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WDFY3 encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy.
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Human Polyclonal WDFY3 Primary Antibody pour EM, ICC - ABIN315857
Sommi, Necchi, Vitali, Montagna, De Luigi, Salmona, Ricci, Solcia: PaCS is a novel cytoplasmic structure containing functional proteasome and inducible by cytokines/trophic factors. dans PLoS ONE 2013
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Human Monoclonal WDFY3 Primary Antibody pour ELISA, WB - ABIN949075
Orosco, Ross, Cates, Scott, Wu, Sohn, Pleasure, Pleasure, Adamopoulos, Zarbalis: Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. dans Nature communications 2014
Cow (Bovine) Polyclonal WDFY3 Primary Antibody pour WB - ABIN2784358
Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... dans Nature 2005
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we demonstrate that normally ALFY attenuates the canonical Wnt (Montrer WNT2 Anticorps) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 (Montrer DVL3 Anticorps) and not of Dvl1 (Montrer DVL1 Anticorps) or Dvl2 (Montrer DVL2 Anticorps).
ALFY binds selectively to LC3C (Montrer MAP1LC3C Anticorps) and the GABARAPs through a LC3 (Montrer MAP1LC3A Anticorps)-interacting region in its WD40 domain (Montrer DCAF12L2 Anticorps).
increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others
Data suggest that p62 (Montrer GTF2H1 Anticorps) and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy.
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.
Alfy might target cytosolic protein aggregates for autophagic degradation.
Data provide a novel association between WDFY3 and the RANKL (Montrer TNFSF11 Anticorps)-induced osteoclastogenesis pathway via the modulation of TRAF6 (Montrer TRAF6 Anticorps).
Alfy translocalization likely is involved in the pathogenesis of amyotrophic lateral sclerosis.
Wdfy3 is important in regulating neural progenitor divisions, neural migration, cerebral expansion and functional organization in the developing brain. Loss-of-function leads to pathological changes characteristic of autism spectrum disorders.
gene expression profiling; in situ hybridization analysis revealed that the expressed BWF1 mRNA was restricted to the marginal region both in E14 (Montrer NPAT Anticorps) and E16 (Montrer SLC7A5 Anticorps) embryonic brain, but became diffuse after birth
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy.
WD repeat and FYVE domain containing 3
, WD repeat and FYVE domain-containing protein 3
, autophagy-linked FYVE protein
, beach domain, WD repeat and FYVE domain-containing protein 1
, galactosyltransferase 3 beta 1, 4