Transmembrane 4 L Six Family Member 1 Protéines (TM4SF1)

The protein encoded by TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. De plus, nous expédions TM4SF1 Anticorps (70) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
TM4SF1 4071 P30408
Rat TM4SF1 TM4SF1 295061  
TM4SF1 17112 Q64302
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Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,493.38
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails

TM4SF1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Transmembrane 4 L Six Family Member 1 (TM4SF1) partenaires d'interaction

Human Transmembrane 4 L Six Family Member 1 (TM4SF1) interaction partners

  1. our study provides a novel regulatory pathway involving TM4SF1, DDR1, MMP2 and MMP9, which promotes the formation and function of invadopodia to support cell migration and invasion in pancreatic cancer.

  2. Regulation of transmembrane-4-L-six-family-1 (TM4SF1) on bladder cancer cell could be induced by peroxisome proliferator-activated receptor gamma (PPARgamma)-sirtuin 1 (SIRT1) feedback loop.

  3. TM4SF1 was recognized as a direct target for miR-520f in hepatocellular carcinoma (HCC) cells where its expression was found up-regulated and inversely correlated with that of mir-520f.

  4. Results suggest that miR-30a is an important regulator of TM4SF1, VEGF, and E-cadherin for CRC lymph node metastasis, a potential new therapeutic target in CRC.

  5. High TM4SF1 expression is associated with esophageal cancer.

  6. Replacement of the transmembrane 4 L six family protein TM4SF1 or TM4SF4 C-terminus with that of TM4SF5 increased spheroids growth, transwell migration, and invasive dissemination from spheroids in 3D collagen gels.

  7. Results indicate that the expression of transmembrane 4 L6 family member 1 (TM4SF1) is higher in pancreatic cancer tissues and pancreatic cancer cell lines than controls.

  8. Results show that TM4SF1 expression is elevated in colorectal cancer (CRC), and associated with tumor stage and lymph node metastasis. Also, miR-9 directly targeted its binding site in the TM4SF1 3'-UTR, which has a critical role in regulating CRC cell migration. and invasion. Furthermore, miR-9 regulated cell motility via suppressing

  9. The findings suggest that TM4SF1 is a surface membrane antigen that is highly expressed in pancreatic cancer cells and increases the chemoresistance to gemcitabine. TM4SF1 may be a promising target to overcome the chemoresistance of pancreatic cancer.

  10. TM4SF1 overexpression significantly contributed MDA-MB-231 cell migration but decreased apoptotic cells

  11. Study shows that TM4SF1 expression is associated with better prognosis in pancreatic cancer. Its loss contributes to the invasion and migration of pancreatic cancer cells.

  12. We found that miR-203 was significantly downregulated in OSF tissues compared to that in normal buccal mucosa tissues, and that miR-203 negatively regulated secreted SFRP4 and positively regulated TM4SF1

  13. Transmembrane-4-L-six-family-1 is overexpressed in human gliomas in general and the precise level of expression might predict outcome and could be of clinical value.

  14. These findings validate TM4SF1 as an attractive candidate for cancer therapy with antibody-bound toxins that have the capacity to react with either cytoplasmic or nuclear targets in tumor cells or tumor-associated vascular endothelium.

  15. TM4SF1 is a small plasma membrane glycoprotein that regulates cell motility and proliferation, and possibly a new vascular therapeutic target in cancer

  16. High TM4SF1 expression is associated with pancreatic cancer.

  17. TM4SF1, like genuine tetraspanins, serves as a molecular organizer that interacts with membrane and cytoskeleton-associated proteins and uniquely initiates the formation of nanopodia and facilitates cell polarization and migration.

  18. We provide evidence that ARHGDIA, COBLL1, and TM4SF1 are negative regulators of apoptosis in cultured tumor cells.

  19. Inhibition of cell migration after targeted knockdown of TM4SF1 protein expression suggests its contribution to prostate cancer cell metastasis.

  20. TM4SF1 can serve as a surface protein marker which singly identifies MSCs from diverse cell sources, in particular, fibroblast-rich connective tissues

Mouse (Murine) Transmembrane 4 L Six Family Member 1 (TM4SF1) interaction partners

  1. TAL6 may play a role in cancer invasion and metastasis

Profil protéine TM4SF1

Profil protéine

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.

Gene names and symbols associated with TM4SF1

  • transmembrane 4 L six family member 1 (TM4SF1)
  • transmembrane 4 L six family member 1 S homeolog (tm4sf1.S)
  • transmembrane 4 L six family member 1 (tm4sf1)
  • transmembrane 4 L six family member 1 (Tm4sf1)
  • transmembrane 4 superfamily member 1 (Tm4sf1)
  • H-L6 Protéine
  • L6 Protéine
  • M3s1 Protéine
  • MGC85546 Protéine
  • MM3 Protéine
  • TAAL6 Protéine

Protein level used designations for TM4SF1

transmembrane 4 L six family member 1 , transmembrane 4 superfamily member 1 , transmembrane 4 L6 family member 1 , membrane component chromosome 3 surface marker 1 , membrane component, chromosome 3, surface marker 1 , tumor-associated antigen L6 , Tumor-associated antigen L6 homolog , 12A8 target antigen , L6 antigen , membrane component chromosome 3 surface marker 1 homolog , membrane component, surface marker 1

GENE ID SPECIES
425046 Gallus gallus
447175 Xenopus laevis
460770 Pan troglodytes
485710 Canis lupus familiaris
533038 Bos taurus
100151707 Xenopus (Silurana) tropicalis
4071 Homo sapiens
295061 Rattus norvegicus
101833523 Mesocricetus auratus
100171795 Pongo abelii
17112 Mus musculus
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