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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. De plus, nous expédions Ubiquitin-Conjugating Enzyme E2A Kits (15) et Ubiquitin-Conjugating Enzyme E2A Protéines (13) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal ube2a Primary Antibody pour ICC, IF - ABIN151985
Dul, Walworth: The plant homeodomain fingers of fission yeast Msc1 exhibit E3 ubiquitin ligase activity. dans The Journal of biological chemistry 2007
Show all 2 Pubmed References
RAD6 is upregulated in response to chemotherapy and significantly correlated with expression of ovarian cancer (OC) stem cell signaling genes ALDH1A1 (Montrer ALDH1A1 Anticorps) and SOX2 (Montrer SOX2 Anticorps) and poor prognosis of OC patients.
RAD6 promotes proteasome activity and nuclear translocation by enhancing the degradation of PSMF1 (Montrer PSMF1 Anticorps) and the lamin B receptor (Montrer LBR Anticorps).
Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.
Results showed KCMF1 (Montrer KCMF1 Anticorps) C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 (Montrer UBR4 Anticorps) and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 (Montrer KCMF1 Anticorps) and UBR4 (Montrer UBR4 Anticorps).
This study investigates clinical and molecular data of two unrelated, affected males with chromosome Xq24 deletions encompassing UBE2A.
RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha (Montrer CBX5 Anticorps) at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway
HHR6 and hRad18 (Montrer RAD18 Anticorps) can monoubiquitinate FANCD2 (Montrer FANCD2 Anticorps) at lysine 561 in vitro. This activity may represent a novel stress response pathway.
RNF168 (Montrer RNF168 Anticorps), in complex with RAD6A or RAD6B (Montrer UBE2B Anticorps), is activated in the DNA-damage-induced protein ubiquitination cascade.
RAD6A is a regulator of Parkin (Montrer PARK2 Anticorps)-dependent mitophagy plays a critical role in maintaining neuronal function.
UBE2A specifically interacts with CDK9 (Montrer CDK9 Anticorps), but not CDK2 (Montrer CDK2 Anticorps) and is phosphorylated by CDK9 (Montrer CDK9 Anticorps) in vitro.
results indicate a causal role of UBE2A in learning and mGLUR (Montrer GRM8 Anticorps)-dependent long-term depression
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A (Montrer TCF3 Anticorps)-deficient mice.
signaling through Notch (Montrer NOTCH1 Anticorps) modulates the turnover of E2A (Montrer TCF3 Anticorps) proteins
absence of mHR6A in oocytes prevents development beyond the embryonic two-cell stage
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
ubiquitin-conjugating enzyme E2 A
, ubiquitin-conjugating enzyme E2A (RAD6 homolog)
, ubiquitin-conjugating enzyme E2A
, RAD6 homolog A
, ubiquitin carrier protein A
, ubiquitin-protein ligase A
, ubiquitin-conjugating enzyme E2A, RAD6 homolog
, ubiquitin-conjugating enzyme HR6A