anti-Tumor Protein P63 (TP63) Anticorps

TP63 encodes a member of the p53 family of transcription factors. De plus, nous expédions p63 Kits (31) et p63 Protéines (10) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TP63 8626 Q9H3D4
TP63 246334 Q9JJP6
TP63 22061 O88898
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Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB TP63 Antibody (C-term) (ABIN657886) western blot analysis in MDA-MB231 cell line lysates (35 µg/lane). This demonstrates the TP63 antibody detected the TP63 protein (arrow). Anti-TP63 Antibody (C-term) at 1:1000 dilution + HACAT whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 77 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL Connectez-vous pour afficher 10 to 11 Days
Humain Lapin Inconjugué ICC, IHC (p), WB Anti-p63 Picoband antibody,  IHC(P): Human Oesophagus Squama Cancer Tissue Anti-p63 Picoband antibody,  All lanes: Anti P63  at 0.5ug/ml WB: Recombinant Human P63 Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD 100 μg Connectez-vous pour afficher 4 to 6 Days
Humain Chèvre Inconjugué ELISA, WB 0.1 mg Connectez-vous pour afficher 2 to 3 Days
Humain Lapin Inconjugué ICC, IHC (p), WB Anti-p63 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue Anti-p63 antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: SMMC Cell Lysate Lane 3: COLO320 Cell Lysate Lane 4: A549 Cell Lysate Lane 5: SGC Cell Lysate 100 μg Connectez-vous pour afficher 4 to 6 Days
Humain Lapin Inconjugué IHC, WB Immunohistochemistry of paraffin-embedded rat kidney using TP63 antibody at dilution of 1:100 (x400 lens). 100 μL Connectez-vous pour afficher 16 Days
Humain Souris Inconjugué WB TP63 Antibody (Ascites) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TP63 antibody detected the TP63 protein (arrow). 0.1 mL Connectez-vous pour afficher 10 to 11 Days
Humain Souris Inconjugué ELISA, WB Detection limit for recombinant GST tagged TP73L is approximately 0.3 ng/mL as a capture antibody. Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 100 μg Connectez-vous pour afficher 8 to 11 Days
Humain Souris Inconjugué ELISA, WB 200 μL Connectez-vous pour afficher 12 to 14 Days
Humain Lapin Inconjugué IHC (p) Immunochemical staining of human P63 in human skin with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections). Immunochemical staining of human P63 in human prostate with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections). 100 μg Connectez-vous pour afficher 20 to 21 Days
Humain Lapin Inconjugué WB Human p63 / TP63 Western blot (WB) 13067 100 μg Connectez-vous pour afficher 20 to 21 Days

TP63 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Human , , ,
, ,
, , , , ,
Rat (Rattus) , ,
Mouse (Murine) , ,

anti-p63 Anticorps mieux référencés

  1. Human Polyclonal p63 Primary Antibody pour WB - ABIN657886 : Miki, Kubo, Takahashi, Yoon, Kim, Lee, Zo, Lee, Hosono, Morizono, Tsunoda, Kamatani, Chayama, Takahashi, Inazawa, Nakamura, Daigo: Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. dans Nature genetics 2010 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre p63 partenaires d’interaction

Human Tumor Protein P63 (TP63) interaction partners

  1. Gene-gene interaction between MSX1 (Montrer MSX1 Anticorps) and TP63 may influence the risk of nonsyndromic cleft lip with or without cleft palate in Asian populations.

  2. High N-terminally truncated isoform of p63 (Montrer RPE65 Anticorps) expression is associated with squamous cell carcinogenesis.

  3. The rs35592567 polymorphism in TP63 affected the expression of TP63 by interfering with its interaction with miR (Montrer MLXIP Anticorps)-140, and could serve as an explanation for the increased risk of Gastric Cancer.

  4. The data from this study showed that p63 was a tumor suppressor mainly through regulating PTEN in chondrosarcoma cells.

  5. we first demonstrated that upregulation of P63 (Montrer RPE65 Anticorps) in the cartilage tissues of osteoarthritis (OA) patients inhibited chondrocyte autophagy thereby contributing to the malignant progression of OA.

  6. high DeltaNp63beta expression up-regulates KLK6 (Montrer KLK1 Anticorps)-PAR2 (Montrer F2RL1 Anticorps) and down-regulates PAR1 (Montrer MARK2 Anticorps), inducing malignant transformation in oral epithelium with stimulating proliferation through ERK (Montrer EPHB2 Anticorps) signal activation

  7. multiple ankyloblepharon-ectodermal defects-cleft lip/palate syndrome-associated p63 (Montrer RPE65 Anticorps) mutations, but not those causative of other diseases, lead to thermodynamic protein destabilization, misfolding, and aggregation

  8. LINC01503 is increased in squamous cell carcinoma (SCC (Montrer CYP11A1 Anticorps)) cells compared with non-tumor cells. TP63 bound to the super enhancer at the LINC01503 locus activates its transcription which promotes SCC (Montrer CYP11A1 Anticorps) cell proliferation, migration, invasion, and growth of xenograft tumors.

  9. we provide evidence that S100A7 (Montrer S100A7 Anticorps) also inhibits YAP (Montrer YAP1 Anticorps) expression and activity through p65 (Montrer GORASP1 Anticorps)/NFkappaB (Montrer NFKB1 Anticorps)-mediated repression of DeltaNp63, and S100A7 (Montrer S100A7 Anticorps) represses drug-induced apoptosis via inhibition of YAP (Montrer YAP1 Anticorps).

  10. DeltaNp63 promotes head and neck squamous cell carcinoma tumorigenesis via regulation of hyaluronic acid metabolism. p63 (Montrer RPE65 Anticorps) expression is a negative prognostic factor of HNSCC patient survival.

Horse (Equine) Tumor Protein P63 (TP63) interaction partners

  1. p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses

Zebrafish Tumor Protein P63 (TP63) interaction partners

  1. they unravel essential roles of TAp63 and p53 (Montrer TP53 Anticorps) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (Montrer NOTCH1 Anticorps) signalling and caspase 3 (Montrer CASP3 Anticorps) activity.

  2. the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (Montrer BBC3 Anticorps) transcription in response to ER stress.

  3. Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)

  4. DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)

  5. rps19 (Montrer RPS19 Anticorps)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (Montrer TP53 Anticorps) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia

Mouse (Murine) Tumor Protein P63 (TP63) interaction partners

  1. The results indicate that ZIP10 (Montrer SLC39A10 Anticorps) plays important roles in epidermal development via, at least in part, the ZIP10 (Montrer SLC39A10 Anticorps)-zinc-p63 (Montrer CKAP4 Anticorps) signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis.

  2. Notch signaling maintains p63 levels and horizontal basal cell (HBC) dormancy, in contrast to its suppression of p63 expression in other tissues. Additionally, Notch1, but not Notch2, is required to maintain HBC dormancy after selective neuronal degeneration.

  3. present study, we provided a role for IDH2 (Montrer IDH2 Anticorps) in protection against UVB-induced skin damage and a new connection between IDH2 (Montrer IDH2 Anticorps) and DeltaNp63.

  4. Overexpression of DeltaNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with Atopic dermatitis and IL-31 (Montrer IL31 Anticorps) and IL-33 (Montrer IL33 Anticorps) are key players in the signaling pathways.

  5. cells expressing both p63 (Montrer CKAP4 Anticorps) and p73 (Montrer ARHGAP24 Anticorps) exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.

  6. Data suggest that this the selective targeting of genes by tumor suppressor protein (Montrer TP53 Anticorps) p63 (p63 (Montrer CKAP4 Anticorps)) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends.

  7. p63alpha protein up-regulates heat shock protein 70 (Montrer HSP70 Anticorps) expression via E2F1 transcription factor (Montrer E2F1 Anticorps) 1 (Montrer HNF1A Anticorps), promoting Wasf3/Wave3 (Montrer WASF3 Anticorps)/MMP9 (Montrer MMP9 Anticorps) signaling and bladder cancer invasion

  8. these results therefore highlight an unanticipated role for p53 (Montrer TP53 Anticorps) family proteins in a regulatory network that integrates essential Wnt (Montrer WNT2 Anticorps)-Tcf (Montrer HNF4A Anticorps) and nodal-Smad (Montrer SMAD1 Anticorps) inputs.

  9. the double mutant spermatocytes apoptosed at late pachynema because of sex body deficiency; thus p53 (Montrer TP53 Anticorps) and TAp63 are dispensable for arrest caused by sex body defects. These data affirm that recombination-dependent and sex body-deficient arrests occur via genetically separable mechanisms.

  10. TGFb3 (Montrer TGFB3 Anticorps)-induced down-regulation of p63 (Montrer CKAP4 Anticorps) in the medial edge epithelia of the palatal shelves is a pre-requisite for palatal fusion by facilitating periderm migration from, and reducing the proliferative potential of, the midline epithelial seam thereby preventing cleft palate.

Xenopus laevis Tumor Protein P63 (TP63) interaction partners

  1. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  2. The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (Montrer BMP4 Anticorps).

  3. The role of p63 as a negative Wnt (Montrer WNT2 Anticorps)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.

p63 (TP63) profil antigène

Profil protéine

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Gene names and symbols associated with anti-Tumor Protein P63 (TP63) Anticorps

  • tumor protein p63 (TP63) anticorps
  • tumor protein p63 (tp63) anticorps
  • tumor protein p63 (Tp63) anticorps
  • transformation related protein 63 (Trp63) anticorps
  • tumor protein p63 L homeolog (tp63.L) anticorps
  • AI462811 anticorps
  • AIS anticorps
  • B(p51A) anticorps
  • B(p51B) anticorps
  • DNp63 anticorps
  • EEC3 anticorps
  • id:ibd3516 anticorps
  • ket anticorps
  • LMS anticorps
  • NBP anticorps
  • np63 anticorps
  • OFC8 anticorps
  • p40 anticorps
  • p51 anticorps
  • P51/P63 anticorps
  • p53CP anticorps
  • P63 anticorps
  • p73H anticorps
  • P73l anticorps
  • RHS anticorps
  • SHFM4 anticorps
  • TP53CP anticorps
  • TP53L anticorps
  • Tp63 anticorps
  • Tp73l anticorps
  • tp73l-A anticorps
  • Trp53rp1 anticorps
  • trp63 anticorps
  • wu:fc89f04 anticorps
  • wu:fk85h07 anticorps
  • wu:fk88b02 anticorps
  • Xp63 anticorps

Protein level used designations for anti-Tumor Protein P63 (TP63) Anticorps

CUSP , amplified in squamous cell carcinoma , chronic ulcerative stomatitis protein , keratinocyte transcription factor KET , transformation-related protein 63 , tumor protein 63 , tumor protein p53-competing protein , tumor protein p63 deltaN isoform delta , tumor protein p63 , delta-Np63 , fc89f04 , transformation related protein 63 , tumor protein 63 kDa , tumor protein 63-like

8626 Homo sapiens
100059752 Equus caballus
100170632 Oryzias latipes
260407 Danio rerio
703997 Macaca mulatta
615335 Bos taurus
246334 Rattus norvegicus
374269 Gallus gallus
460930 Pan troglodytes
488125 Canis lupus familiaris
100227936 Taeniopygia guttata
100386953 Callithrix jacchus
100444448 Pongo abelii
100606847 Nomascus leucogenys
22061 Mus musculus
373640 Xenopus laevis
100625258 Sus scrofa
100355881 Oryctolagus cuniculus
100732143 Cavia porcellus
101108874 Ovis aries
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