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VDAC3 encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family.
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Cow (Bovine) Polyclonal VDAC3 Primary Antibody pour IHC, WB - ABIN2776182
Lefièvre, Chen, Conner, Scott, Publicover, Ford, Barratt: Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? dans Proteomics 2007
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Human Polyclonal VDAC3 Primary Antibody pour WB - ABIN4894329
Tanno, Kuno, Ishikawa, Miki, Kouzu, Yano, Murase, Tobisawa, Ogasawara, Horio, Miura: Translocation of glycogen synthase kinase-3β (GSK-3β), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2). dans The Journal of biological chemistry 2014
The AG genotype of rs16891278 showed a significantly lower sperm concentration compared with the AA genotype (P = 0.044). Findings suggest that VDAC3 genetic variants may be associated with human sperm count.
This cohort study showed that the VDAC3 gene was down regulation between patients with idiopathic Parkinson disease and controls
The works available on VDAC cysteines support the notion that VDAC1 (Montrer VDAC1 Anticorps), VDAC2 (Montrer VDAC2 Anticorps), and VDAC3 proteins are paralogs with a similar pore-function and slightly different, but important, ancillary biological functions. (Review)
VDAC3 is able to modulate its pore size and current by exploiting the mobility of the N-terminal and forming, upon external stimuli, disulfide bridges with cysteine residues located on the barrel and exposed to the inter-membrane space.
channel gating of VDAC3 might be controlled by redox sensing under physiological conditions
These data suggest that an interaction between Mcl-1 (Montrer MCL1 Anticorps) and VDAC promotes lung cancer cell migration by a mechanism that involves Ca(2 (Montrer CA2 Anticorps)+)-dependent reactive oxygen species production.
observed electrophysiological properties of hVDAC3 are surprisingly different from the other isoforms and are discussed in relation to the proposed physiological role of the protein in mammalian cells
a VDAC3-Mps1 (Montrer IDUA Anticorps) module at the centrosome promotes ciliary disassembly during cell cycle entry.
VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 (Montrer IDUA Anticorps) to centrosomes.
VDAC 1 (Montrer VDAC1 Anticorps), 2, and 3 recruit Parkin (Montrer PARK2 Anticorps) to defective mitochondria to promote mitochondrial autophagy.
Bcl-xL (Montrer BCL2L1 Anticorps) interacts functionally with VDAC1 (Montrer VDAC1 Anticorps) and -3 but not VDAC2 (Montrer VDAC2 Anticorps).
(n VDAC3 deficient mice the defect is restricted to the heart and only to complex IV.
Vdacs are dispensable for both MPT and Bcl-2 (Montrer BCL2 Anticorps) family member-driven cell death.
Bid (Montrer BID Anticorps) catalyzes MAC formation in isolated mitochondria containing Bax (Montrer BAX Anticorps) and/or Bak (Montrer BAK1 Anticorps) with a time course of minutes and does not require VDAC1 (Montrer VDAC1 Anticorps) or VDAC3.
VDAC2 (Montrer VDAC2 Anticorps) and VDAC3 might have an alternative structural organization and different functions in outer dense fibers (Montrer ODF1 Anticorps) than in mitochondria
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene.
outer mitochondrial membrane protein porin 3
, voltage-dependent anion-selective channel protein 3
, channel protein VDAC3
, mitochondrial outer membrane protein
, mitochondrial voltage dependent anion channel 3
, voltage-dependent anion channel 1 pseudogene 5
, voltage-dependent anion channel 5, pseudogene
, voltage-dependent anion channel 3