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Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). De plus, nous expédions ZC3HC1 Anticorps (67) et ZC3HC1 Kits (2) et beaucoup plus de produits pour cette protéine.
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Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2).
Results reveal a novel role for NIPA in meiosis.
phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner
NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events
Common nonsynonymous coding variant in ZC3HC1 (rs11556924) is associated with protection from coronary artery disease.
This study shows that the Coronary Artery Disease-associated coding polymorphism in ZC3HC1 alters the dynamics of cell-cycle regulation by NIPA.
ZC3HC1 rs11556924 polymorphism is associated with hypertension in a Finnish cohort.
Results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in rheumatoid arthritis.
The NIPA protein is a human F-box-containing protein that defines an SCF-type E3 ligase (SCF(NIPA)) controlling mitotic entry.
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity).
, nuclear interacting partner of ALK
, nuclear interacting partner of anaplastic lymphoma kinase (Alk)
, nuclear-interacting partner of ALK
, nuclear-interacting partner of anaplastic lymphoma kinase
, zinc finger C3HC-type protein 1
, hematopoietic stem/progenitor cell protein 216
, nuclear interacting partner of anaplastic lymphoma kinase (ALK)
, zinc finger, C3HC-type 1