Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Kits ELISA

TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. De plus, nous expédions TREM2 Anticorps (192) et TREM2 Protéines (14) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
TREM2 54209 Q9NZC2
TREM2 83433 Q99NH8
TREM2 301227  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain 25.5 pg/mL 62.5 pg/mL - 4000 pg/mL 96 Tests Connectez-vous pour afficher 13 to 16 Days
$589.47
Détails
Souris 6.5 pg/mL 15.6 pg/mL - 1000 pg/mL 96 Tests Connectez-vous pour afficher 13 to 16 Days
$606.32
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Rat 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests Connectez-vous pour afficher 13 to 16 Days
$910.56
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Plus Kits ELISA pour TREM2 partenaires d'interaction

Human Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. Results suggest that TREM2 plays a critical role in inflammation and neuronal cell survival and in neurogenesis. Study showed that TREM2 is a soluble protein transported by macrophages through ventricle walls and choroid plexus, and then enters the brain parenchyma via radial glial cells. TREM2 protein is essential for neuroplasticity and myelination. A lack of TREM2 protein may accelerate aging.

  2. Recent studies have advanced our understanding of TREM2 biology and microglial activities in aging and neurodegenerative brains, providing new insights into TREM2 functions in amyloid plaque maintenance, microglial envelopment of plaque, microglia viability, and the identification of novel TREM2 ligands.

  3. In this meta-analysis, genetic datasets demonstrate that TREM2 is a potent risk factor for Parkinson's Disease.

  4. High amount of TREM2 mRNA expression in leukocytes is specific to SCZ but not MDD and that changes in TREM2 mRNA expression may be a trait biomarker for SCZ.

  5. results indicate that TREM-2 might act as a negative immuno-regulatory molecule...and partially predicts prognosis in lung cancer patients

  6. Authors find, using a cell-free coat protein (Montrer GOLPH3 Kits ELISA) complex II (COPII) vesicle budding reaction, that mutant TREM2 is exported efficiently from the ER. Mutant TREM2 becomes sensitive to cleavage by endoglycosidase D under conditions that inhibit recycling to the ER, indicating that it normally reaches a post-ER compartment.

  7. Mutations in TREM2 gene are known to cause Nasu-Hakola disease.

  8. TREM2 upregulation in the frontal cortex in AD is a late event and may not play a role early in the development of AD pathogenesis and the onset of clinical dementia.

  9. Our results suggest that TREM2 expression is increased in Alzheimer's disease and support previous findings that suggest that p.R47H variant affects TREM2 function by altering binding properties of the receptor rather than expression.

  10. Data show that protein-altering changes are in PLCG2 (Montrer PLCG2 Kits ELISA), ABI3 (Montrer ABI3 Kits ELISA), and TREM2 genes highly expressed in microglia and highlight an immune-related protein-protein interaction network in Alzheimer's disease.

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. Results suggest that TREM2 plays a critical role in inflammation and neuronal cell survival and in neurogenesis. Study showed that TREM2 is a soluble protein transported by macrophages through ventricle walls and choroid plexus, and then enters the brain parenchyma via radial glial cells. TREM2 protein is essential for neuroplasticity and myelination. A lack of TREM2 protein may accelerate aging.

  2. TREM2 deficiency influences both acute and chronic responses to traumatic brain injury, with altered macrophage response early on and improved functional outcome at later time points.

  3. A central role of TREM2 is in the regulation of microglia response to acute neurotoxic insults.

  4. Loss of TREM2 reduces the ability of microglia to engulf amyloid beta-peptide.

  5. TREM2 and TREML2 (Montrer TREML2 Kits ELISA) play opposite roles in microglia activation.

  6. Our study suggests that Vps35 (Montrer vps35 Kits ELISA)/retromer is responsible for recycling of Trem2 in the regulation of microglial function such as proinflammatory responses, whereas R47H mutation impairs Trem2 trafficking, which might contribute to Alzheimer disease.

  7. Microglia in Alzheimer's disease (AD) patients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant autophagic vesicles, as do TREM2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (ER) stress. Study concludes that TREM2 enables microglial responses during AD by sustaining cellular energetic and biosynthetic metabolism.

  8. This study demonstrate a critical role of TREM2-mediated Wnt (Montrer WNT2 Kits ELISA)/beta-catenin (Montrer CTNNB1 Kits ELISA) pathway in microglial viability and suggest that modulating this pathway therapeutically may help to combat the impaired microglial survival.

  9. Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoglobulin-like receptor of the TREM family and is expressed on activated macrophages, immature dendritic cells, osteoclasts, and microglia.

  10. TREM2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation

TREM2 profil antigène

Antigen Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with TREM2

  • triggering receptor expressed on myeloid cells 2 (TREM2) anticorps
  • triggering receptor expressed on myeloid cells 2 (trem2) anticorps
  • trem-like transcript 2 protein (LOC100228399) anticorps
  • triggering receptor expressed on myeloid cells 2 (Trem2) anticorps
  • TREM-2 anticorps
  • TREM-A1 anticorps
  • TREM-B1 anticorps
  • TREM2 anticorps
  • Trem2a anticorps
  • Trem2b anticorps
  • Trem2c anticorps

Protein level used designations for TREM2

triggering receptor expressed on myeloid cells 2 , triggering receptor expressed on monocytes 2 , triggering receptor expressed on myeloid cells 2a , triggering receptor expressed on myeloid cells 2b , triggering receptor expressed on myeloid cells 2c

GENE ID SPECIES
419920 Gallus gallus
748470 Pan troglodytes
100126214 Xenopus (Silurana) tropicalis
100228399 Taeniopygia guttata
719740 Macaca mulatta
54209 Homo sapiens
83433 Mus musculus
301227 Rattus norvegicus
608965 Canis lupus familiaris
100737974 Sus scrofa
506467 Bos taurus
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