YME1-Like 1 (S. Cerevisiae) (YME1L1) Kits ELISA

The protein encoded by YME1L1 is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. De plus, nous expédions YME1-Like 1 (S. Cerevisiae) Anticorps (28) et YME1-Like 1 (S. Cerevisiae) Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Souris YME1L1 YME1L1 27377 O88967
Anti-Rat YME1L1 YME1L1 114217  
YME1L1 10730 Q96TA2
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 0.115 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests 13 to 16 Days

Plus Kits ELISA pour YME1-Like 1 (S. Cerevisiae) partenaires d'interaction

Mouse (Murine) YME1-Like 1 (S. Cerevisiae) (YME1L1) interaction partners

  1. Data suggest that in a mouse model of neonatal hypoxic-ischemic brain injury, the expression of mitochondrial shaping proteins, such as OPA1 and Yme1L, are altered; in vitro and in vivo, OPA1 is cleaved to shorter forms and Yme1L expression is reduced.

  2. Constitutive OPA1 cleavage by YME1L and OMA1 at two distinct sites leads to the accumulation of both long and short forms of OPA1 and maintains mitochondrial fusion.

Human YME1-Like 1 (S. Cerevisiae) (YME1L1) interaction partners

  1. Data show that engineered YME1L protease discriminates between degradation signals by amino acid composition, implying the use of sequence-specific signals in mitochondrial proteostasis.

  2. These results identify mutations in YME1L1 as a cause of a mitochondriopathy with optic nerve atrophy highlighting the importance of YME1L1 for mitochondrial functionality in humans.

  3. YME1L1 was identified as the first NUMT (nuclear mtDNA) suppressor gene in human and demonstrate that inactivation of YME1L1 induces migration of mtDNA to the nuclear genome.

  4. differential stress-induced degradation of YME1L and OMA1 as a mechanism for sensitively adapting mitochondrial inner membrane protease activity and function in response to distinct types of cellular insults.

  5. YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress.Loss of YME1L compromises the regulation of mitochondrial inner membrane proteostasis.

  6. Results reveal a crucial role for YME1L in the maintenance of mitochondrial inner-membrane proteostasis and in the proteolytic regulation of respiratory chain biogenesis.

YME1-Like 1 (S. Cerevisiae) (YME1L1) profil antigène

Antigen Summary

The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with YME1L1

  • YME1-like 1 (S. cerevisiae) (Yme1l1) anticorps
  • YME1-like 1 ATPase (Yme1l1) anticorps
  • YME1 like 1 ATPase (YME1L1) anticorps
  • FTSH anticorps
  • FtsH1 anticorps
  • MEG4 anticorps
  • PAMP anticorps
  • YME1L anticorps

Protein level used designations for YME1L1

ATP-dependent metalloprotease FtsH1 , ATP-dependent zinc metalloprotease YME1L1 , YME1-like protein 1 , ATP-dependent metalloprotease YME1L1 , meg-4 , ATP-dependent metalloprotease FtsH1 homolog , presenilin-associated metalloprotease , ATP-dependent metalloprotease YME1L1-like protein , ATP-dependent zinc metalloprotease YME1l1-like protein

27377 Mus musculus
114217 Rattus norvegicus
10730 Homo sapiens
477988 Canis lupus familiaris
505118 Bos taurus
100065311 Equus caballus
100352946 Oryctolagus cuniculus
101865981 Macaca fascicularis
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