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TFCP2 encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene.
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TFCP2 acts as a transcription co-factor that stimulates YAP (Montrer YAP1 Anticorps) transcription by facilitating YAP (Montrer YAP1 Anticorps) binding with YAP (Montrer YAP1 Anticorps) binding motif (YBF)-containing transcription factors.
High expression of CP2c was significantly correlated with patient age, and higher histological grade, stage, and small and large vessel invasion in HCC (Montrer FAM126A Anticorps) tissues.
FQI1 mediates alteration of the tumor epigenome by DNMT1 (Montrer DNMT1 Anticorps)-LSF complex disruption, leading to aberrant DNA methylation (Montrer HELLS Anticorps) and gene expression.
The results suggest potential roles of LSF (TFCP2 ) as a growth regulator through control of the transcription of p21CIP1 (Montrer CDKN1A Anticorps) in melanocytes and melanoma cells as well as a biomarker for nevus.
Complement proteins C7 and CFH (Montrer CFH Anticorps) control the stemness of liver cancer cells via LSF-1 pathway.
LSF is an important mediator in colorectal carcinoma tumorigenesis and progression, and LSF expression is an important index for and prognostic prediction.
Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene (Montrer RAB1A Anticorps) addiction to LSF in hepatocellular carcinoma
Secreted OPN (Montrer SPP1 Anticorps), induced by LSF, activates c-Met via a potential interaction between OPN (Montrer SPP1 Anticorps) and its cell surface receptor CD44 (Montrer CD44 Anticorps). A significant correlation was observed among LSF, OPN (Montrer SPP1 Anticorps), and activated c-Met levels in HCC (Montrer FAM126A Anticorps).
Inhibition of MMP-9 (Montrer MMP9 Anticorps) significantly abrogated LSF-induced angiogenesis as well as in vivo tumorigenesis, thus reinforcing the role of MMP-9 (Montrer MMP9 Anticorps) in facilitating LSF function.
Data suggest that LSF is a key mediator of the Notch1 (Montrer NOTCH1 Anticorps) signaling pathway, suggesting that it might be a novel therapeutic target for the treatment of hepatocellular carcinoma.
The transcription factor CP2 upregulated miR (Montrer MLXIP Anticorps)-144 expression, which partially contributed to the suppression of COX-2 (Montrer COX2 Anticorps) in mGCs.
that yin yang 1 (Montrer YY1 Anticorps) strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis
present study shows that a transcription factor previously unrelated with epithelial-mesenchymal transition (EMT (Montrer ITK Anticorps)), TFCP2c/LSF/LBP-1c, was translocated to the nucleus and bound to the fibronectin (Montrer FN1 Anticorps) promoter upon EMT (Montrer ITK Anticorps) induction by Snail1 (Montrer SNAI1 Anticorps)
the binding of Pin1 (Montrer PIN1 Anticorps) at the Thr (Montrer TRH Anticorps)-329-Pro-330 motif in LSF permits isomerization by Pin1 (Montrer PIN1 Anticorps) of the peptide bonds at the nearby phosphorylated SP motifs (Ser (Montrer SIGLEC1 Anticorps)-291 and Ser (Montrer SIGLEC1 Anticorps)-309) to the trans configuration, thereby facilitating their dephosphorylation.
CP2 contributes to the pathogenesis of Alzheimer's disease by inducing transferrin (Montrer Tf Anticorps) expression via up-regulating its transcription.
CP2 is a major factor in the regulation of globin expression in human and mouse erythroid cells, and CP2 binding to the globin gene promoter is essential for the enhanced transcription of globin genes in erythroid differentiation.
CP2 plays important role during bone development by activating BMP4 (Montrer BMP4 Anticorps) transcription
A novel murine splice isoform of CP2, CP2b (Montrer CYP27B1 Anticorps), which is identical to CP2a except that it has an additional 36 amino acids encoded by an extra exon was identified and characterized.
findings demonstrate that the APLP2-intracellular C-terminal domains interact with CP2 transcription factor in the nucleus and induce the expression of glycogen synthase kinase 3beta
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease.
transcription factor CP2
, cCP2 transcription factor
, SAA3 enhancer factor
, alpha-globin transcription factor CP2