anti-Vpx Protein (VPX) Anticorps

Plays a role in nuclear translocation of the viral pre- integration complex (PIC), thus is required for the virus to infect non-dividing cells. De plus, nous expédions Vpx Protein Protéines (3) et beaucoup plus de produits pour cette protéine.

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Top anti-Vpx Protein Anticorps sur anticorps-enligne.fr

Showing 8 out of 12 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Virus Lapin Biotin ELISA   100 μg 11 to 16 Days
$469.05
Détails
Virus Lapin FITC ELISA   100 μg 11 to 16 Days
$469.05
Détails
Virus Lapin HRP ELISA   100 μg 11 to 16 Days
$469.05
Détails
Virus Lapin Inconjugué ELISA   100 μg 11 to 16 Days
$469.05
Détails
Virus Lapin Biotin ELISA   100 μg 11 to 16 Days
$469.05
Détails
Virus Lapin FITC ELISA   100 μg 11 to 16 Days
$469.05
Détails
Virus Lapin HRP ELISA   100 μg 11 to 16 Days
$469.05
Détails
Virus Lapin Inconjugué ELISA   100 μg 11 to 16 Days
$469.05
Détails

Plus d’anticorps contre Vpx Protein partenaires d’interaction

Simian Immunodeficiency Virus (SIV) Vpx Protein (VPX) interaction partners

  1. Data suggest that a critical role of vpx in vivo/in vitro is to promote degradation of SAMHD1 (SAM domain/HD domain protein 1) in memory CD4+ T-lymphocytes, thereby generating high levels of plasma viremia and induction of immunodeficiency.

  2. Vpr and Vpx share a highly similar DCAF1-binding motif, they interact with a different set of residues in DCAF1.

  3. SIV vpx is essential for macrophage infection but not for development of simian AIDS.

  4. Inhibition of deoxynucleotide hydrolysis by promoting SAMHD1 degradation is not the only mechanism by which Vpx rescues HIV-1 in mature monocyte-derived dendritic cells from the antiviral state.

  5. direct down-modulation of Vpx catalytic activity, mediated by the same binding event that leads to SAMHD1 recruitment to the E3 ubiquitin ligase for proteasome-dependent degradation

  6. The authors demonstrate that the Wx4Phix2Phix3APhixH motif in SIVmac Vpx is required for both the Vpx-DCAF1 interaction and/or Vpx-mediated degradation of SAMHD1.

  7. However, all the vpx mutant viruses were defective for replication in both human and pigtail monocyte-derived macrophages.

  8. Vpx induces proteasomal degradation of SAMHD1

  9. Vpx relieves the inhibition of lentivirus infection in macrophages by loading SAMHD1 onto the CRL4(DCAF1) E3 ubiquitin ligase, leading to highly efficient proteasome-dependent degradation of the protein

  10. This review describes the main functions ascribed to Vpr and Vpx in the context of both viral replication and modulation of host cell biology

  11. A single-point mutation in Vpx (H82A) abrogated binding to APOBEC3A and single-round infection of monocytes by HIV-1.

  12. Vpx is essential to overcome a block of early infection steps in primary monocytes

  13. host cell MAPK signal transduction pathway regulates an early step in SIV infection

  14. MacrophageS harbor a potent antiviral restriction; primate lentiviruses have evolved Vpx to counteract this restriction.

  15. when transferred in the context of a replication-competent viral clone, Vpx was required for replication in dendritic cells

Vpx Protein (VPX) profil antigène

Profil protéine

Plays a role in nuclear translocation of the viral pre- integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity). {ECO:0000250}.

Gene names and symbols associated with anti-Vpx Protein (VPX) Anticorps

  • vpx protein (vpx) anticorps

Protein level used designations for anti-Vpx Protein (VPX) Anticorps

Viral protein X , X ORF protein

GENE ID SPECIES
1490006 Simian immunodeficiency virus
Fournisseurs de qualité sélectionnés pour anti-Vpx Protein (VPX) Anticorps
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