Montrer TOP2A Anticorps) enables the processing of Top2 (Montrer TOP2A Anticorps).DNA and Top2 (Montrer TOP2A Anticorps).RNA covalent complexes by TDP2 (Montrer TDP2 Anticorps).

Topoisomerase (DNA) II beta 180kDa (TOP2B) profil antigène

Profil protéine

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants\; however, the second variant has not yet been fully described.

Gene names and symbols associated with TOP2B

  • DNA topoisomerase II beta (TOP2B) anticorps
  • topoisomerase (DNA) II beta (Top2b) anticorps
  • DNA topoisomerase II beta (Top2b) anticorps
  • microRNA 4442 (MIR4442) anticorps
  • D230016L12Rik anticorps
  • Top-2 anticorps
  • TOP2B anticorps
  • top2beta anticorps
  • TOPIIB anticorps

Protein level used designations for TOP2B

topoisomerase (DNA) II beta 180kDa , DNA topoisomerase II, beta isozyme , DNA topoisomerase 2-beta , topoisomerase II beta , DNA topoisomerase II beta , DNA topoisomerase II, 180 kD , U937 associated antigen , antigen MLAA-44 , topo II beta , topoisomerase IIb , DNA topoisomeraseII_beta , topoisomerase II beta-2

460232 Pan troglodytes
21974 Mus musculus
361100 Rattus norvegicus
7155 Homo sapiens
395966 Gallus gallus
Fournisseurs de qualité sélectionnés pour anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) Anticorps
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