Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Kits ELISA

TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. De plus, nous expédions TREM2 Anticorps (194) et TREM2 Protéines (20) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
TREM2 54209 Q9NZC2
TREM2 83433 Q99NH8
TREM2 301227  
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Showing 3 out of 32 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain 25.5 pg/mL 62.5 pg/mL - 4000 pg/mL 96 Tests Connectez-vous pour afficher 13 to 16 Days
$736.84
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Souris 6.5 pg/mL 15.6 pg/mL - 1000 pg/mL 96 Tests Connectez-vous pour afficher 13 to 16 Days
$757.89
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Rat 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests Connectez-vous pour afficher 13 to 16 Days
$910.56
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Plus Kits ELISA pour TREM2 partenaires d'interaction

Human Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. dementia-associated TREM2 mutations have subtle effects on microglia biology, consistent with the adult onset of disease in individuals with these mutations.

  2. This review that the TREM2 regulates innate immunity in Alzheimer's disease.

  3. This study reported genetic associations between TREM2 and neurodegenerative diseases, and the effects of these variants on pathology, clinical presentation, and underlying biology.

  4. This review summarizes studies of association between TREM-1, TREM-2, and malignant tumors in the medical field to provide new ideas for study on the correlation between periodontitis and oral cavity cancer [review]

  5. These results demonstrate that TREM2 interacts with neurons and plaques duing amyloid-beta accumulation and R47H impairs this interaction.

  6. In lung cancer cells, TREM2 gene is regulated by p53 tumor suppressor protein.

  7. Study immunostained the cerebral cortex of 299 participants for TREM2 using the Sigma antibody HPA010917 and compared with the macrophage/microglial markers Iba1 and CD68. As expected, Iba1 and CD68 labeled microglia and perivascular macrophages. However, in most cases (284/299), the TREM2 antibody labelled monocytes within vascular lumens, but not microglia or perivascular macrophages.

  8. These data seem to confirm the protective role of TREM2 in the pre-clinical stage of AD. Upregulation of TREM2 in MCI-AD could be a mechanism to counteract the activation of neuroinflammatory processes.

  9. In the case of rare variants, TREM2 was associated with the rate of dementia progression. TREM2 variant carriers showed a 23% faster rate of dementia compared with non-variant carriers. The recently identified common and rare variants for Alzheimer's disease (AD) susceptibility have a limited impact on the rate of dementia progression in AD patients.

  10. Studies suggest TREM2 plays a key role in Alzheimer disease pathology; however, results have been conflicting about whether TREM2 is beneficial or harmful

  11. Three new structures of WT and R47H mutant TREM2 immunoglobulin-like (Ig-like) domain now reveal that R47 functions to correctly position elements of the ligand-binding surface. Intriguingly, the authors also demonstrate a disruption of receptor oligomerization by the R47H mutation, suggesting a role for ligand-induced clustering in receptor signaling and resultant plaque clearance

  12. TREM2 mRNA and protein expression levels were both significantly higher in gastric cancer compared with normal gastric tissues

  13. Together with in vitro and in vivo characterization, our structural findings elucidate the molecular mechanism underlying loss of ligand binding, putative oligomerization, and functional activity of R47H TREM2. They also help unravel how decreased in vitro and in vivo stability of TREM2 contribute to loss of function in disease.

  14. Trem2 R47H variant activates a cryptic splice site that generates miss-spliced transcripts leading to Trem2 haploinsufficiency only in mice but not in humans

  15. Peripheral TREM2 originating from erythromyeloid cells significantly determines Alzheimer's disease neuropathology in Down syndrome subjects.

  16. Our data establish a critical link between oAbeta1-42, a major pathological component of Alzheimer's disease and TREM2

  17. Data indicate a novel role for PS1 in regulating TREM2 intracellular trafficking and pathophysiological function.

  18. Homozygous TREM2 R47C carrier presenting with an FTD rather than an Alzheimer's disease phenotype.

  19. Our results suggest that deficiency of microglial TREM2 leads to heightened tau pathology coupled with widespread increases in activated neuronal stress kinases

  20. In the current study, we evaluated the rs75932628 polymorphism in the Chinese Han population. However, we did not detect any rs75932628-T in our cohort, indicating that the single nucleotide polymorphism of TREM2 may not be a genetic marker to assess the risk of LOAD in the Chinese Han population.

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. We demonstrate that amyloid plaque seeding is increased in the absence of functional Trem2. Increased seeding is accompanied by decreased microglial clustering around newly seeded plaques and reduced plaque-associated apolipoprotein E (ApoE).

  2. Study shows that loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain.

  3. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.

  4. TREM2 mutation is associated with Alzheimer's disease.

  5. Trem2 R47H variant activates a cryptic splice site that generates miss-spliced transcripts leading to Trem2 haploinsufficiency only in mice but not in humans

  6. Triggering receptor expressed on myeloid cells 2 (TREM2) knockout(-/-) mice displayed repetitive behavior and altered sociability.

  7. Transcriptome analysis revealed that our Trem2-/- mouse line (Velocigene allele) results in exaggerated Treml1 upregulation. In contrast, aberrantly high Treml1 expression was absent in the Trem2 knockout line generated by the Colonna lab and the Jackson Labs CRISPR/Cas9 Trem2 knockout line.

  8. The present study provide novel evidence that overexpression of TREM2 protects against MPTP-induced PD progression via modulation of microglial function through inhibiting TRAF6/TLR4-mediated activation of the MAPK and NF-kappaB signaling pathways.

  9. Our data establish a critical link between oAbeta1-42, a major pathological component of Alzheimer's disease and TREM2

  10. These data suggest that the Alzheimer's disease-associated TREM2 R47H variant increases risk for Alzheimer's disease by conferring a loss of TREM2 function and enhancing neuritic dystrophy around plaques.

  11. Data indicate a novel role for PS1 in regulating TREM2 intracellular trafficking and pathophysiological function.

  12. whereas complete TREM2 deficiency protected against tau-mediated microglial activation and atrophy, TREM2 haploinsufficiency elevated expression of proinflammatory markers and exacerbated atrophy at a late stage of disease. The differential effects of partial and complete loss of TREM2 on microglial function and tau pathology

  13. TREM2 plays a crucial role in altering the proinflammatory M1 microglia to M2 phenotype and has beneficial effects in the immune pathogenesis of Parkinson's disease.

  14. Overexpression of TREM2 downregulated the levels of IL-1beta, ameliorated T396 expression, inhibited the activity of GSK-3beta, and improved sickness behavior. Increased Arg1 expression and a high level of synaptophysin were also observed in the transgenic mice following TREM2 overexpression.

  15. These studies of the role of TREM2 in neuroinflammation and neurodegeneration suggest that impairing microglial TREM2 signaling reduces pure tauopathy.

  16. This article suggests a potential explanation of why TREM2-deficient microglia are unable to respond to neurotoxic plaques in the Alzheimer's disease brain and highlight a further need to understand microglial biology.

  17. TREM2 protects against cerebral ischemia/reperfusion injury through the aspect of post-ischemic inflammatory response and neuronal apoptosis.

  18. Results suggest that TREM2 plays a critical role in inflammation and neuronal cell survival and in neurogenesis. Study showed that TREM2 is a soluble protein transported by macrophages through ventricle walls and choroid plexus, and then enters the brain parenchyma via radial glial cells. TREM2 protein is essential for neuroplasticity and myelination. A lack of TREM2 protein may accelerate aging.

  19. TREM2 deficiency influences both acute and chronic responses to traumatic brain injury, with altered macrophage response early on and improved functional outcome at later time points.

  20. A central role of TREM2 is in the regulation of microglia response to acute neurotoxic insults.

TREM2 profil antigène

Antigen Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with TREM2

  • triggering receptor expressed on myeloid cells 2 (TREM2) anticorps
  • triggering receptor expressed on myeloid cells 2 (trem2) anticorps
  • trem-like transcript 2 protein (LOC100228399) anticorps
  • triggering receptor expressed on myeloid cells 2 (Trem2) anticorps
  • TREM-2 anticorps
  • TREM-A1 anticorps
  • TREM-B1 anticorps
  • TREM2 anticorps
  • Trem2a anticorps
  • Trem2b anticorps
  • Trem2c anticorps

Protein level used designations for TREM2

triggering receptor expressed on myeloid cells 2 , triggering receptor expressed on monocytes 2 , triggering receptor expressed on myeloid cells 2a , triggering receptor expressed on myeloid cells 2b , triggering receptor expressed on myeloid cells 2c

GENE ID SPECIES
419920 Gallus gallus
748470 Pan troglodytes
100126214 Xenopus (Silurana) tropicalis
100228399 Taeniopygia guttata
719740 Macaca mulatta
54209 Homo sapiens
83433 Mus musculus
301227 Rattus norvegicus
608965 Canis lupus familiaris
100737974 Sus scrofa
506467 Bos taurus
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