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TP63 encodes a member of the p53 family of transcription factors. De plus, nous expédions p63 Anticorps (77) et p63 Protéines (7) et beaucoup plus de produits pour cette protéine.
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the strong repression of Np63 by H-RAS (Montrer HRAS Kits ELISA) and PIK3CA (Montrer PIK3CA Kits ELISA) and induction of EMT (Montrer ITK Kits ELISA) suggest that this process is critical for mammary tumorigenesis.
This study suggests that in patients with CD30 (Montrer TNFRSF8 Kits ELISA)+ lymphoproliferative disorders, an aggressive clinical course cannot be defined by the presence of TP63 rearrangements, as was recently shown in systemic ALK (Montrer ALK Kits ELISA) negative anaplastic large cell lymphoma.
This study revealed the possible association between TP63 and Mullerian duct anomalies and suggested a potential contribution of microRNA-regulated expression of genes in the etiology of Mullerian duct anomalies.
We identified a list of thirty genes repressed by DeltaNp63 in a SETDB1 (Montrer SETDB1 Kits ELISA)-dependent manner, whose expression is positively correlated to survival of breast cancer patients. These results suggest that p63 (Montrer RPE65 Kits ELISA) and SETDB1 (Montrer SETDB1 Kits ELISA) expression, together with the repressed genes, may have diagnostic and prognostic potential
Dysregulation of JAM-A (Montrer F11R Kits ELISA) via p63 (Montrer RPE65 Kits ELISA)/GATA-3 (Montrer GATA3 Kits ELISA) signaling pathway occurs in squamous cell carcinomas of the head and neck.
This study investigated the expression of p40 (Montrer IL9 Kits ELISA) protein in meningiomas and explored its usefulness as prognostic marker in addition to PgR (Montrer PGR Kits ELISA) and Ki67 (Montrer MKI67 Kits ELISA).
the transactivation inhibitory (TI) domains within the alpha-isoform-specific C termini of p63 (Montrer RPE65 Kits ELISA) and p73 (Montrer TP73 Kits ELISA) are essential for binding to p53R175H.
Data show that a two-marker panel of p40 (Montrer IL9 Kits ELISA) (DeltaNp63) and CDX2 (Montrer CDX2 Kits ELISA) is highly sensitive and specific.
DeltaNp63alpha (TP63) is co-expressed with FAT2 and Slug in patient tumors and the elevated expression of DeltaNp63alpha, FAT2 and Slug correlated with poor patient outcome.
Keratin14/p63 (Montrer RPE65 Kits ELISA)-positive epithelial proliferations suggest benign breast disease.
p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses
they unravel essential roles of TAp63 and p53 (Montrer TP53 Kits ELISA) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (Montrer NOTCH1 Kits ELISA) signalling and caspase 3 (Montrer CASP3 Kits ELISA) activity.
the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (Montrer BBC3 Kits ELISA) transcription in response to ER stress.
Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)
DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)
rps19 (Montrer RPS19 Kits ELISA)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (Montrer TP53 Kits ELISA) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia
Overexpression of DeltaNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with Atopic dermatitis and IL-31 (Montrer IL31 Kits ELISA) and IL-33 (Montrer IL33 Kits ELISA) are key players in the signaling pathways.
cells expressing both p63 (Montrer CKAP4 Kits ELISA) and p73 (Montrer ARHGAP24 Kits ELISA) exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.
Data suggest that this the selective targeting of genes by tumor suppressor protein (Montrer TP53 Kits ELISA) p63 (p63 (Montrer CKAP4 Kits ELISA)) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends.
p63alpha protein up-regulates heat shock protein 70 (Montrer HSP70 Kits ELISA) expression via E2F1 transcription factor (Montrer E2F1 Kits ELISA) 1 (Montrer HNF1A Kits ELISA), promoting Wasf3/Wave3 (Montrer WASF3 Kits ELISA)/MMP9 (Montrer MMP9 Kits ELISA) signaling and bladder cancer invasion
these results therefore highlight an unanticipated role for p53 (Montrer TP53 Kits ELISA) family proteins in a regulatory network that integrates essential Wnt (Montrer WNT2 Kits ELISA)-Tcf (Montrer HNF4A Kits ELISA) and nodal-Smad (Montrer SMAD1 Kits ELISA) inputs.
the double mutant spermatocytes apoptosed at late pachynema because of sex body deficiency; thus p53 (Montrer TP53 Kits ELISA) and TAp63 are dispensable for arrest caused by sex body defects. These data affirm that recombination-dependent and sex body-deficient arrests occur via genetically separable mechanisms.
TGFb3 (Montrer TGFB3 Kits ELISA)-induced down-regulation of p63 (Montrer CKAP4 Kits ELISA) in the medial edge epithelia of the palatal shelves is a pre-requisite for palatal fusion by facilitating periderm migration from, and reducing the proliferative potential of, the midline epithelial seam thereby preventing cleft palate.
miR-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression.
Taken together, these data show that p63 (Montrer CKAP4 Kits ELISA) regulates the self-renewal and differentiation of oesophageal stem cells in humans and mice.
IL-6 (Montrer IL6 Kits ELISA)/P-STAT3 (Montrer STAT3 Kits ELISA) activation influences p63 (Montrer CKAP4 Kits ELISA) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (Montrer BMP4 Kits ELISA).
The role of p63 as a negative Wnt (Montrer WNT2 Kits ELISA)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, tumor protein p63
, transformation related protein 63
, tumor protein 63 kDa
, tumor protein 63-like