anti-Treacher Collins-Franceschetti Syndrome 1 (TCOF1) Anticorps

TCOF1 encodes a nucleolar protein with a LIS1 homology domain. De plus, nous expédions TCOF1 Kits (5) et TCOF1 Protéines (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TCOF1 291571  
TCOF1 21453 O08784
TCOF1 6949 Q13428
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Top anti-TCOF1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 47 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué ChIP, IC, IF, IHC, WB Immunofluorescent analysis of TCOF1 staining in HEK293T cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of TCOF1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué IHC, ELISA, WB Western blot analysis of extracts from Jurkat/293/HeLa cells, using TCOF1 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TCOF1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, IHC, WB Western blot analysis of extracts from Jurkat cells, using TCOF1 antibody. ABIN6274338 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p), WB 50 μL 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, IHC, WB Western blot analysis of Jurkat whole cell lysates, using TCOF1 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277236 staining  Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
$390.77
Détails
Humain Souris Inconjugué IF, ELISA, WB Western Blot analysis of TCOF1 expression in transfected 293T cell line by TCOF1 monoclonal antibody (M02), clone 8H3.Lane 1: TCOF1 transfected lysate(152.104 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of monoclonal antibody to TCOF1 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg 11 to 12 Days
$440.00
Détails
Humain Lapin Inconjugué IHC, WB 100 μL 11 to 13 Days
$366.77
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of extracts from Jurkat/293/HeLa cells, using TCOF1 Antibody . The lane on the right is treated with the synthesized peptide. 50 μL 11 to 13 Days
$768.40
Détails
Humain Lapin Inconjugué ELISA, IF, IHC, WB   100 μL Disponible
$363.46
Détails
Humain Lapin Inconjugué IP Immunoprecipitation of TCOF1 transfected lysate using anti-TCOF1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with TCOF1 MaxPab mouse polyclonal antibody (B01) . 100 μL 11 to 12 Days
$425.71
Détails

anti-TCOF1 Anticorps mieux référencés

  1. Human Polyclonal TCOF1 Primary Antibody pour ICC, IF - ABIN4362220 : Larsen, Hari, Clapperton, Gwerder, Gutsche, Altmeyer, Jungmichel, Toledo, Fink, Rask, Grøfte, Lukas, Nielsen, Smerdon, Lukas, Stucki: The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. dans Nature cell biology 2014 (PubMed)

  2. Human Polyclonal TCOF1 Primary Antibody pour ICC, IF - ABIN4362221 : Calo, Gu, Bowen, Aryan, Zalc, Liang, Flynn, Swigut, Chang, Attardi, Wysocka: Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. dans Nature 2018 (PubMed)

Plus d’anticorps contre TCOF1 partenaires d’interaction

Mouse (Murine) Treacher Collins-Franceschetti Syndrome 1 (TCOF1) interaction partners

  1. Role of Tcof1 in normal embryonic development, the correlation between genetic and environmental factors on the severity of craniofacial abnormalities, and the prospect for prenatal prevention of craniofacial anomalies. [review]

  2. Tcof1 acts as a modifier of Pax3 during enteric nervous system development.

  3. identified Tcof1 as an important regulator of vagal neural crest cells (NCC) development and enteric nervous system formation; Tcof1 loss-of-function results in a deficiency of vagal NCC and their delayed colonization of the gut during early embryogenesis, which mimics the early stages of Hirschsprung's disease

  4. our research has therefore identified Treacle and as novel in vivo regulators of spindle fidelity, mitotic progression, and proliferation in the maintenance and localization of neural progenitor cells.

  5. Loss-of-function mutation in Tcof1 results in defects in middle ear postnatal development and conductive hearing loss.

  6. Results show that treacle is involved in ribosomal DNA gene transcription by interacting with upstream binding factor (UBF).

  7. Data show that Tcof1 and treacle synthesis play an important role in the proliferation of neuroblastoma cells.

  8. Analysis of RNA isolated from wild-type and Tcof1+/- heterozygous mice embryos from strains that exhibit a lethal phenotype showed significant reduction in 2'-O-methylation at nucleotide C463 of 18S rRNA

  9. A minimal promoter fragment from -253 to +43 bp directs constitutive expression in both cell types, and dual regulation of Tcof1 appears to be through differential repression of this minimal promoter.

  10. It has been hypothesized that mutations in Tcof1 disrupt ribosome biogenesis to a degree that is insufficient to meet the proliferative needs of the neuroepithelium and neural crest cells.

Human Treacher Collins-Franceschetti Syndrome 1 (TCOF1) interaction partners

  1. Data indicate that Treacher Collins-Franceschetti syndrome 1 protein (TCOF1) was the main disease-causing gene for the Chinese Treacher Collins syndrome (TCS) population and its mutation spectrum.

  2. Performed mutational analysis of TCOF1, GSC, and HOXA2 to determine the mutational features of the 3 genes in Chinese patients with Treacher Collins syndrome.

  3. The analysis results showed that the Tcof1-related genes were enriched in various biological processes, including cell proliferation, apoptosis, cell cycle, differentiation, and migration.

  4. We report a clinical and extensive molecular study, including TCOF1, POLR1D, POLR1C, and EFTUD2 genes, in a series of 146 patients with TCS.

  5. Autosomal recessive POLR1D mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome.

  6. findings identify TCOF1 as a DDR factor that could cooperate with ATM and NBS1 to suppress inappropriate rDNA transcription and maintain genomic integrity after DNA damage.

  7. we describe for the first time, two patients with MFD and ID and for whom a deletion encompassing TCOF1 and CAMK2A has been identified

  8. Mutations in TCOF1, POLR1C and POLR1D have all been implicated in causing TCS

  9. Treacle-mediated NBS1 recruitment into the nucleoli regulates rRNA silencing in trans in the presence of distant chromosome breaks.

  10. TCOF1 genetic mutation can be a cause of Treacher Collins syndrome in Chinese patients.

  11. Presents the case of a male with Treacher Collins syndrome with a heterozygous de novo frameshift mutation within the TCOF1 gene (c.790_791delAG,p.Ser264GlnfsX7), as well as findings from three other individuals from two families with the same mutation.

  12. 6 of 12 patients diagnosed with hemifacial microsomia exhibited a novel frameshift mutation c. 4127 ins G in exon 24 in the TCOF1 gene.

  13. Gene rearrangements in TCOF1 are responsible for Treacher-Collins-Franceschetti syndrome.

  14. Fifteen mutations were reported, including twelve novel and three already described in 14 sporadic patients and in 3 familial cases of Treacher Collins syndrome.

  15. We demonstrated that adult leucocytes and mesenchymal cells from TCS patients present significantly reduced levels of TCOF1

  16. The identification of a novel pathogenic missense change in exon 2 of the TCOF1 gene suggests that a functionally important domain of treacle exists near the N-terminus.

  17. Patients with Goldenhar, Nager, or Miller syndromes may resemble Treacher-Collins, but are unlikely to have mutations at this locus.

  18. Identification of 231-nucleotide(nt) exon 6A and 108-nt exon 16A and isoforms with exon 6A are up to 3.7-fold more abundant than alternatively spliced variants without exon 6A, but only minor isoforms contain exon 16A.

  19. In this study we identified a TCOF1 1408delAG heterozygous mutation in a patient with the clinical diagnosis of TCS (treacher collins syndrome).

  20. Results show that treacle is involved in ribosomal DNA gene transcription by interacting with upstream binding factor (UBF).

TCOF1 profil antigène

Profil protéine

This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TCOF1

  • treacle ribosome biogenesis factor 1 (Tcof1) anticorps
  • treacle ribosome biogenesis factor 1 (TCOF1) anticorps
  • AA408847 anticorps
  • AW209012 anticorps
  • MFD1 anticorps
  • TCOF1 anticorps
  • TCS1 anticorps
  • treacle anticorps

Protein level used designations for TCOF1

Treacher Collins Franceschetti syndrome 1, homolog , Treacher Collins-Franceschetti syndrome 1 homolog , treacle protein , tcof1 gene exons 14-15-16a-16b , tcof1 gene exons 7-13 , treacle , Treacher Collins-Franceschetti syndrome 1 , treacle protein-like , treacher Collins syndrome protein homolog , Treacher Collins syndrome protein , nucleolar trafficking phosphoprotein

GENE ID SPECIES
291571 Rattus norvegicus
403592 Canis lupus familiaris
416276 Gallus gallus
471696 Pan troglodytes
513591 Bos taurus
664735 Macaca mulatta
100060348 Equus caballus
100226238 Taeniopygia guttata
100341764 Oryctolagus cuniculus
100435631 Pongo abelii
100471510 Ailuropoda melanoleuca
100591432 Nomascus leucogenys
21453 Mus musculus
6949 Homo sapiens
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