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TOP3B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. De plus, nous expédions TOP3B Anticorps (50) et beaucoup plus de produits pour cette protéine.
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Results identified TOP3B gene deletion as candidate gene in the etiology of neurodevelopmental disorders including juvenile myoclonic epilepsy.
Top3b proteins from several animals associate with polyribosomes, which are units of mRNA translation, whereas the Top3 homologs from E. coli and yeast lack the association. The Top3b-polyribosome association requires TDRD3 (Montrer TDRD3 Protéines), which directly interacts with Top3beta and is present in animals but not bacteria or yeast.
TOP3B promotes transcription, protects against DNA damage, and reduces the frequency of chromosomal translocations.
the positive regulatory region including the 5'GGAACC3' core element is essential for efficient expression of the DNA topoisomerase III beta gene
DNA topoisomerase III beta has a role in infertility and aneuploidy
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity\; however, not all variants have been fully described.
DNA topoisomerase 3-beta-1
, DNA topoisomerase III beta-1
, topoisomerase III beta
, Topo III beta
, topoisomerase (DNA) III beta
, DNA topoisomerase III beta L homeolog
, topoisomerase (DNA) III beta L homeolog
, LOW QUALITY PROTEIN: DNA topoisomerase 3-beta-1