Tripartite Motif Containing 63 Protéines (TRIM63)

TRIM63 encodes a member of the RING zinc finger protein family found in striated muscle and iris. De plus, nous expédions TRIM63 Anticorps (127) et TRIM63 Kits (6) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
TRIM63 84676 Q969Q1
TRIM63 140939 Q91Z63
TRIM63 433766  
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Showing 5 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,955.33
Détails
Escherichia coli (E. coli) Humain Inconjugué   5 applications Connectez-vous pour afficher 1 to 2 Days
$318.85
Détails

TRIM63 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
,
Rat (Rattus) ,

Mouse (Murine) ,

Plus protéines pour Tripartite Motif Containing 63 (TRIM63) partenaires d'interaction

Human Tripartite Motif Containing 63 (TRIM63) interaction partners

  1. role of the muscle specific E3s MuRF-1 and MAFbx in skeletal muscle wasting during various pathologies, as well as their regulation by modifiable lifestyle factors, were explored (review)

  2. the involvement of oxidative stress in the atrophy of COPD peripheral muscle cells in vitro, via the FoxO1/MuRF1/atrogin-1 signaling pathway of the ubiquitin/proteasome system

  3. The mitochondrial damage-cGAS-STING-IRF3 pathway is critically involved in metabolic stress-induced endothelial inflammation.

  4. Altogether, these results suggest a novel function for p63 as a contributor to muscular atrophic processes via the regulation of multiple genes, including the muscle atrophy gene Trim63.

  5. A novel protein aggregate myopathies and cardiomyopathy resulting from combined homozygous MuRF1 null mutation and heterozygous MuRF3 missense mutation.

  6. Vitamin D3 might have an inhibitory effect on the expression of MAFbx and MuRF1 in skeletal muscle.

  7. MURF1 expression intended to be increased in the skeletal muscle of patients with malignant disease even before cancer related cachexia weight loss.

  8. TRIM63 gene expression involved in skin hyperpigmentation.

  9. Expression of USP19 correlates with that of MuRF1 and MAFbx/atrogin-1 in skeletal muscles

  10. Skeletal muscle atrophy induced by Angiotensin II involves activation of MuRF1 expression.

  11. These data strongly supported that rare variants in MuRF1 and MuRF2 are associated with higher penetrance and more severe clinical manifestations of hypertrophic cardiomyopathy.

  12. In conclusion, atrogin-1, MuRF1, FOXO1/3A, and eIF3-f mRNA, and protein levels, are differentially regulated by exercise contraction mode but not WPH supplementation combined with hypertrophy-inducing training.

  13. Data reveal that Titin protein is a pseudokinase with non-detectable catalytic output but is a high-affinity binding locus for MuRF1.

  14. both MuRF1 and MAFbx are enriched in skeletal, cardiac, and smooth muscle--REVIEW

  15. SMAD3 regulates transcription of MuRF-1 by increasing FoxO3 binding at a conserved FRE-SBE motif within the proximal promoter region, and by increasing FoxO3 protein content and transcriptional activity.

  16. In MuRF1 the COS-box mediates the in vivo targeting of sarcoskeletal structures and points to the pharmacological relevance of the COS domain for treating MuRF1-mediated muscle atrophy.

  17. MURF-1 protein gene expression is increased in patients with severe burn injury.

  18. Quadriceps muscle MuRF-1 levels did not differ between patients with COPD (with normal or low fat-free mass index) and controls. MURF1 levels were not associated with quadriceps fiber cross-sectional area or strength in patients.

  19. Regular exercise training leads to a decrease in Rnf28 expression in skeletal muscle in patients with advanced chronic heart failure.

  20. relationship was found between IL-6 and MuRF-1 expression after incubation with PGE2

Mouse (Murine) Tripartite Motif Containing 63 (TRIM63) interaction partners

  1. Oligonol-mediated downregulation of Atrogin-1 and MuRF1 gene expression alleviates muscle loss and improves the impaired myotube formation, indicating that oligonol supplementation may be useful for the attenuation of myotube loss.

  2. the present study indicates that excessive glucocorticoids increased ubiquitin-proteasome system -dependent protein proteolysis via stimulating MuRF1, but not atrogin-1.

  3. Dexamethasone-induced MuRF1 upregulation was significantly attenuated in C2C12 myotubes by resveratrol in vitro, but this effect on C2C12 myotubes was abrogated by a knockdown of NF-kappaB, suggesting that the beneficial effect of resveratrol was NF-kappaB dependent. Our findings provide novel information about the ability of resveratrol to prevent or treat muscle atrophy induced by CKD.

  4. Iron-induced skeletal muscle atrophy is suggested to involve the E3 ubiquitin ligase mediated by the reduction of Akt-FOXO3a signaling by oxidative stress.

  5. MAFbx mRNA expression was decreased in old mice relative to adult mice, whereas MuRF1 mRNA expression was less affected by ageing

  6. MuRF1 directly interacts with PPARalpha, mono-ubiquitinates it, and targets it for nuclear export to inhibit fatty acid oxidation in a proteasome independent manner.

  7. Increased Expression of MuRF1 Is Associated with Radiation-induced Laryngeal Muscle Atrophy.

  8. MURF1 was upregulated in cancer cachexia mice.

  9. Expression of USP19 correlates with that of MuRF1 and MAFbx/atrogin-1 in skeletal muscles

  10. Sunitinib is able to restrain the overactivation of STAT3 and MuRF-1 pathways, involved in enhanced muscle protein catabolism during cancer cachexia.

  11. provide evidence that high CO2 activates skeletal muscle atrophy via AMPKalpha2-FoxO3a-MuRF1, which is of biological and potentially clinical significance in patients with lung diseases and hypercapnia

  12. an atrophic role for MuRF1 regulating the magnitude of right ventricular hypertrophy

  13. This data provides evidence for MuRF1 as a novel regulator of cardiac ROS, offering another mechanism by which increased MuRF1 expression may be cardioprotective in ischemia reperfusion injury.

  14. Data reveal that Titin protein is a pseudokinase with non-detectable catalytic output but is a high-affinity binding locus for MuRF1.

  15. MuRF1 plays an important role in the control of skeletal muscle mass and growth capacity through the regulation of cellular stress.

  16. Elevated reactive oxygen species in Smad3 deficient muscle potentiates binding of C/EBP homology protein transcription factor to MuRF1 promoter and enhanced MuRF1 levels leading to muscle atrophy.

  17. MuRF1 and MuRF2 play a redundant role in regulating developmental physiologic hypertrophy, by regulating E2F transcription factors essential for normal cardiac development and by supporting E2F localization to the nucleus, but not through degradation.

  18. The lack of MuRF1 expression in the PCA suggests a previously unrecognized mechanism whereby this muscle is spared from atrophy.

  19. mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.

  20. Muscle-specific RING finger 1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin A.

Pig (Porcine) Tripartite Motif Containing 63 (TRIM63) interaction partners

  1. this study shows that aspartate suppresses lipopolysaccharide-induced MuRF1 expression in skeletal muscle via activation of Akt signaling, and inhibition of AMPKa and FOXO1 signaling

Zebrafish Tripartite Motif Containing 63 (TRIM63) interaction partners

  1. The findings reveal a novel mechanism by which Ca2+ overload disrupts myofibril integrity by activating a Calcineurin-FoxO-MuRF1-proteosome signaling pathway.

Profil protéine TRIM63

Profil protéine

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase.

Gene names and symbols associated with TRIM63

  • tripartite motif containing 63 (TRIM63)
  • tripartite motif containing 63 (Trim63)
  • tripartite motif-containing 63 (Trim63)
  • tripartite motif containing 63 S homeolog (trim63.S)
  • tripartite motif-containing 63 (TRIM63)
  • tripartite motif containing 63a (trim63a)
  • fc50c07 Protéine
  • IRF Protéine
  • MGC80210 Protéine
  • MuRF Protéine
  • MuRF1 Protéine
  • MURF2 Protéine
  • RF1 Protéine
  • Rnf28 Protéine
  • rnf30 Protéine
  • SMRZ Protéine
  • trim63 Protéine
  • wu:fc50c07 Protéine
  • zgc:86757 Protéine

Protein level used designations for TRIM63

E3 ubiquitin-protein ligase TRIM63 , iris ring finger protein , muscle specific ring finger protein 2 , muscle-specific RING finger protein 1 , ring finger protein 28 , striated muscle RING zinc finger protein , tripartite motif-containing protein 63 , MURF-1 , muscle ring finger protein 1 , tripartite motif protein 63 , tripartite motif-containing 63 , ring finger protein 30 , muscle specific ring finger protein 1 , muscle specific RING finger protein-1 , e3 ubiquitin-protein ligase TRIM63-like , tripartite motif containing 63 , MuRF1A , murf1 , tripartite motif containing 63a

GENE ID SPECIES
84676 Homo sapiens
140939 Rattus norvegicus
426754 Gallus gallus
433766 Mus musculus
446518 Xenopus laevis
469240 Pan troglodytes
487362 Canis lupus familiaris
528912 Bos taurus
713802 Macaca mulatta
100144767 Ovis aries
100221817 Taeniopygia guttata
100431101 Sus scrofa
100483233 Ailuropoda melanoleuca
100581509 Nomascus leucogenys
100716828 Cavia porcellus
415223 Danio rerio
100071234 Equus caballus
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