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The protein encoded by MAFB is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. De plus, nous expédions MAFB Protéines (9) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal MAFB Primary Antibody pour ICC, IF - ABIN4332354
Pasquali, Gaulton, Rodríguez-Seguí, Mularoni, Miguel-Escalada, Akerman, Tena, Morán, Gómez-Marín, van de Bunt, Ponsa-Cobas, Castro, Nammo, Cebola, García-Hurtado, Maestro, Pattou, Piemonti, Berney et al.: Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. ... dans Nature genetics 2014
Show all 3 Pubmed References
Data suggest that SUMOylated MAFB promotes colorectal cancer tumorigenesis through cell cycle regulation.
these results demonstrate that MAFB critically determines the acquisition of the anti-inflammatory transcriptional and functional profiles of human macrophages
The present study demonstrated that miR (Montrer MLXIP Anticorps)-152 was downregulated in NPC (Montrer NPC1 Anticorps) tissues and cell lines. In addition, miR (Montrer MLXIP Anticorps)-152 expression and MAFB knockdown inhibited cell proliferation, migration and invasion, and miR (Montrer MLXIP Anticorps)-152 suppressed the expression of MAFB at the mRNA and protein levels.
Epidermal differentiation gene regulatory networks are controlled by MAF (Montrer MAF Anticorps) and MAFB.
Loss of MAFB Function Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects.
Results indicate a hepatocellular carcinoma (HCC (Montrer FAM126A Anticorps)) regulatory pathway involving MafB transcription factor and cyclin D1 (Montrer CCND1 Anticorps), the dysfunction of which drives proliferative character in HCC (Montrer FAM126A Anticorps).
DNMT3A (Montrer DNMT3A Anticorps) R882 mutation is associated with elevated expression of MAFB and M4/M5 immunophenotype of acute myeloid leukemia (Montrer BCL11A Anticorps) blasts.
MAFB is a regulator and a marker of adipose tissue inflammation, a process that subsequently causes insulin (Montrer INS Anticorps) resistance
MAFB represents a unique signature and likely important regulator of the primate islet beta-cell.
The rs2902940A allele carriers in the MAFB conferred a decreased serum ApoAI level in controls and an increased risk of coronary artery disease and ischemic stroke.
Vegfc (Montrer VEGFC Anticorps) signaling increases mafba expression to control downstream transcription
MAFB localized in Leydig and Sertoli cells in testes at E18.5 while it localized in Leydig cells, Sertoli cells, and pachytene spermatocytes in adult testes. Examination revealed that MAFB-deficient testes developed normally by E18.5, and spermatogenesis was not disrupted in adult mice. MAFB MAFB might be critical for phagocytosis activity of Sertoli cells.
MafB controls endothelial sprouting in vitro and in vivo in postnatal retinal angiogenesis.
Macrophage-specific inhibition of MafB may destabilize atherosclerotic plaques in advanced lesions
a protective role of oxLDL-associated LPS (Montrer TLR4 Anticorps) on beta-cell function during hyperlipidemia by inducing miR (Montrer MLXIP Anticorps)-155-5p, which prevents the upregulation of MafB and beta-to-alpha-cell reprogramming.
Increased mafB at the common myeloid progenitor stage steers their lineage away from the megakaryocyte erythrocyte progenitor production and drives the terminal fate of these progenitors to form macrophages vs. dendritic cells, causing anemia, monocytosis, and dendritic cell loss. It is a transcriptional activator of M-CSFR (Montrer CSF1R Anticorps) and a repressor of transferrin (Montrer Tf Anticorps) receptors, promoting macrophages and plasmacytoid dendritic cells.
An elevation of MSR1 (Montrer MSR1 Anticorps) levels in infiltrating myeloid cells observed 3 d after experimental stroke was dependent on the transcription factor Mafb. Mafb deficiency in infiltrating myeloid cells caused impaired clearance of DAMPs, more severe inflammation, and exacerbated neuronal injury in a murine model of ischemic stroke.
a Mafb-driven Cre strain was generated to determine whether any dendritic cells (DCs) identified by Zbtb46 (Montrer ZNF340 Anticorps)-green fluorescent protein expression originate from a Mafb-expressing population.
MafB deletion in maternal beta-cells also produced GDM, with inadequate beta-cell expansion accompanied by failure to induce PRLR (Montrer PRLR Anticorps)-dependent target genes regulating beta-cell proliferation. These results unveil molecular roles for PRLR (Montrer PRLR Anticorps) signaling in orchestrating the physiologic expansion of maternal beta-cells during pregnancy.
MafB play an important role in promoting hindbrain choroid plexus development during embryogenesis
Meanwhile, the observed reduction in the phagocytic activity of the MafB-shRNA-expressing cells was attenuated by ectopic expression of Fcgr3. Together, the results presented here indicate that MafB influences the phagocytic activity of macrophages by promoting Fcgr3, but not Fcgr2b, expression.
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns.
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
, v-maf musculoaponeurotic fibrosarcoma oncogene protein B
, v-maf musculoaponeurotic fibrosarcoma oncogene homolog B
, Transcription factor MafB
, bzip transcription factor mafB
, transcription factor MafB
, Kreisler maf-related leucine zipper homolog
, MAFB/Kreisler basic region/leucine zipper transcription factor
, Kreisler maf-related leucine zipper homolog (b-maf)
, transcription factor Maf-1
, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B
, transcription factor Val
, Kreisler (maf-related) leucine zipper protein
, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
, segmentation protein Kr