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VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. De plus, nous expédions Vaccinia Related Kinase 1 Protéines (16) et Vaccinia Related Kinase 1 Kits (9) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal VRK1 Primary Antibody pour ICC, IF - ABIN4365869
Sanz-García, Monsalve, Sevilla, Lazo: Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage. dans The Journal of biological chemistry 2012
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Human Monoclonal VRK1 Primary Antibody pour WB - ABIN1882291
Barcia, López-Borges, Vega, Lazo: Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1. dans Archives of biochemistry and biophysics 2002
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vrk-1 has a role in early uterine development in Caenorhabditis elegans
By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans.
Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53 (Montrer TP53 Anticorps).
Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.
this study not only provides a resource for investigating the unidentified functions of VRK1/VRK3, but also an insight into the regulatory roles of VRK1/VRK3 in biological processes.
Block the activation of the VRK1 promoter by Sox2 (Montrer SOX2 Anticorps).
VRK1 and BANF1 (Montrer BANF1 Anticorps) yielded AUCs of 0.790 and 0.735, respectively.
VRK1 AND VRK2 (Montrer VRK2 Anticorps) expression are predictive of tumor response to neoadjuvant chemoradiation therapy in rectal adenocarcinoma.
VRK1 was lowly expressed in adherent MM cells and highly expressed in suspended cells. In addition, VRK1 was positively correlated with the proliferation of MM cells by regulating the expression of cell cycle-related protein, such as cyclinD1, CDK2 (Montrer CDK2 Anticorps) and p27(kip1 (Montrer CDKN1B Anticorps)).
we conclude that VRK1 may be a candidate prognostic biomarker as well as a potential therapeutical target of hepatocellular carcinoma
VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC (Montrer FAM126A Anticorps).
VRK1 is a novel regulator of CBs (Montrer CBS Anticorps) dynamics and stability in cell cycle by protecting coilin (Montrer COIL Anticorps) from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.
VRK1 regulation of NBS1 (Montrer NBN Anticorps) contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.
VRK1 is a novel chromatin component that reacts to its alterations and participates very early in DNA damage response, functioning by itself or in cooperation with Ataxia Telangiectasia Mutated (Montrer ATM Anticorps) Proteins.
VRK1 self-represses its activity to phosphorylate PXR (Montrer NR1I2 Anticorps) through cyclin-dependent kinase 2 (CDK2 (Montrer CDK2 Anticorps)) in high glucose conditions, resulting in the repression of the PCK1 (Montrer PCK1 Anticorps) gene. This PXR (Montrer NR1I2 Anticorps) phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2 (Montrer CDK2 Anticorps)-PXR (Montrer NR1I2 Anticorps)-PP2Calpha (Montrer PPM1A Anticorps)-SGK2 (Montrer SGK2 Anticorps) pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.
VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (Montrer APP Anticorps)). APP (Montrer APP Anticorps) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (Montrer APP Anticorps)-dependent mechanism.
Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.
Protein kinase (Montrer CDK7 Anticorps) Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53 (Montrer TP53 Anticorps)-dependent manner.
reduction of VRK1 activity causes a delay in meiotic progression during oogenesis
VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance
Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.
These findings collectively support a role of VRK1 as a novel mitotic histone H3 (Montrer HIST3H3 Anticorps) kinase in mammals.
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
vaccinia related kinase 1
, serine/threonine-protein kinase VRK1
, serine/threonine-protein kinase VRK1-like
, vaccinia virus B1R-related kinase 1
, vaccinia-related kinase 1
, serine/threonine-protein kinase 51PK