anti-U2AF Homology Motif (UHM) Kinase 1 (UHMK1) Anticorps

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. De plus, nous expédions U2AF Homology Motif (UHM) Kinase 1 Protéines (8) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
UHMK1 127933 Q8TAS1
UHMK1 16589 P97343
UHMK1 246332 Q63285
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Top anti-U2AF Homology Motif (UHM) Kinase 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 95 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of anti-KIS Pab (ABIN392641) in mouse heart tissue lysate. KIS (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-Uhmk1 Antibody   Titration: 1.0 ug/ml   Positive Control: Mouse Heart 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Chèvre Inconjugué ELISA   100 μg Connectez-vous pour afficher 6 to 7 Days
$291.53
Détails
Humain Souris Inconjugué FACS, WB 100 μL Connectez-vous pour afficher 11 to 14 Days
$522.50
Détails
Chien Souris Inconjugué WB 100 μL Connectez-vous pour afficher 11 to 14 Days
$522.50
Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Souris Lapin Inconjugué WB Mouse Uhmk1 Antibody (N-term)  western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Uhmk1 antibody detected the Uhmk1 protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué WB Western Blot at 1:1000 dilution Lane 1: human skeletal muscle lysate Lane 2: A-673 whole cell lysate Lysates/proteins at 20 ug per lane. Antibody is used in Western blot to detect KIST in K562 cell lysate (Lane 1) and mouse liver tissue lysate (Lane 2). 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Humain Chèvre Inconjugué ELISA, WB   0.1 mg Connectez-vous pour afficher 2 to 3 Days
$446.88
Détails

anti-U2AF Homology Motif (UHM) Kinase 1 Anticorps mieux référencés

  1. Human Polyclonal UHMK1 Primary Antibody pour IHC (p), WB - ABIN392641 : Bièche, Manceau, Curmi, Laurendeau, Lachkar, Leroy, Vidaud, Sobel, Maucuer: Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human. dans Brain research. Molecular brain research 2003 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal UHMK1 Primary Antibody pour IHC (p), ELISA - ABIN544233 : Petrovic, Costa, Lau, Raychaudhuri, Tyner: FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression. dans The Journal of biological chemistry 2007 (PubMed)

  3. Cow (Bovine) Polyclonal UHMK1 Primary Antibody pour ELISA - ABIN4228447 : Nakamura, Okinaka, Hirano, Ono, Sugimoto, Shigeno, Fujisawa, Shinjo, Ohnishi: KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells. dans Leukemia research 2008 (PubMed)

Plus d’anticorps contre U2AF Homology Motif (UHM) Kinase 1 partenaires d’interaction

Human U2AF Homology Motif (UHM) Kinase 1 (UHMK1) interaction partners

  1. UHMK1 plays a role in hematopoietic cell differentiation and suppression of autonomous clonal growth of leukemia cells.

  2. genome-wide association study identified the UHMK1 gene as a novel bone mineral density locus specific to East Asians.

  3. Moreover, we showed that CATS and KIS antagonize the transactivation capacity of CALM/AF10.In summary, our results show that CATS interacts with and is a substrate for KIS, suggesting that KIS regulates CATS function

  4. The contribution of UHMK1 gene in schizophrenia susceptibility, was explored.

  5. We identify the kinase responsible for S10 phosphorylation as human kinase interacting stathmin (hKIS) and show that it regulates cell cycle progression in response to mitogens.

  6. KIS gene was overexpressed in NF1-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) as compared to dermal neurofibroma which suggests a possible implication of KIS in the genesis of NF1-associated tumors.

  7. Evidence indicating that UHMK1 may be a candidate susceptibility gene for Schizophrenia in the British population. UHMK1 is situated between previously implicated genes RGS4 and NOS1AP.

  8. KIS promoter is activated by serum-responsive GABP binding to Ets-binding sites which leads to KIS gene expression, cell migration, and cell cycle progression

  9. Results show that KIS is a direct transcriptional target of FoxM1.

  10. Overexpression of KIS protein kinase is associated with acute myelogenous leukemia, myelodysplastic syndrome and acute lymphoblastic leukemia

  11. A follow up article showing further association between markers in UHMK1 and schizophrenia in a London based sample. Association replicated in an independent Scottish sample.

  12. KIS is expressed in neurons, and its encoded protein is localised to the nucleus and cytoplasm. No difference in KIS expression was found between schizophrenics and controls or in the lymphoblast cell lines.

Mouse (Murine) U2AF Homology Motif (UHM) Kinase 1 (UHMK1) interaction partners

  1. The absence of KIS results in a significant decrease in AMPA receptors in dendritic spines.

  2. disregulation of gene expression due to KIS inactivation affects specific brain functions.

  3. Uhmk1 was concentrated in the nucleus, but cycled rapidly between nucleus and cytosol.

  4. Endogenous mouse KIS was detected mainly in the nucleus of asynchronously growing cells. During serum starvation, its expression was reduced.

  5. KIS is a component of the molecular device that modulates translation in RNA-transporting granules as a result of local signals.

  6. Phosphorylation of p27Kip1 by KIS leads to cell-cycle progression, whereas the target sequence and the physiological relevance of KIS-mediated stathmin phosphorylation in VSMCs

U2AF Homology Motif (UHM) Kinase 1 (UHMK1) profil antigène

Profil protéine

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with UHMK1

  • U2AF homology motif kinase 1 (UHMK1) anticorps
  • U2AF homology motif (UHM) kinase 1 (uhmk1) anticorps
  • U2AF homology motif (UHM) kinase 1 (UHMK1) anticorps
  • U2AF homology motif (UHM) kinase 1 (Uhmk1) anticorps
  • U2AF homology motif kinase 1 (Uhmk1) anticorps
  • 4732477C12Rik anticorps
  • 4930500M09Rik anticorps
  • AA673513 anticorps
  • AI449218 anticorps
  • AU021979 anticorps
  • KIS anticorps
  • Kist anticorps
  • P-CIP2 anticorps
  • UHMK1 anticorps
  • zgc:153241 anticorps

Protein level used designations for UHMK1

U2AF homology motif (UHM) kinase 1 , kinase interacting stathmin , serine/threonine-protein kinase Kist , serine/threonine-protein kinase Kist-like , KIS protein kinase , PAM COOH-terminal interactor protein 2 , kinase interacting with leukemia-associated gene (stathmin) , U2AF homology motif kinase 1 , kinase interacting with stathmin , P-CIP2

GENE ID SPECIES
424369 Gallus gallus
469560 Pan troglodytes
720105 Macaca mulatta
767721 Danio rerio
100058796 Equus caballus
100408720 Callithrix jacchus
100585553 Nomascus leucogenys
100622137 Sus scrofa
127933 Homo sapiens
16589 Mus musculus
478986 Canis lupus familiaris
246332 Rattus norvegicus
538770 Bos taurus
100172072 Pongo abelii
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