Ubiquitin Specific Peptidase 8 (USP8) Kits ELISA

Human Ubiquitin Specific Peptidase 8 (USP8) interaction partners

1. the EGFR (Montrer EGFR Kits ELISA)-USP8-trichoplein-Aurora A (Montrer AURKA Kits ELISA) axis is a critical signaling cascade that restricts ciliogenesis in dividing cells, and functions to facilitate cell proliferation

2. in human cells, Usp8 knockdown increased the lysosomal degradation of alpha-synuclein.

3. Overexpression of USP8 in lung adenocarcinoma is an early event during the course of tumor progression, and is related to EGFR (Montrer EGFR Kits ELISA) expression.

4. Somatic mutations in USP8 are common in Nelson's tumors, and are associated with less favorable outcome after surgery.

5. Data indicate that USP8 functions as a novel deubiquitylase of FLIPL and inhibits extrinsic apoptosis by stabilizing FLIPL.

6. Somatic USP8 gene mutations are a common cause of pediatric Cushing disease due to pituitary adenoma.

7. findings demonstrate that USP8 plays a key role in the trafficking and degradation of BACE1 (Montrer BACE Kits ELISA) by deubiquitinating lysine 501.

8. USP8 regulates VEGFR2 (Montrer KDR Kits ELISA) trafficking, signaling and proteolysis.

9. Ubpy loss of function results in the accumulation of autophagosomes due to a blockade of the autophagy flux.

10. Results show that in addition to the scaffolding function in complex formation, BRUCE has an E3 ligase function to promote BRIT1 deubiquitination by USP8 leading to accumulation of BRIT1 at DNA double-strand break.

Mouse (Murine) Ubiquitin Specific Peptidase 8 (USP8) interaction partners

1. the membrane receptor MET, described herein for the first time in spermatids, is a USP8/UBPy-target substrate is delivered to the acrosome.

2. in neuronal cells USP8 could be involved in endosomal trafficking, retrograde transport and synaptic plasticity. In disorders leading to neurodegeneration USP8 is upregulated and could influence the neuron-oligodendrocyte interactions.

3. The spatio-temporal expression of mUBPy suggests that the enzyme may be involved in neuroregulatory processes during embryogenesis.

4. a role for the USP8.STAM complex as a protective mechanism regulating early endosomal sorting of EGFR (Montrer EGFR Kits ELISA) between pathways destined for lysosomal degradation and recycling.

5. USP8 was able to interact with spermatid endosomal-sorting complex required for transport-0 and microtubule structures; USP8 can directly link, via its MIT domain, the labeled vesicles/developing acrosome to microtubules.

6. in wobbler testis expression of mouse ubiquitin-specific processing protease (mUBPy)is up-regulated, while a differential sorting of the protein characterizes wobbler spermatids where acrosome formation is impaired

7. Data indicate a novel mechanism where diacylglycerol kinase delta (Montrer DGKD Kits ELISA) and protein kinase (Montrer CDK7 Kits ELISA) Calpha (Montrer PRKACA Kits ELISA) modulate the levels of ubiquitinated epidermal growth factor (Montrer EGF Kits ELISA) receptors through Akt (Montrer AKT1 Kits ELISA) and ubiquitin-specific protease 8.

8. deubiquitinating enzyme specifically expressed in testis, associates with the acrosome and centrosome in mouse germ cells

9. Results indicate that Nrdp1 is a specific target for the USP8 deubiquitinating enzyme and are consistent with a model where USP8 augments Nrdp1 activity by mediating its stabilization.

10. We conclude that UBPY negatively regulates the rate of EGFR (Montrer EGFR Kits ELISA) down-regulation by deubiquitinating EGFR (Montrer EGFR Kits ELISA) on endosomes.