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TP53BP2 encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. De plus, nous expédions Tumor Protein P53 Binding Protein 2 Anticorps (77) et Tumor Protein P53 Binding Protein 2 Kits (4) et beaucoup plus de produits pour cette protéine.
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These findings identify TP53BP2 as a strong candidate causative gene for central nervous system (CNS) defects in 1q41q42 microdeletion syndrome.
Results showed that protein expression levels of ASPP2 and P53 (Montrer TP53 Protéines) were significantly higher in esophageal squamous cell carcinoma tissues than in paired noncancerous tissues.
Expression levels of TP53BP2, FBXO28 (Montrer FBXO28 Protéines), and FAM53A (Montrer Fam53a Protéines) genes were associated with patient survival specifically in ER-positive, TP53 (Montrer TP53 Protéines)-mutated tumors.
These data together implicated a critical impact of MiR (Montrer MLXIP Protéines)-205/ASPP2 on promoting epithelial-mesenchymal transition.
ASPP2 is a key regulator of BECN1 (Montrer BECN1 Protéines)-dependent autophagy.
ASPP2 suppresses invasion, peritoneal dissemination and TGF-beta1 (Montrer TGFB1 Protéines)-induced EMT (Montrer ITK Protéines) by inhibiting Smad7 (Montrer SMAD7 Protéines) degradation mediated by ITCH in gastric cancer cells.
Our results suggest that Gal-1 and ASPP2 functionally compete in nanocluster for active Ras on the plasma membrane. ASPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.
ASPP2 suppresses p53 (Montrer TP53 Protéines) target gene transactivation, promoter occupancy, and endogenous p53 (Montrer TP53 Protéines) target gene expression in response to DNA damage
In this study, in recombinant adenovirus-ASPP2-infected HepG2 cells, ASPP2 overexpression induces amphiregulin (Montrer AREG Protéines) expression in a p53 (Montrer TP53 Protéines)-dependent manner
Downregulated expression of ASPP2 is associated with hepatocellular carcinoma.
These findings uncover a novel role of Aspp2 in regulating vertebrate embryonic growth.
These results suggest that ASPP2 plays an important role in p53 (Montrer TP53 Protéines)-mediated neuronal apoptosis under gp120 (Montrer ITIH4 Protéines) stress.
SPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.
ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure.
ASPP2 prevents beta-catenin (Montrer CTNNB1 Protéines) from transactivating ZEB1 directly by forming an ASPP2-beta-catenin (Montrer CTNNB1 Protéines)-E-cadherin (Montrer CDH1 Protéines) ternary complex
findings suggest that the identified STAT1 (Montrer STAT1 Protéines)/ASPP2 pathway may connect tumor suppression and cell polarity to neuroinflammation
our studies demonstrate the role of Siah2 (Montrer SIAH2 Protéines) in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 stability.
ASPP2 is a tumor suppressor that suppresses squamous cell carcinoma via inflammatory signaling through NF-kappaB (Montrer NFKB1 Protéines)-mediated repression of p63 (Montrer CKAP4 Protéines).
Our study demonstrates a novel role for ASPP1 (Montrer PPP1R13B Protéines) and ASPP2 in the death of retinal ganglion cells.
regulates epithelial cell polarity in cooperation with PAR-3 (Montrer F2RL2 Protéines) to form an active PAR (Montrer AFG3L2 Protéines) complex
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.
, apoptosis-stimulating of p53 protein 2
, apoptosis-stimulating protein of p53, 2
, renal carcinoma antigen NY-REN-51
, tumor suppressor p53-binding protein 2
, tumor protein p53 binding protein, 2
, apoptosis-stimulating of p53 protein 2-like
, p53-binding protein 2
, transformation related protein 53 binding protein 2