Transmembrane Protein 27 Protéines (TMEM27)

TMEM27 encodes a transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules.

afficher tous les protéines Gène GeneID UniProt
Humain TMEM27 TMEM27 57393 Q9HBJ8
Souris TMEM27 TMEM27 57394 Q9ESG4
Rat TMEM27 TMEM27 57395 Q9ESG3
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Showing 10 out of 17 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$4,649.05
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$4,744.22
Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$4,744.22
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$6,616.87
Détails
Human Cells Humain Fc Tag 100 μg Connectez-vous pour afficher 20 to 21 Days
$382.80
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,258.67
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,258.67
Détails
Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$496.00
Détails

Plus protéines pour Transmembrane Protein 27 (TMEM27) partenaires d'interaction

Human Transmembrane Protein 27 (TMEM27) interaction partners

  1. Lack of expression of the TMEM27 in conventional renal cell carcinoma (Montrer MOK Protéines) defines a group of patients at high risk for cancer-related death.

  2. Tmem27 is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals.

  3. Bace2 (Montrer BACE2 Protéines) specifically targets Tmem27 and cleaves its extracellular domain, which is then shed from the plasma membrane of pancreatic beta cells.

  4. Tmem27 dimerization is a dynamic process involving Bace2 (Montrer BACE2 Protéines)

  5. Collectrin and ACE2 (Montrer ACE2 Protéines) in renal and intestinal amino acid transport.

  6. Data support a role for TMEM27 in glucose-induced insulin (Montrer INS Protéines) secretion but not in cell proliferation. The finding that its cleavage is not specific to beta cells challenges the current support for its use as a potential beta cell mass biomarker.

  7. Collectrin has a role in amino acid transpor in the kidney [review]

  8. the first human study of the gene TMEM27 and an attempt to shine a light on genotype-phenotype correlation in Turner syndrome patients.

  9. No TMEM27 gene mutations were discovered among 26 patients showing a phenotype resembling Dent's disease

Mouse (Murine) Transmembrane Protein 27 (TMEM27) interaction partners

  1. this study shows that Tmem27-mediated cross-presentation supports intrahepatic adaptive antiviral immune responses and may lead to insights into the nature of how the liver acts as a primary site of CD8 (Montrer CD8A Protéines)+ T cell activation

  2. analysis of the interaction of amino acid transporters B0AT1 (Montrer SLC6A19 Protéines) and B0AT3 with their ancillary protein collectrin

  3. Collectrin is a consequential link between the transport of l-arginine (Montrer GATM Protéines) and endothelial nitric oxide synthase (Montrer NOS3 Protéines) uncoupling in hypertension.

  4. Collectrin and ACE2 (Montrer ACE2 Protéines) in renal and intestinal amino acid transport.

  5. transcriptional hierarchy between HNF-1beta (Montrer HNF1B Protéines) and PKD (Montrer PRKD1 Protéines) (polycystic kidney disease) genes expressed in the primary cilia of collecting duct cells has been suggested, and collectrin is one of such HNF-1beta (Montrer HNF1B Protéines) regulated genes

  6. Tmem27 is a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets

  7. Our data suggest that collectrin is a novel mediator of renal amino acid transport and may provide further insight into the pathogenesis of a number of human disease correlates.

  8. data identify collectrin as a key regulator of renal amino acid uptake

  9. Collectrin has a role in amino acid transpor in the kidney [review]

  10. functional association of mutant B(0)AT1 (Montrer SLC6A19 Protéines) transporters with ACE2 (Montrer ACE2 Protéines) and collectrin in intestine and kidney, respectively, participates in the phenotypic heterogeneity of Hartnup disorder

Profil protéine TMEM27

Profil protéine

This gene encodes a transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells.

Gene names and symbols associated with TMEM27

  • transmembrane protein 27 L homeolog (tmem27.L)
  • si:dkey-194e6.1 (si:dkey-194e6.1)
  • transmembrane protein 27 (TMEM27)
  • transmembrane protein 27 (tmem27)
  • transmembrane protein 27 (Tmem27)
  • 0610008J07Rik Protéine
  • collectrin Protéine
  • MGC68634 Protéine
  • NX-17 Protéine
  • Nx17 Protéine
  • tmem27 Protéine

Protein level used designations for TMEM27

transmembrane protein 27 , kidney-specific membrane protein , collectrin

GENE ID SPECIES
379678 Xenopus laevis
402976 Danio rerio
418622 Gallus gallus
100144643 Xenopus (Silurana) tropicalis
57393 Homo sapiens
57394 Mus musculus
57395 Rattus norvegicus
513188 Bos taurus
611445 Canis lupus familiaris
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