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Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. De plus, nous expédions USP11 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal USP11 Primary Antibody pour WB - ABIN1944797
Ideguchi, Ueda, Tanaka, Yang, Tsuji, Ohno, Hagiwara, Aoki, Ishigatsubo: Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. dans The Biochemical journal 2002
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show that USP11 is associated with the mitotic spindle, does not regulate SAC (Montrer ADCY10 Anticorps) inactivation, but controls ubiquitination of RAE1 (Montrer RAE1 Anticorps) at the mitotic spindle, hereby functionally modulating its interaction with Nuclear Mitotic Apparatus protein (NuMA (Montrer NUMA1 Anticorps))
High USP11 expression is associated with cancer.
USP11 may contribute to the pathogenesis of pulmonary fibrosis by stabilization of TbetaRII and promotion of TGFbeta (Montrer TGFB1 Anticorps)-1 signaling.
We demonstrated that, while depletion of XIAP (Montrer XIAP Anticorps) attenuates cell transformation, elevated USP11 significantly promotes the tumor colony formation through stabilization of XIAP (Montrer XIAP Anticorps).
These findings elucidate deeply and extensively the mechanism of RNF8 (Montrer RNF8 Anticorps)/RNF168 (Montrer RNF168 Anticorps) and USP11 to maintain the proper status of ubiquitylation gammaH2AX (Montrer H2AFX Anticorps) to repair double strand breaks.
novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 and RNF4 (Montrer RNF4 Anticorps) as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR (Montrer DDR1 Anticorps).
PML (Montrer PML Anticorps) degradation mechanism through Notch (Montrer NOTCH1 Anticorps)/Hey1 (Montrer HEY1 Anticorps)-induced repression of USP11 involved in brain tumour pathogenesis
USP11 is a novel regulator of p53 (Montrer TP53 Anticorps), which is required for p53 (Montrer TP53 Anticorps) activation in response to DNA damage
Our data support a model whereby USP11 domains outside the catalytic core domain serve as protein interaction or trafficking modules rather than a direct regulatory function of the proteolytic activity.
USP-11 is not a predictor of a pCR after anthracycline-taxane-containing NST (Montrer SULT4A1 Anticorps) for breast cancer. Low USP-11 expression was independently correlated with better survival outcomes.
USP11 augments TGFbeta (Montrer TGFB1 Anticorps) signalling by deubiquitylating ALK5 (Montrer TGFBR1 Anticorps).
structural and functional characterization of the USP11 deubiquitinating enzyme
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23
ubiquitin carboxyl-terminal hydrolase 11
, ubiquitin specific protease 11
, ubiquitin specific peptidase 11
, universal stress protein
, deubiquitinating enzyme 11
, ubiquitin carboxyl-terminal hydrolase, X-linked
, ubiquitin thioesterase 11
, ubiquitin thiolesterase 11
, ubiquitin-specific processing protease 11
, ubiquitin-specific-processing protease 11