anti-Tousled-Like Kinase 1 (TLK1) Anticorps

The protein encoded by TLK1 is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. De plus, nous expédions Tousled-Like Kinase 1 Protéines (7) et Tousled-Like Kinase 1 Kits (1) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TLK1 9874 Q9UKI8
TLK1 228012 Q8C0V0
TLK1 311118  
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Top anti-Tousled-Like Kinase 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 133 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-TLK1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate 100 μL 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-TLK1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: ACHN cell lysate 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué IF, ELISA Immunofluorescence analysis of COS7 cells, using TLK1 (Ab-764) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué WB Western blot analysis of TLK1 expression in HeLa (A), NIH3T3 (B), PC12 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué WB Western blot analysis of TLK1 expression in HeLa (A), A431 (B), NIH3T3 (C), rat thymus (D) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué WB Western blot analysis of TLK1 (pS743) expression in MCF7 (A), rat brain (B), H9C2 (C) whole cell lysates. 200 μL 13 to 14 Days
$575.00
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué ICC, IF, WB ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using TLK1, antibody at 1:200 dilution. WB Image Sample(30 μg of whole cell lysate) A:293T 7.5% SDS PAGE antibody diluted at 1:500 100 μL 3 to 4 Days
$466.18
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL Disponible
$363.46
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of hela cells, using Phospho-TLK1 (Ser743) Antibody. ABIN6267198 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Détails

anti-Tousled-Like Kinase 1 Anticorps mieux référencés

  1. Human Polyclonal TLK1 Primary Antibody pour IHC (p), ELISA - ABIN544276 : Krause, Jonnalagadda, Gatei, Sillje, Zhou, Nigg, Khanna: Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. dans Oncogene 2003 (PubMed)
    Show all 3 Pubmed References

  2. Cow (Bovine) Polyclonal TLK1 Primary Antibody pour WB - ABIN2787642 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... dans Molecular systems biology 2007 (PubMed)

Plus d’anticorps contre Tousled-Like Kinase 1 partenaires d’interaction

Human Tousled-Like Kinase 1 (TLK1) interaction partners

  1. Overexpression of TLK1 substantially reduces DNA damage and G2/M arrest by activation of TLK1-dependent cell cycle checkpoint response.

  2. Following DNA damage, addition of the TLK1 inhibitor, THD, or overexpression of NEK1-T141A mutant impaired ATR and Chk1 activation, indicating the existence of a TLK1>NEK1>ATR>Chk1 pathway. Indeed, overexpression of the NEK1-T141A mutant resulted in an altered cell cycle response after exposure of cells to oxidative stress, including bypass of G1 arrest and implementation of an intra S-phase checkpoint.

  3. Our results suggest that GA-mediated transient modulation of TLK1 activity promotes DNA repair and suppresses radiation cytoxicity in salivary gland cells.

  4. TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint

  5. Data indicate Tousled-like kinases (TLK1) phosphorylation has an impact on cell cycle proteins Asf1a and Asf1b function.

  6. Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit.

  7. TLKs appear to be intimately linked to the pattern of resistance to DNA damage, and specifically double-strand breaks.

  8. Adenoviral delivery of Tousled kinase protects salivary glands against ionizing radiation damage.

  9. Silencing of TLK1 enhanced DNA damage induced by cisplatin treatment, suggesting that TLK1 plays a pivotal role for the repair of cisplatin-induced DNA damage.

  10. ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases.

  11. we show that Chk1 is essential for the suppression of TLK activity after replication block, but that ATR, Chk2 and BRCA1 are dispensable for TLK suppression.

  12. Both eIF4E and TLK1B are elevated in breast cancer specimens but not in benign breast specimens from noncancer patients. Degree of TLK1B elevation is correlated with degree of IF4E overexpression.

  13. In addition, it could be demonstrated that increasing the Tlk1 activity in HT1080 cells by forced Tlk1 overexpression leads to an increased phosphorylation of endogenous p68.

  14. TLK1B promotes the repair of double strand breaks, likely as a consequence of a change in chromatin remodeling capacity that must precede the assembly of repair complexes at the sites of damage

  15. Studies provide evidence for TLK1B-mediated phosphorylation of Asf1 triggering DNA repair.

  16. Our data suggest that human PKU-beta/TLK1 plays an important role in chromosome integrity via the regulation of myosin II dynamics by phosphorylating MRLC during mitosis.

Mouse (Murine) Tousled-Like Kinase 1 (TLK1) interaction partners

  1. our data suggest that Tlk1 negatively regulates the expression of pluripotency factors, thereby contributing to the scheduled differentiation of mouse ESCs.

  2. TLK1 and TLK2 have largely redundant roles in genome maintenance.

  3. present direct evidence that TLK1B can promote repair of linearized plasmids with incompatible ends that require processing prior to ligation.

Caenorhabditis elegans (C. elegans) Tousled-Like Kinase 1 (TLK1) interaction partners

  1. TLK-1 contributes to chromosome condensation and segregation;TLK-1 functions in cytokinesis by localizing AIR-2 to the midzone microtubules.

  2. Tousled-like kinase (TLK-1) contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase AIR-2.

Tousled-Like Kinase 1 (TLK1) profil antigène

Profil protéine

The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TLK1

  • tousled like kinase 1 (TLK1) anticorps
  • tousled-like kinase 1 (Tlk1) anticorps
  • tousled-like kinase 1b (tlk1b) anticorps
  • tousled like kinase 1 like (TLK1L) anticorps
  • tousled-like kinase 1 (TLK1) anticorps
  • serine/threonine-protein kinase TOUSLED (LOC542181) anticorps
  • tousled-like kinase 1a (tlk1a) anticorps
  • tousled like kinase 1 (tlk1) anticorps
  • Serine/threonine-protein kinase tousled-like 1 (tlk-1) anticorps
  • tousled like kinase 1 (Tlk1) anticorps
  • 4930545J15Rik anticorps
  • DKFZp459L163 anticorps
  • fb76h12 anticorps
  • fe11e12 anticorps
  • PKU-beta anticorps
  • si:dkey-88m1.1 anticorps
  • si:dkey-251e16.4 anticorps
  • TLK1 anticorps
  • wu:fb76h12 anticorps
  • wu:fe11e12 anticorps

Protein level used designations for TLK1

SNARE protein kinase SNAK , serine threonine protein kinase , serine/threonine-protein kinase tousled-like 1 , pKU-beta protein kinase , serine/threonine-protein kinase tousled-like 1-B , tousled-like kinase 1 , tousled-like kinase 1-B , LOW QUALITY PROTEIN: serine/threonine-protein kinase tousled-like 1

GENE ID SPECIES
9874 Homo sapiens
228012 Mus musculus
311118 Rattus norvegicus
326734 Danio rerio
429024 Gallus gallus
459729 Pan troglodytes
478795 Canis lupus familiaris
537517 Bos taurus
542181 Zea mays
557765 Danio rerio
100024843 Monodelphis domestica
100052963 Equus caballus
100144941 Xenopus (Silurana) tropicalis
100157412 Sus scrofa
100174001 Pongo abelii
100345497 Oryctolagus cuniculus
100554902 Anolis carolinensis
100591136 Nomascus leucogenys
176369 Caenorhabditis elegans
100734588 Cavia porcellus
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