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ETS1 encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. De plus, nous expédions V-Ets erythroblastosis Virus E26 Oncogene Homolog 1 (Avian) Anticorps (228) et V-Ets erythroblastosis Virus E26 Oncogene Homolog 1 (Avian) Kits (14) et beaucoup plus de produits pour cette protéine.
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High ETS1 expression is associated with cervical cancer.
Ets-1 is induced by BRAF (Montrer BRAF Protéines) or MEK (Montrer MAP2K1 Protéines) kinase inhibition, resulting in increased NRAS (Montrer NRAS Protéines) expression, which could be blocked by inactivation of Usp9x (Montrer USP9X Protéines).
demonstrated that the interaction of Ets-1 with DNA-PK was mediated through the Ku70 (Montrer XRCC6 Protéines) subunit and was mapped to the C-terminal region of Ets-1 and the C-terminal part of Ku70 (Montrer XRCC6 Protéines) including SAP (Montrer APCS Protéines) domain
Results show thatproto-Oncogene Protein ets-1 (ETS1) drives ovarian cancer (OC) metastasis phenotypes through its transcriptional target PTK2 (focal adhesion kinase FAK).
High ETS-1 expression is associated with Colorectal Cancer.
Results showed that apo(a (Montrer APOA Protéines)) and Ets1 were differentially expressed in SMMC7721 and HepG2 cell lines. Meanwhile, apo(a (Montrer APOA Protéines)) and Ets1 were inversely correlated with several hepatic endogenous miRNAs, such as miR (Montrer MLXIP Protéines)-125b-5p, miR (Montrer MLXIP Protéines)-23b-3p, miR (Montrer MLXIP Protéines)-26a-5p, and miR (Montrer MLXIP Protéines)-423-5p, which were predicted to bind to Ets1.
depending on the microenvironment conditions and endogenous miR (Montrer MLXIP Protéines)-125b levels, bone-metastatic cells might switch from Ets-1-dependent motility towards colonization/growth, regulated by the balance between Ets-1 and HIF-1 (Montrer HIF1A Protéines).
ETS1 polymorphism was suggested to be associated with granulomatosis with polyangiitis and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a Japanese population.
Results indicated that miR (Montrer MLXIP Protéines)-193a-3p suppressed gastric growth and motility, at least partly, by directly targeting cyclin D1 (CCND1 (Montrer CCND1 Protéines)) and ETS proto-oncogene (Montrer RAB1A Protéines) 1 (ETS1) expression.
Data indicate that in glioblastoma, ETS proto-oncogene (Montrer RAB1A Protéines) 1 (ETS-1)-expression is not dependent on hypoxia, but correlates with tumor vascularization.
miR (Montrer MLXIP Protéines)-326 may target the Ets-1 protein to contribute to iodide-induced thyroiditis, providing a new theoretical basis for the use of miRNA targeting therapy for the treatment of autoimmune diseases.
endothelial master transcription factor ETS1 promotes global RNAPII pause release, and that this process is governed by VEGF (Montrer VEGFA Protéines)
results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center
Dynamically and epigenetically coordinated GATA2 (Montrer GATA2 Protéines)/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation.
data reveal ETS1 as a critical regulator of ILC2 expansion and cytokine production and implicate ETS1 in the regulation of Id2 at the inception of ILC2 development.
Ets1 predominantly binds distal nucleosome-occupied regions in double negative thymocytes and nucleosome-depleted regions in double positive thymocytes. importantly, Ets1 induces chromatin remodeling by displacing H3K4me1-marked nucleosomes.
reduced lung levels of PPARgamma (Montrer PPARG Protéines) and increased levels of microRNA-27a (miR (Montrer MLXIP Protéines)-27a), v-ets avian erythroblastosis virus E26 oncogene (Montrer RAB1A Protéines) homolog 1 (ETS1), endothelin-1 (ET-1 (Montrer EDN1 Protéines)), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 (Montrer PECAM1 Protéines) and E selectin (Montrer SELE Protéines)).
the affinities of two sequence-divergent ETS homologs, PU.1 and Ets-1, to DNA sites harboring a hemi- and fully methylated CpG dinucleotide, were measured.
data support a general model in which Ets-1 interacts with nonspecific DNA via dynamic electrostatic interactions, whereas hydrogen bonding drives the formation of well-ordered complexes with specific DNA
Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 (Montrer PDX1 Protéines) expression in type 2 diabetes.
The activity of Gata4 (Montrer GATA4 Protéines) cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS sites.
Ets-1 up-regulation is involved in the development of retinal neovascularization.
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1
, ets protein
, protein C-ets-1
, v-ets avian erythroblastosis virus E2 oncogene homolog 1
, TNFAIP3 interacting protein 1
, c-ets-1 oncogene
, p54 transcription factor
, transforming protein p54/c-ets-1
, transforming protein p68/c-ets-1
, virion-associated nuclear-shuttling protein
, Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1)
, v-ets erythroblastosis virus E26 oncogene homolog 1
, v-ets erythroblastosis virus E26 oncogene-like protein 1
, Ets protein
, v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
, C-ets-1 protein (p54)
, avian erythroblastosis virus E26 oncogene 1
, tumor progression locus 1
, protein c-ets-1-B