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The protein encoded by WDHD1 contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. De plus, nous expédions WDHD1 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal WDHD1 Primary Antibody pour ICC, IF - ABIN4365949
Sato, Koinuma, Fujita, Hosokawa, Ito, Tsuchiya, Kondo, Nakamura, Daigo: Activation of WD repeat and high-mobility group box DNA binding protein 1 in pulmonary and esophageal carcinogenesis. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2010
Show all 2 Pubmed References
Dna2 (Montrer DNA2 Anticorps) co-localizes in foci with RPA (Montrer RPA1 Anticorps) and is found in a complex with replication fork components And-1 and Mcm10 (Montrer MCM10 Anticorps). Dna2 (Montrer DNA2 Anticorps) interacts with the DSB repair and checkpoint proteins Nbs1 (Montrer NLRP2 Anticorps) and ATM (Montrer ATM Anticorps).
And-1 interacts with CtIP (Montrer RBBP8 Anticorps) and that these interactions are required for DNA damage checkpoint maintenance, thereby linking DNA processing with prolonged cell cycle arrest to allow sufficient time for DNA repair.
important role of And-1 in homologous recombination repair by regulating CtIP (Montrer RBBP8 Anticorps)-mediated DNA double-strand break end resection
The WDHD1 gene, one of the genes that is upregulated in human papillomavirus E7-expressing cells, was found to play an important role in E7-induced G1 checkpoint abrogation and rereplication
Results provide additional evidence suggesting that WDHD1 is involved in the mismatch repair pathway.
RecQL4 (Montrer RECQL4 Anticorps)-dependent association of Mcm10 (Montrer MCM10 Anticorps) and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells.
And-1 coordinates with Claspin (Montrer CLSPN Anticorps) for efficient Chk1 (Montrer CHEK1 Anticorps) activation in response to replication stress.
The Ctf4-CMG complex contains a homodimeric Ctf4 that acts as a platform linking polymerase alpha to the monomeric hCMG complex.
And-1 together with HJURP (Montrer HJURP Anticorps) regulates the assembly of new CENP-A (Montrer CENPA Anticorps) onto centromeres.
Human And-1 facilitates loading of the MCM2-7 (Montrer MCM2 Anticorps) helicase onto chromatin during the assembly of prereplicative complex.
Data show that And-1 forms a complex with both histone H3 and Gcn5.
The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms.
WD repeat and HMG-box DNA-binding protein 1
, WD repeat and HMG-box DNA binding protein 1
, WD repeat and HMG-box DNA-binding protein 1-like
, AND-1 protein
, acidic nucleoplasmic DNA-binding protein 1
, Acidic nucleoplasmic DNA-binding protein 1
, CTF4, chromosome transmission fidelity factor 4 homolog