Profil protéine

Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses.

Gene names and symbols associated with Trim30

• tripartite motif-containing 30 (Trim30) anticorps
• tripartite motif-containing 30A (Trim30a) anticorps

• RGD1563970 anticorps
• Rpt-1 anticorps
• Rpt1 anticorps
• Trim30 anticorps

Protein level used designations for Trim30

down regulatory protein of interleukin-2 receptor , regulatory protein, T lymphocyte 1 , tripartite motif protein 30 , tripartite motif-containing 30 , tripartite motif-containing protein 30 , tripartite motif-containing protein 30A