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Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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None of the genitourinary pseudosarcomatous myofibroblastic proliferations was found to harbour USP6 (0/12), ROS1 (Montrer ROS1 Anticorps) (0/8) or ETV6 (Montrer ETV6 Anticorps) (0/7) rearrangements
we identified seven novel fusion partners for USP6 in nodular fasciitis, highlighting the importance of USP6 expression and promoter-swapping fusions in the etiology of this neoplasm
Report the presence of USP6 rearrangements in a subset of cellular fibroma of tendon sheath.
our studies highlight Jak1 (Montrer JAK1 Anticorps) as the first identified substrate for USP6, and they offer a mechanistic rationale for the clinical investigation of Jak (Montrer JAK3 Anticorps) and STAT3 (Montrer STAT3 Anticorps) inhibitors as therapeutics for the treatment of bone and soft tissue tumors along with other neoplasms driven by USP6 overexpression
Molecular analyses revealed the presence and amplification of the novel PPPR6-USP6 gene fusion, which resulted in USP6 mRNA transcriptional upregulation. These findings further support the oncogenic role of the USP6 protease in mesenchymal neoplasia and expand the biologic potential of Nodular fasciitis
It was shown that TRE17 activates the classical NF-kappa B (Montrer NFKB1 Anticorps) pathway through an atypical mechanism that does not involve IkappaB degradation. Optimal activation of NF-kappa B (Montrer NFKB1 Anticorps) by TRE17 required both catalytic subunits of IkappaB kinase (Montrer CHUK Anticorps).
USP6 fluorescence in-situ hybridization is a useful ancillary test in cases where nodular fasciitis is a potential diagnostic consideration.
the deubiquitylase ubiquitin-specific protease 6 (USP6) as a potent activator of Wnt (Montrer WNT2 Anticorps) signaling. USP6 enhances Wnt (Montrer WNT2 Anticorps) signaling by deubiquitylating Fzds, thereby increasing their cell-surface abundance.
TRE17/USP6 regulates ubiquitylation and trafficking of cargo proteins that enter cells by clathrin-independent endocytosis
8 of the 9 giant cell reparative granulomas from hands and feet showed rearrangements of the USP6 gene compared with none of 8 gnathic lesions
Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
TBC1D3 and USP32 fusion
, deubiquitinating enzyme 6
, hyperpolymorphic gene 1
, proto-oncogene TRE-2
, tre-2 oncogene
, ubiquitin carboxyl-terminal hydrolase 6
, ubiquitin specific peptidase 6-
, ubiquitin specific protease 6 (Tre-2 oncogene)
, ubiquitin thioesterase 6
, ubiquitin thiolesterase 6
, ubiquitin-specific protease USP6
, ubiquitin-specific-processing protease 6