Topoisomerase (DNA) II beta 180kDa Protéines (TOP2B)

TOP2B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. De plus, nous expédions Topoisomerase (DNA) II beta 180kDa Anticorps (67) et Topoisomerase (DNA) II beta 180kDa Kits (15) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
TOP2B 21974 Q64511
Rat TOP2B TOP2B 361100  
TOP2B 7155 Q02880
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Top Topoisomerase (DNA) II beta 180kDa Protéines sur

Showing 5 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
Escherichia coli (E. coli) Souris His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
Escherichia coli (E. coli) Humain Inconjugué   100 μg Connectez-vous pour afficher 11 to 18 Days

TOP2B Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) ,
Human , ,

Plus protéines pour Topoisomerase (DNA) II beta 180kDa (TOP2B) partenaires d'interaction

Mouse (Murine) Topoisomerase (DNA) II beta 180kDa (TOP2B) interaction partners

  1. Top2beta controls spinal motor neurons (MN) migration and connectivity; is not required for MN generation or survival; has a selective role in columnar specification. In absence of Top2beta, phrenic MN identity is eroded, while other motor columns are partially preserved but fail to cluster to their proper position. In Top2beta-/- mice, peripheral connectivity is impaired as MNs exhibit a profound deficit in terminal b...

  2. our data establish a combinatorial cell-autonomous and non-cell-autonomous role for Top2b in the late stage of photoreceptor differentiation and maturation

  3. We demonstrated that Nup98-TopIIbeta and Nup98-SETBP1 negatively regulate the XPO1-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98-fusion proteins induce tumorigenesis.

  4. TOP2beta as a factor involved in regulating granulosa cell genomic integrity and follicle atresia.

  5. Results identified topoisomerase IIbeta (Top2beta) as a novel determinant for camptothecin sensitivity.

  6. Top IIbeta might be a down-stream target of Nurr1, which might influence the processes of axon genesis in dopaminergic neurons via the regulation of TOP IIbeta expression.

  7. Findings suggest a chromatin-based targeting of Top2beta to regulatory regions in the genome to govern the transcriptional program associated with neuronal differentiation and longevity.

  8. Data suggest that activity of TOP2B in elongating spermatids is strongly inhibited by PARP1 and PARP2, and this is in turn counteracted by the PAR-degrading activity of PAR glycohydrolase.

  9. proteasomal degradation of TOP2beta induced by the TOP2-DNA covalent complex or the TOP2 circular clamp is due to transcriptional arrest but not DNA damage

  10. DNA topoisomerase II beta deficiency severely affects cerebral cortex stratification: no subplate is discernible, and neurons born at later stages of corticogenesis fail to migrate to the superficial layers.

  11. A nuclear matrix-associated topoisomerase IIB (TOP2B) interacting with an extracellular Mn2+/Ca2+-dependent nuclease cleaves sperm DNA into loop-sized fragments.

  12. Results support a role of topoisomerase IIbeta in activation/repression of developmentally regulated genes at late stages of neuronal differentiation.

  13. These results suggest that the defect in establishing neuromuscular junctions in top2beta knockout mice could be due to the lack of TopIIbeta-mediated neurite outgrowth.

  14. VP-16-induced carcinogenesis involves mainly the beta rather than the alpha isozyme of Top2; VP-16-induced DNA sequence rearrangements and double-strand breaks are found to be Top2beta-dependent

  15. NRF-1 can also directly interact with poly(ADP-ribose) polymerase 1 (PARP-1) and co-purify the PARP-1.DNA-PK.Ku80.Ku70.topoisomerase IIbeta-containing protein complex.

Human Topoisomerase (DNA) II beta 180kDa (TOP2B) interaction partners

  1. our data primarily indicate that topoIIbeta can be used to estimate neuronal differentiation in medulloblastoma

  2. The article discusses origin of topoisomerase II beta, its structure, activities reported in vitro and in vivo along with implications in cellular processes namely transcription, DNA repair, neuronal development, aging, HIV-infection and cancer. (Review)

  3. recent data point to a critical role of topoisomerase II beta (TOP2B), which is a primary target of anthracycline poisoning, in the pathophysiology of anthracycline-induced congestive heart failure .

  4. The decatenation checkpoint is regulated, not only by topo IIalpha, as previously reported, but also by topo IIbeta. The decatenation checkpoint is most efficient when both isoforms are present. Deletion of most of the C-terminus of topo IIbeta, while preserving the nuclear localization signal, and mutation of Y656 in topo IIbeta inhibits the decatenation checkpoint and sensitivity to topo II-targeted drugs.

  5. These results explain why hTOPIIa and hTOPIIa are differentially affected by various poisons and demonstrate the utility of C. elegans in understanding the genetics of drug responses.

  6. TOP2B is positioned to solve topological problems at diverse cis-regulatory elements and its occupancy is a highly ordered and prevalent feature of CTCF/cohesin binding sites that flank TADs.

  7. Data indicate that cortex involvement, lower World Health Organization grade and DNA topoisomerase II positivity were strong predictors for preoperative epileptic seizures.

  8. during early development, TOP2A is likely to have a role in cell proliferation, whereas TOP2B is expressed in post-mitotic cells and may be important in controlling expression of long genes even at this early stage.

  9. TopoIIbeta is involved in the cascade of coactivator complexes that are recruited to LTR for regulation of HIV-1 transcription.

  10. Cinobufacini inhibited the proliferation of the HepG-2 cells induced apoptosis in a dose- and time-dependent manner and downregulated the mRNA and protein expression levels of TOPO I and TOPO II

  11. A direct interaction between Ku70/86 and BRG1 brings together SWI/SNF remodeling capabilities and TOP2beta activity to enhance the transcriptional response to hormone stimulation.

  12. Human cytomegalovirus IE1 exon 4 interacts with Topoisomerase IIbeta (TOPOIIbeta), whose activity is required for viral genome persistence and maintenance via binding to a cis-acting viral maintenance element.

  13. This study demonstrated that top IIbeta overexpression is necessary for RA-induced neuronal differentiation.

  14. Data suggest that DNA topoisomerase IIbeta (topoIIbeta) silencing can significantly alter the gene expression pattern of genes involved in variety of biological processes and signal transduction pathways.

  15. Proteolytic degradation of Top2 enables the processing of Top2.DNA and Top2.RNA covalent complexes by TDP2.

  16. There is an association between chemosensitivity and Pgp, GST-pi and Topo II expression in gastric cancer.

  17. These results are consistent with the hypothesis that etoposide quinone contributes to etoposide-related leukemogenesis through an interaction with topoisomerase IIbeta.

  18. Downregulating topoisomerase IIbeta confers resistance specifically to mitoxantrone.

  19. Top2beta-DNA cleavage complexes arrest transcription elongation and induce a proteasomal degradation of Top2beta on DNA.

  20. results suggest that the low expression of TOPOIIbeta in patients with tongue carcinoma indicates that intrinsic drug resistance may exist in tongue carcinoma, and is associated with tumor differentiation and cisplatin resistance in tongue carcinoma.

Profil protéine Topoisomerase (DNA) II beta 180kDa (TOP2B)

Profil protéine

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants\; however, the second variant has not yet been fully described.

Gene names and symbols associated with TOP2B

  • DNA topoisomerase II beta (TOP2B)
  • topoisomerase (DNA) II beta (Top2b)
  • DNA topoisomerase II beta (Top2b)
  • microRNA 4442 (MIR4442)
  • D230016L12Rik Protéine
  • Top-2 Protéine
  • TOP2B Protéine
  • top2beta Protéine
  • TOPIIB Protéine

Protein level used designations for TOP2B

topoisomerase (DNA) II beta 180kDa , DNA topoisomerase II, beta isozyme , DNA topoisomerase 2-beta , topoisomerase II beta , DNA topoisomerase II beta , DNA topoisomerase II, 180 kD , U937 associated antigen , antigen MLAA-44 , topo II beta , topoisomerase IIb , DNA topoisomeraseII_beta , topoisomerase II beta-2

460232 Pan troglodytes
21974 Mus musculus
361100 Rattus norvegicus
7155 Homo sapiens
395966 Gallus gallus
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