anti-Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) (VPS13A) Anticorps

The protein encoded by VPS13A may control steps in the cycling of proteins through the trans-Golgi network to endosomes, lysosomes and the plasma membrane.

afficher tous les anticorps Gène GeneID UniProt
Anti-Rat VPS13A VPS13A 309243  
VPS13A 23230 Q96RL7
Anti-Souris VPS13A VPS13A 271564 Q5H8C4
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Top anti-Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) Anticorps sur anticorps-enligne.fr

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Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: Chorein Antibody [NBP1-85642] - Staining of human duodenum shows strong granular cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: Chorein Antibody [NBP1-85642] - Immunofluorescent staining of human cell line U-2 OS shows positivity in mitochondria. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$491.63
Détails
Humain Lapin Inconjugué IHC, IHC (p), IP Immunohistochemistry: Chorein Antibody [NBP1-85641] - Staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts. Immunohistochemistry-Paraffin: Chorein Antibody  - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$491.63
Détails
Humain Lapin Inconjugué IHC, WB   100 μL Connectez-vous pour afficher 7 to 9 Days
$551.83
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Humain Lapin Inconjugué EIA, IHC (fro), WB   0.2 mL Connectez-vous pour afficher 6 to 8 Days
$544.50
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Humain Lapin Inconjugué ELISA, IF, WB   100 μL Connectez-vous pour afficher 6 to 7 Days
$351.13
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Humain Lapin Inconjugué IHC (p)   100 μL Connectez-vous pour afficher 11 to 12 Days
$460.00
Détails

VPS13A Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité
Human , ,


anti-Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) Anticorps mieux référencés

  1. Human Polyclonal VPS13A Primary Antibody pour ICC, IF - ABIN4298102 : Morisaki, Yashiro, Kakehashi, Inagaki, Kinoshita, Fukuoka, Kasashima, Masuda, Sakurai, Kubo, Muguruma, Ohira, Wanibuchi, Hirakawa: Comparative proteomics analysis of gastric cancer stem cells. dans PLoS ONE 2014 (PubMed)

  2. Human Polyclonal VPS13A Primary Antibody pour IHC, IHC (p) - ABIN4298101 : Sasaki, Nakamura, Kodama, Urata, Shiokawa, Hayashi, Sano: Chorein interacts with α-tubulin and histone deacetylase 6, and overexpression preserves cell viability during nutrient deprivation in human embryonic kidney 293 cells. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 (PubMed)

Plus d’anticorps contre Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) partenaires d’interaction

Human Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) (VPS13A) interaction partners

  1. Expression of cancer-specific glycan epitopes represents an excellent opportunity for diagnostics and potentially specific detection of tumors. Here, we report four proteins (LIFR, CE350, VP13A, HPT) found in sera from pancreatic cancer patients carrying aberrant glycan structures as compared to those of controls.

  2. These results suggest that PI3P regulates the functioning of Vps13, both in protein trafficking and actin cytoskeleton organization. Attenuation of PI3P-binding ability in the mutant hVps13A protein may be one of the reasons for its mislocalization and disrupted function in cells of patients suffering from chorea-acanthocytosis .

  3. Chorein is a stimulator of Orai1 (Montrer ORAI1 Anticorps) expression and thus of store operated Ca2 (Montrer CA2 Anticorps)+ entry.

  4. Patients with chorea-acanthocytosis carrying a VPS13A mutation present with focal, treatment-resistant seizures.

  5. Defective chorein is accompanied by significant structural disorganization of all cytoskeletal structures.

  6. VPS13A-depleted cells showed accumulation of autophagic markers and impaired autophagic flux

  7. Chorein is expressed in various cancer cells. In cells with high chorein expression levels chorein silencing promotes apoptotic cell death, an effect paralleled by down-regulation of PI-3K activity and BCL-2 (Montrer BCL2 Anticorps)/Bax (Montrer BAX Anticorps) expression ratio.

  8. Discovery of new mutations may clarify the pathogenic roles of chorein in chorea-acanthocytosis as well as in the retina

  9. chorein interacts with beta-adducin (Montrer ADD2 Anticorps) and beta-actin (Montrer ACTB Anticorps).

  10. Data indicate functions of chorein, i.e., regulation of secretion and aggregation of blood platelets.

Mouse (Murine) Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) (VPS13A) interaction partners

  1. chorein interacts with beta-adducin (Montrer ADD2 Anticorps) and beta-actin (Montrer ACTB Anticorps).

  2. Mouse CHAC cDNA sequence and the exon-intron structures of the CHAC disease gene are identified and a CHAC model mouse produced by a gene-targeting technique.

  3. Brain-specific (Montrer CALY Anticorps) variants of VPS13A may be involved in the brain-specific (Montrer CALY Anticorps) pathology of chorea-acanthocytosis.

Vacuolar Protein Sorting 13 Homolog A (S. Cerevisiae) (VPS13A) profil antigène

Profil protéine

The protein encoded by this gene may control steps in the cycling of proteins through the trans-Golgi network to endosomes, lysosomes and the plasma membrane. Mutations in this gene cause the autosomal recessive disorder, chorea-acanthocytosis. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with VPS13A

  • vacuolar protein sorting 13 homolog A (Vps13a) anticorps
  • chorein (EHI_067970) anticorps
  • Chorein (GL50803_87358) anticorps
  • vacuolar protein sorting 13 homolog A (VPS13A) anticorps
  • vacuolar protein sorting 13A (Vps13a) anticorps
  • 4930425F11 anticorps
  • 4930516E05Rik anticorps
  • 4930543C13Rik anticorps
  • 9930023P20 anticorps
  • Chac anticorps
  • Chorein anticorps
  • D330038K10Rik anticorps
  • mKIAA0986 anticorps
  • RGD1311340 anticorps

Protein level used designations for VPS13A

vacuolar protein sorting 13 homolog A , chorein , vacuolar protein sorting 13A , Chorein , vacuolar protein sorting 13 homolog A (S. cerevisiae) , chorea-acanthocytosis protein , vacuolar protein sorting-associated protein 13A , chorea-acanthocytosis protein homolog , hypothetical protein

GENE ID SPECIES
309243 Rattus norvegicus
3411085 Entamoeba histolytica HM-1:IMSS
5700841 Giardia lamblia ATCC 50803
464538 Pan troglodytes
23230 Homo sapiens
271564 Mus musculus
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