V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) Protéines (MAF)

The protein encoded by MAF is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. De plus, nous expédions V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) Anticorps (113) et V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) Kits (18) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MAF 17132 P54843
MAF 4094 O75444
MAF 54267 P54844
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Top V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) Protéines sur anticorps-enligne.fr

Showing 9 out of 9 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails
Levure Poisson Zèbre His tag   1 mg 60 to 71 Days
$2,880.17
Détails
Levure Xenopus tropicalis His tag   1 mg 60 to 71 Days
$2,959.00
Détails
Levure Poulet His tag   1 mg 60 to 71 Days
$2,979.17
Détails
Levure Rat His tag   1 mg 60 to 71 Days
$3,010.33
Détails
Levure Boeuf (Vache) His tag   1 mg 60 to 71 Days
$3,036.00
Détails
Escherichia coli (E. coli) Humain Inconjugué   1 mg 11 to 18 Days
$1,762.47
Détails

MAF Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human ,
,
Rat (Rattus)

Plus protéines pour V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) partenaires d'interaction

Mouse (Murine) V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) interaction partners

  1. Results show that the SUMOylation status of c-Maf has a stronger regulatory effect on IL-21 than the level of c-Maf expression, through an epigenetic mechanism. These findings provide new insights into how SUMOylation modulates the pathogenesis of autoimmune diabetes in a T cell-restricted manner and on the basis of a single transcription factor.

  2. this study shows that macrophages switch their phenotype by regulating Maf expression during different phases of inflammation

  3. this study shows that c-Maf is essential for the commitment of IL-17-producing gammadelta T cells

  4. Bivariate genomic footprinting elucidated the c-Maf transcription-factor network...and led to the identification and validation of c-Maf as a negative regulator of IL-2.

  5. c-Maf acts to preserve the identity and function of intestinal Treg cells, which is essential for the establishment of host-microbe symbiosis.

  6. these data demonstrate that c-Maf is an indispensable yet constitutive transcription factor for IL-10 gene expression in LPS-activated B cells

  7. The control of cMaf expression at the translational level by mTOR regulated the expression of inflammatory genes in response to lipopolysaccharide challenge.

  8. results suggest that pathobiont-dependent inflammatory bowel disease is driven by microbiota-reactive T cells that have escaped this c-MAF-dependent mechanism of iTreg-TH17 homeostasis

  9. c-Maf is a critical transcription factor regulating T-cell specialization in mice, essential for generation of both RORgammat(+) Tregs and T follicular regulatory cells, but not for adipose-resident Tregs. c-Maf is induced in Tregs by IL-6 and TGF-beta.

  10. interplay between MATalpha1, c-Myc, and Maf proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis

  11. MafB and c-Maf have different expression patterns in macrophages, suggesting differences in function.

  12. HERC4 mediates c-Maf ubiquitination and delays growth of multiple myeloma.

  13. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf.

  14. Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity.

  15. endogenous small-Maf factors negatively regulate beta-cell function by competing for MafA binding, and thus, the inhibition of small-Maf activity can improve beta-cell function

  16. The melanoma microenvironment contributes to skewing of CD8 T cell differentiation programs, in part by TGFbeta/IL-6-mediated induction of Maf.

  17. Sox5 physically associates with c-Maf via the HMG domain of Sox5 and DNA-binding domain of c-Maf, and Sox5 together with c-Maf directly activates the promoter of RORgammat in CD4(+) T cells.

  18. KLF13 directly binds to IL-4 promoter regions and synergizes with c-Maf to positively regulate IL-4 expression.

  19. The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf.

  20. Translocations between IGH and MAF may arise only in the absence of close proximity to the more frequent partners in multiple myeloma.

Human V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) interaction partners

  1. CCND1, NSD2, and MAF gene rearrangements were estimated accurately by IHC, suggesting that conventional FISH assays can be replaced by IHC.

  2. Our results identify c-MAF as a relevant factor that drives two highly divergent post-activation fates of human TH17 cells

  3. A novel MAF mutation was identified in a Chinese family with congenital non-syndromic bilateral nuclear cataracts.This novelp.Val271Glu mutation impairs the transcriptional activity of crystallins by MAF.

  4. This study highlights that TMEPAI decreases c-Maf stability by recruiting the ubiquitin ligase NEDD4 to c-Maf for proteasomal degradation in myeloma cells.

  5. MAF overexpression contributes to PMF pathogenesis.

  6. common variant , rs889472, of c-MAF is associated with gout susceptibility.

  7. we identified two heterozygous rare variants in genes that are involved in early cataract development; the novel c.809C>A; p.(Ser270Tyr) in MAF and the c.168C>G; p.(Tyr56 *) variant in CRYGD, previously reported as pathogenic

  8. UBE2O mediates c-Maf polyubiquitination and degradation, induces MM cell apoptosis, and suppresses myeloma tumor growth, which provides a novel insight in understanding myelomagenesis and UBE2O biology.

  9. The interaction between c-Maf and RORgammat, and Blimp-1.

  10. Polymorphisms rs9939609 (FTO gene) and rs1424233 (MAF gene) were genotyped using allelic discrimination assays in a prospective multicenter cohort study; these polymorphisms did not show associations with birth weight, BMI and Ponderal Index at discharge, and weight gain, neither testing for a dominant, additive nor for a recessive model.

  11. this study shows that genes associated with MAF-binding enhancers are suppressed in macrophages isolated from rheumatoid-arthritis patients, revealing a disease-associated signature of IFN-gamma-mediated repression

  12. Our results argued that increased expression of sIL6R from myeloid cells and subsequent c-Maf induction were adverse events for counteracting tumor-specific Th1 generation. Overall, this work provides a mechanistic rationale for sIL6R targeting to improve the efficacy of T-cell-mediated cancer immunotherapy

  13. These results define the role of MAF and GSK3 in the resistance of t(14;16) multiple myeloma to proteasome inhibitors.

  14. interplay between MATalpha1, c-Myc, and Maf proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis

  15. Epidermal differentiation gene regulatory networks are controlled by MAF and MAFB.

  16. Findings implicate the strong effects of ROS on multiple stem cell functions with a central role for c-Maf in stem cell senescence.

  17. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf.

  18. Data suggest miR-1290 as the new oncomiR involved in laryngeal squamous cell carcinoma pathogenesis probably through downregulation of its target genes MAF and ITPR2.

  19. Results suggest that MAF is a mediator of breast cancer bone metastasis. 16q23 gain or MAF protein overexpression in tumors may help to select patients at risk of bone relapse.

  20. Differential effect of cataract-associated mutations in MAF on transactivation of MAF target crystalline genes.

Profil protéine V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF)

Profil protéine

The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MAF

  • MAF bZIP transcription factor (MAF)
  • v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) (MAF)
  • avian musculoaponeurotic fibrosarcoma oncogene homolog (Maf)
  • MAF bZIP transcription factor (Maf)
  • v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a) (mafa)
  • 2810401A20Rik Protéine
  • A230108G15Rik Protéine
  • AW047063 Protéine
  • C-Maf Protéine
  • CCA4 Protéine
  • cMaf Protéine
  • DKFZp459D1731 Protéine
  • fl13d12 Protéine
  • MAF Protéine
  • Maf2 Protéine
  • wu:fl13d12 Protéine
  • Z-cmaf Protéine

Protein level used designations for MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) , V-maf musculoaponeurotic fibrosarcoma oncogene homolog , c-Maf long form , proto-oncogene c-maf , transcription factor Maf , Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene , T lymphocyte c-maf long form , c-maf proto-oncogene , proto-oncogene c-Maf , C-Maf , transcription factor Maf-2 , c-Maf , Proto-oncogene c-maf

GENE ID SPECIES
454260 Pan troglodytes
100294582 Pongo abelii
17132 Mus musculus
4094 Homo sapiens
54267 Rattus norvegicus
114467 Danio rerio
693248 Gallus gallus
782481 Bos taurus
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