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The protein encoded by TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. De plus, nous expédions TM4SF1 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal TM4SF1 Primary Antibody pour IHC (p), WB - ABIN656640
Wang, Bao, Zhang, Cui, Shi: Transmembrane-4-L-six-family-1, a potential predictor for poor prognosis, overexpressed in human glioma. dans Neuroreport 2015
TM4SF1 was recognized as a direct target for miR (Montrer MLXIP Anticorps)-520f in hepatocellular carcinoma (HCC (Montrer FAM126A Anticorps)) cells where its expression was found up-regulated and inversely correlated with that of mir (Montrer MLXIP Anticorps)-520f.
Results suggest that miR (Montrer MLXIP Anticorps)-30a is an important regulator of TM4SF1, VEGF (Montrer VEGFA Anticorps), and E-cadherin (Montrer CDH1 Anticorps) for CRC (Montrer CALR Anticorps) lymph node metastasis, a potential new therapeutic target in CRC (Montrer CALR Anticorps).
High TM4SF1 expression is associated with esophageal cancer.
Replacement of the transmembrane 4 L six family protein TM4SF1 or TM4SF4 (Montrer TM4SF4 Anticorps) C-terminus with that of TM4SF5 (Montrer TM4SF5 Anticorps) increased spheroids growth, transwell migration, and invasive dissemination from spheroids in 3D collagen gels.
Results indicate that the expression of transmembrane 4 L6 family member 1 (TM4SF1) is higher in pancreatic cancer tissues and pancreatic cancer cell lines than controls.
Results show that TM4SF1 expression is elevated in colorectal cancer (CRC (Montrer CALR Anticorps)), and associated with tumor stage and lymph node metastasis. Also, miR (Montrer MLXIP Anticorps)-9 directly targeted its binding site in the TM4SF1 3'-UTR (Montrer UTS2R Anticorps), which has a critical role in regulating CRC (Montrer CALR Anticorps) cell migration. and invasion. Furthermore, miR (Montrer MLXIP Anticorps)-9 regulated cell motility via suppressing
The findings suggest that TM4SF1 is a surface membrane antigen that is highly expressed in pancreatic cancer cells and increases the chemoresistance to gemcitabine. TM4SF1 may be a promising target to overcome the chemoresistance of pancreatic cancer.
TM4SF1 overexpression significantly contributed MDA-MB-231 cell migration but decreased apoptotic cells
Study shows that TM4SF1 expression is associated with better prognosis in pancreatic cancer. Its loss contributes to the invasion and migration of pancreatic cancer cells.
We found that miR (Montrer MLXIP Anticorps)-203 was significantly downregulated in OSF (Montrer OSTF1 Anticorps) tissues compared to that in normal buccal mucosa tissues, and that miR (Montrer MLXIP Anticorps)-203 negatively regulated secreted SFRP4 (Montrer SFRP4 Anticorps) and positively regulated TM4SF1
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.
transmembrane 4 L six family member 1
, transmembrane 4 superfamily member 1
, transmembrane 4 L6 family member 1
, membrane component chromosome 3 surface marker 1
, membrane component, chromosome 3, surface marker 1
, tumor-associated antigen L6
, Tumor-associated antigen L6 homolog
, 12A8 target antigen
, L6 antigen
, membrane component chromosome 3 surface marker 1 homolog
, membrane component, surface marker 1