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TRIM21 encodes a member of the tripartite motif (TRIM) family. De plus, nous expédions TRIM21 Anticorps (100) et TRIM21 Protéines (16) et beaucoup plus de produits pour cette protéine.
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Authors demonstrate that TRIM21 expression predicts survival in pancreatic cancer patients. This work highlights a novel mechanism of Par-4 (Montrer PAWR Kits ELISA) regulation, and identifies a novel prognostic marker and potential therapeutic target for pancreatic cancer.
TRIM21 role in TRAIL-induced apoptosis
Our data suggest that patients with IIM, mainly DM, are characterized by a deficient expression of Ro52/TRIM21 in different PBMC subsets (CD4 (Montrer CD4 Kits ELISA)(+) lymphocytes and monocytes), along with lower K48-mediated ubiquitination, which is associated with a proinflammatory cytokine response.
Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 (Montrer TROVE2 Kits ELISA) and anti-La .
downregulation of miR (Montrer MLXIP Kits ELISA)-1207-5p and miR (Montrer MLXIP Kits ELISA)-4695-3p expression may lead to increased TRIM21 levels in the minor salivary glands, which contributes to the development of Sjogren's syndrome
The interaction of TRIM21 and LFG (Montrer FAIM2 Kits ELISA) was analyzed by co-immunoprecipitation. To examine changes in regulatory processes, western blot analyses, real-time PCR, activity of apoptotic process and flow cytometric analyses were carried out.
TRIM21 plays an essential role in p62-regulated redox homeostasis and may be a viable target for treating pathological conditions resulting from oxidative damage.
TRIM21-induced exposure of the viral genome promotes sensing of DNA and RNA viruses by cGAS and RIG-I (Montrer DDX58 Kits ELISA)
we prove that TRIM21 is a potential tumor suppressor in hepatocellular carcinoma and its low expression indicates poor prognosis
Trim21 regulates Nmi (Montrer MYO1C Kits ELISA)-IFI35 (Montrer IFI35 Kits ELISA) complex-mediated inhibition of innate antiviral response
Antibody affinity modulates TRIM21 immune function. TRIM21 mediates neutralization under suboptimal conditions, whereas induction of immune signaling is balanced according to the functional affinity for the incoming immune stimuli.
Trim21, an estrogen receptor (Montrer ESR1 Kits ELISA) coactivator, induces MYC (Montrer MYC Kits ELISA) oncogene (Montrer RAB1A Kits ELISA) by removing repressive CoAA (Montrer RBM14 Kits ELISA) through E2-dependent degradation of CoAA (Montrer RBM14 Kits ELISA).
results demonstrate that TRIM21 provides potent antiviral protection and forms an important part of the humoral immune response
Simultaneous neutralization and innate immune detection of replicating mouse adenovirus type 1 by TRIM21.
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor (Montrer FCGRT Kits ELISA) TRIM21.
TRIM21 is an interferon (Montrer IFNA Kits ELISA)-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 (Montrer DDX41 Kits ELISA) and negatively regulates the innate immune response to intracellular double-stranded DNA.
analysis of a novel role for tyrosine phosphorylation in regulating the interaction with IRF3 (Montrer IRF3 Kits ELISA) and the activity of TRIM21 downstream of TLR3 (Montrer TLR3 Kits ELISA) and TLR4 (Montrer TLR4 Kits ELISA)
Ro52 is an E3 ligase for interferon (Montrer IFNA Kits ELISA) regulatory factor (IRF)-8 (Montrer IRF8 Kits ELISA) that acts in a non-degradation pathway of ubiquitination and contributes to the elicitation of innate immunity in macrophages.
TRIM21 is a previously undescribed type of IgG receptor based on a non-Ig scaffold whose interaction at the fundamental level-structural, thermodynamic, and kinetic-is evolutionarily conserved.
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
tripartite motif-containing 21
, 52 kDa Ro protein-like
, tripartite motif containing 21
, 52 kDa Ro protein
, 52 kDa ribonucleoprotein autoantigen Ro/SS-A
, E3 ubiquitin-protein ligase TRIM21
, RING finger protein 81
, Sicca syndrome antigen A
, Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)
, sjoegren syndrome type A antigen
, tripartite motif-containing protein 21
, 52kD Ro/SSA autoantigen
, Sjogren syndrome antigen A1
, tripartite motif protein 21