Tumor Protein P53 Binding Protein 2 Protéines (TP53BP2)

TP53BP2 encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. De plus, nous expédions Tumor Protein P53 Binding Protein 2 Anticorps (77) et Tumor Protein P53 Binding Protein 2 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
TP53BP2 7159 Q13625
TP53BP2 209456 Q8CG79
Rat TP53BP2 TP53BP2 305025  
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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TP53BP2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Tumor Protein P53 Binding Protein 2 (TP53BP2) partenaires d'interaction

Human Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. These findings identify TP53BP2 as a strong candidate causative gene for central nervous system (CNS) defects in 1q41q42 microdeletion syndrome.

  2. Results showed that protein expression levels of ASPP2 and P53 (Montrer TP53 Protéines) were significantly higher in esophageal squamous cell carcinoma tissues than in paired noncancerous tissues.

  3. Expression levels of TP53BP2, FBXO28 (Montrer FBXO28 Protéines), and FAM53A (Montrer Fam53a Protéines) genes were associated with patient survival specifically in ER-positive, TP53 (Montrer TP53 Protéines)-mutated tumors.

  4. These data together implicated a critical impact of MiR (Montrer MLXIP Protéines)-205/ASPP2 on promoting epithelial-mesenchymal transition.

  5. ASPP2 is a key regulator of BECN1 (Montrer BECN1 Protéines)-dependent autophagy.

  6. ASPP2 suppresses invasion, peritoneal dissemination and TGF-beta1 (Montrer TGFB1 Protéines)-induced EMT (Montrer ITK Protéines) by inhibiting Smad7 (Montrer SMAD7 Protéines) degradation mediated by ITCH in gastric cancer cells.

  7. Our results suggest that Gal-1 and ASPP2 functionally compete in nanocluster for active Ras on the plasma membrane. ASPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.

  8. ASPP2 suppresses p53 (Montrer TP53 Protéines) target gene transactivation, promoter occupancy, and endogenous p53 (Montrer TP53 Protéines) target gene expression in response to DNA damage

  9. In this study, in recombinant adenovirus-ASPP2-infected HepG2 cells, ASPP2 overexpression induces amphiregulin (Montrer AREG Protéines) expression in a p53 (Montrer TP53 Protéines)-dependent manner

  10. Downregulated expression of ASPP2 is associated with hepatocellular carcinoma.

Zebrafish Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. These findings uncover a novel role of Aspp2 in regulating vertebrate embryonic growth.

Mouse (Murine) Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. These results suggest that ASPP2 plays an important role in p53 (Montrer TP53 Protéines)-mediated neuronal apoptosis under gp120 (Montrer ITIH4 Protéines) stress.

  2. These findings identify TP53BP2 as a strong candidate causative gene for central nervous system (CNS) defects in 1q41q42 microdeletion syndrome.

  3. SPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.

  4. ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure.

  5. ASPP2 prevents beta-catenin (Montrer CTNNB1 Protéines) from transactivating ZEB1 directly by forming an ASPP2-beta-catenin (Montrer CTNNB1 Protéines)-E-cadherin (Montrer CDH1 Protéines) ternary complex

  6. findings suggest that the identified STAT1 (Montrer STAT1 Protéines)/ASPP2 pathway may connect tumor suppression and cell polarity to neuroinflammation

  7. our studies demonstrate the role of Siah2 (Montrer SIAH2 Protéines) in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 stability.

  8. ASPP2 is a tumor suppressor that suppresses squamous cell carcinoma via inflammatory signaling through NF-kappaB (Montrer NFKB1 Protéines)-mediated repression of p63 (Montrer CKAP4 Protéines).

  9. Our study demonstrates a novel role for ASPP1 (Montrer PPP1R13B Protéines) and ASPP2 in the death of retinal ganglion cells.

  10. regulates epithelial cell polarity in cooperation with PAR-3 (Montrer F2RL2 Protéines) to form an active PAR (Montrer AFG3L2 Protéines) complex

Profil protéine Tumor Protein P53 Binding Protein 2 (TP53BP2)

Profil protéine

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TP53BP2

  • tumor protein p53 binding protein 2 (TP53BP2)
  • tumor protein p53 binding protein 2 L homeolog (tp53bp2.L)
  • tumor protein p53 binding protein 2 (tp53bp2)
  • tumor protein p53 binding protein, 2b (tp53bp2b)
  • transformation related protein 53 binding protein 2 (Trp53bp2)
  • tumor protein p53 binding protein, 2 (Tp53bp2)
  • tumor protein p53 binding protein, 2a (tp53bp2a)
  • tumor protein p53 binding protein 2 (Tp53bp2)
  • 53BP2 Protéine
  • AI746547 Protéine
  • ASPP2 Protéine
  • BBP Protéine
  • P53BP2 Protéine
  • PPP1R13A Protéine
  • Tp53bp2 Protéine
  • Trp53bp2 Protéine
  • wu:fa09h08 Protéine
  • wu:fb04e08 Protéine
  • X98550 Protéine
  • zgc:85720 Protéine

Protein level used designations for TP53BP2

BCL2-binding protein , apoptosis-stimulating of p53 protein 2 , apoptosis-stimulating protein of p53, 2 , renal carcinoma antigen NY-REN-51 , tumor suppressor p53-binding protein 2 , tumor protein p53 binding protein, 2 , apoptosis-stimulating of p53 protein 2-like , p53-binding protein 2 , p53BP2 , transformation related protein 53 binding protein 2 , fb04e08

GENE ID SPECIES
7159 Homo sapiens
421329 Gallus gallus
446947 Xenopus laevis
457766 Pan troglodytes
490397 Canis lupus familiaris
514474 Bos taurus
548790 Xenopus (Silurana) tropicalis
568138 Danio rerio
705383 Macaca mulatta
100055278 Equus caballus
100221962 Taeniopygia guttata
100445132 Pongo abelii
100519863 Sus scrofa
209456 Mus musculus
305025 Rattus norvegicus
407983 Danio rerio
100732221 Cavia porcellus
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