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May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery.
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Ndel1 (Montrer NDEL1 Protéines) acts as a novel upstream regulator of the trichoplein-Aurora A (Montrer AURKA Protéines) pathway to inhibit primary cilia assembly.
These findings underscore the complexity of PGC-1alpha-mediated mitochondrial homeostasis and establish mitostatin as a key regulator of tumor cell mitophagy and angiostasis.
Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 (Montrer ODF1 Protéines) and ninein (Montrer NIN Protéines).
Trichoplein/mitostatin is a new regulator of mitochondria-endoplasmic reticulum juxtaposition.
MITOSTATIN was found within a 3.2-kb transcript for an approximately 62 kDa mitochondrial protein (Montrer COX6B2 Protéines) with tumor suppressor activity. It inhibits cell growth, is proapoptotic and downregulates Hsp27 (Montrer HSPB1 Protéines).
trichoplein is a keratin 8/18-binding protein that may be involved in the organization of the apical network of keratin filaments and desmosomes in simple epithelial cells
MITOSTATIN may acts as a tumor suppressor gene in prostate cancer.
May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity).
trichoplein, keratin filament binding
, mitochondrial protein with oncostatic activity
, trichoplein keratin filament-binding protein
, tumor suppressor protein