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TFEC encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors.
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Human Polyclonal TFEC Primary Antibody pour WB - ABIN1881878
Chung, Kim, Kawamoto: TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells. dans Biochemistry 2001
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Human Polyclonal TFEC Primary Antibody pour ELISA, WB - ABIN249519
Yasumoto, Shibahara: Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator. dans Biochimica et biophysica acta 1997
The zebrafish genome contain two mitf (mitfa (Montrer MITF Anticorps) and mitfb (Montrer MITF Anticorps)), two tfe3 (Montrer TFE3 Anticorps) (tfe3a and tfe3b), and single tfeb (Montrer TFEB Anticorps) and tfec genes.
Data show that expression of Mitf (Montrer MITF Anticorps) rescues pigmentation fully in zebrafish, but only partially in Sox10 (Montrer SOX10 Anticorps)-mutant mice.
Two alternatively spliced TFEC isoforms have been found to be sequence-specific transcriptional activators of the nonmuscle myosin II heavy chain-A (Montrer MYH9 Anticorps) gene in transfected cells.
Tfec transcribes IL-4 receptor alpha (Montrer IL4R Anticorps) expression to promote M2 programming in macrophages
Data indicate that FOS, SPI1 (Montrer SPI1 Anticorps), KLF10 (Montrer KLF10 Anticorps), TFEC, and PRDM16 (Montrer PRDM16 Anticorps) show robust transcriptional cross-regulation and are often associated with osteoclastogenesis.
Transcription factor EC, along with several other transcription factors, is a Stat6 (Montrer STAT6 Anticorps)-dependent target of IL-4 (Montrer IL4 Anticorps).
This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
transcription factor EC
, class E basic helix-loop-helix protein 34