Tumor Protein P53 Binding Protein 2 Protéines (TP53BP2)

TP53BP2 encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. De plus, nous expédions Tumor Protein P53 Binding Protein 2 Anticorps (81) et Tumor Protein P53 Binding Protein 2 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
TP53BP2 7159 Q13625
TP53BP2 209456 Q8CG79
Rat TP53BP2 TP53BP2 305025  
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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TP53BP2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Tumor Protein P53 Binding Protein 2 (TP53BP2) partenaires d'interaction

Human Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. Study have provided evidence that ASPP2 has an inhibitory influence on triplenegative breast cancer (TNBC) growth and metastasis, and that this may rely on using the PI3K/AKT pathway in a p53independent manner.

  2. the abnormal expression of ASPP2 may play an important role for development and metastasis in esophageal squamous cell carcinoma.

  3. These findings identify TP53BP2 as a strong candidate causative gene for central nervous system (CNS) defects in 1q41q42 microdeletion syndrome.

  4. Results showed that protein expression levels of ASPP2 and P53 were significantly higher in esophageal squamous cell carcinoma tissues than in paired noncancerous tissues.

  5. Expression levels of TP53BP2, FBXO28, and FAM53A genes were associated with patient survival specifically in ER-positive, TP53-mutated tumors.

  6. These data together implicated a critical impact of MiR-205/ASPP2 on promoting epithelial-mesenchymal transition.

  7. ASPP2 is a key regulator of BECN1-dependent autophagy.

  8. ASPP2 suppresses invasion, peritoneal dissemination and TGF-beta1-induced EMT by inhibiting Smad7 degradation mediated by ITCH in gastric cancer cells.

  9. Our results suggest that Gal-1 and ASPP2 functionally compete in nanocluster for active Ras on the plasma membrane. ASPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.

  10. ASPP2 suppresses p53 target gene transactivation, promoter occupancy, and endogenous p53 target gene expression in response to DNA damage

  11. In this study, in recombinant adenovirus-ASPP2-infected HepG2 cells, ASPP2 overexpression induces amphiregulin expression in a p53-dependent manner

  12. Downregulated expression of ASPP2 is associated with hepatocellular carcinoma.

  13. miR-548d-3p/TP53BP2 pathway is critically involved in the proliferation and apoptosis of breast cancer cells and may be new therapeutic target of breast cancer cells.

  14. ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.

  15. ASSP2 expression is lower in cancerous tissues and decreased ASPP2 lead to higher cancer cells proliferation and autophagic flux, which contribute to the gemcitabine resistance.

  16. this study revealed a novel function of ASPP2 in modulating autophagy and apoptosis.

  17. ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure.

  18. These results identify previously uncharacterized regions distributed throughout the protein sequence of ASPP2 as determinants of CagA binding, providing mechanistic insight into apoptosis reprogramming by CagA.

  19. ASPP2 directly induces the dephosphorylation and activation of junctional YAP

  20. CHOP is critical for mediating ASPP2-induced autophagic apoptosis by decreasing Bcl-2 expression and maintaining nuclear ASPP2-Bcl-2 complexes.

Zebrafish Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. These findings uncover a novel role of Aspp2 in regulating vertebrate embryonic growth.

Mouse (Murine) Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. These results suggest that ASPP2 plays an important role in p53-mediated neuronal apoptosis under gp120 stress.

  2. These findings identify TP53BP2 as a strong candidate causative gene for central nervous system (CNS) defects in 1q41q42 microdeletion syndrome.

  3. SPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.

  4. ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure.

  5. ASPP2 prevents beta-catenin from transactivating ZEB1 directly by forming an ASPP2-beta-catenin-E-cadherin ternary complex

  6. findings suggest that the identified STAT1/ASPP2 pathway may connect tumor suppression and cell polarity to neuroinflammation

  7. our studies demonstrate the role of Siah2 in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 stability.

  8. ASPP2 is a tumor suppressor that suppresses squamous cell carcinoma via inflammatory signaling through NF-kappaB-mediated repression of p63.

  9. Our study demonstrates a novel role for ASPP1 and ASPP2 in the death of retinal ganglion cells.

  10. regulates epithelial cell polarity in cooperation with PAR-3 to form an active PAR complex

  11. Consistent with its role in cell polarity, ASPP2 influences interkinetic nuclear migration and lamination during CNS development.

  12. ASPP2 is a haploinsufficient tumor suppressor that shares overlapping function(s) with p53 in mouse development and tumor suppression.

  13. 53BP2S interacts and modulates the insulin signals mediated by insulin receptor substrates.

  14. ASPP2(+/-) mice appeared developmentally normal, they displayed an increased incidence of a variety of spontaneous tumors as they aged

  15. [review] potential ASPP2-mediated pathways found by gene expression profiling

Profil protéine Tumor Protein P53 Binding Protein 2 (TP53BP2)

Profil protéine

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TP53BP2

  • tumor protein p53 binding protein 2 (TP53BP2)
  • tumor protein p53 binding protein 2 L homeolog (tp53bp2.L)
  • tumor protein p53 binding protein 2 (tp53bp2)
  • tumor protein p53 binding protein, 2b (tp53bp2b)
  • transformation related protein 53 binding protein 2 (Trp53bp2)
  • tumor protein p53 binding protein, 2 (Tp53bp2)
  • tumor protein p53 binding protein, 2a (tp53bp2a)
  • tumor protein p53 binding protein 2 (Tp53bp2)
  • 53BP2 Protéine
  • AI746547 Protéine
  • ASPP2 Protéine
  • BBP Protéine
  • P53BP2 Protéine
  • PPP1R13A Protéine
  • Tp53bp2 Protéine
  • Trp53bp2 Protéine
  • wu:fa09h08 Protéine
  • wu:fb04e08 Protéine
  • X98550 Protéine
  • zgc:85720 Protéine

Protein level used designations for TP53BP2

BCL2-binding protein , apoptosis-stimulating of p53 protein 2 , apoptosis-stimulating protein of p53, 2 , renal carcinoma antigen NY-REN-51 , tumor suppressor p53-binding protein 2 , tumor protein p53 binding protein, 2 , apoptosis-stimulating of p53 protein 2-like , p53-binding protein 2 , p53BP2 , transformation related protein 53 binding protein 2 , fb04e08

GENE ID SPECIES
7159 Homo sapiens
421329 Gallus gallus
446947 Xenopus laevis
457766 Pan troglodytes
490397 Canis lupus familiaris
514474 Bos taurus
548790 Xenopus (Silurana) tropicalis
568138 Danio rerio
705383 Macaca mulatta
100055278 Equus caballus
100221962 Taeniopygia guttata
100445132 Pongo abelii
100519863 Sus scrofa
209456 Mus musculus
305025 Rattus norvegicus
407983 Danio rerio
100732221 Cavia porcellus
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