Zinc Finger, C3HC-Type Containing 1 Protéines (ZC3HC1)

Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). De plus, nous expédions ZC3HC1 Anticorps (67) et ZC3HC1 Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
ZC3HC1 232679 Q80YV2
ZC3HC1 51530 Q86WB0
Rat ZC3HC1 ZC3HC1 296957  
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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Levure Xenopus tropicalis His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,349.50
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ZC3HC1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human ,
,

Plus protéines pour Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) partenaires d'interaction

Mouse (Murine) Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) interaction partners

  1. Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2 (Montrer MAPK1 Protéines)).

  2. Results reveal a novel role for NIPA in meiosis.

  3. phosphorylated NIPA is degraded in late mitosis in an APC (Montrer APC Protéines)/C(Cdh1 (Montrer CDH1 Protéines))-dependent manner

  4. NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events

Human Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) interaction partners

  1. Common nonsynonymous coding variant in ZC3HC1 (rs11556924) is associated with protection from coronary artery disease.

  2. This study shows that the Coronary Artery Disease-associated coding polymorphism in ZC3HC1 alters the dynamics of cell-cycle regulation by NIPA.

  3. ZC3HC1 rs11556924 polymorphism is associated with hypertension in a Finnish cohort.

  4. Results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in rheumatoid arthritis.

  5. The NIPA protein is a human F-box-containing protein that defines an SCF (Montrer KITLG Protéines)-type E3 ligase (SCF (Montrer KITLG Protéines)(NIPA)) controlling mitotic entry.

  6. Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2 (Montrer MAPK1 Protéines)).

  7. phosphorylated NIPA is degraded in late mitosis in an APC (Montrer APC Protéines)/C(Cdh1 (Montrer CDH1 Protéines))-dependent manner

  8. NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events

Profil protéine ZC3HC1

Profil protéine

Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity).

Gene names and symbols associated with ZC3HC1

  • zinc finger, C3HC type 1 (Zc3hc1)
  • zinc finger C3HC-type containing 1 (ZC3HC1)
  • zinc finger, C3HC-type containing 1 (Zc3hc1)
  • 1110054L24Rik Protéine
  • AU018540 Protéine
  • AU019789 Protéine
  • HSPC216 Protéine
  • NIPA Protéine
  • RGD1561099 Protéine

Protein level used designations for ZC3HC1

mNIPA , nuclear interacting partner of ALK , nuclear interacting partner of anaplastic lymphoma kinase (Alk) , nuclear-interacting partner of ALK , nuclear-interacting partner of anaplastic lymphoma kinase , zinc finger C3HC-type protein 1 , hematopoietic stem/progenitor cell protein 216 , nuclear interacting partner of anaplastic lymphoma kinase (ALK) , zinc finger, C3HC-type 1

GENE ID SPECIES
232679 Mus musculus
51530 Homo sapiens
296957 Rattus norvegicus
100174537 Pongo abelii
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