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Uridylyltransferase that mediates the terminal uridylation of some specific RNAs. De plus, nous expédions ZCCHC6 Anticorps (7) et et beaucoup plus de produits pour cette protéine.
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Results from a study on gene expression variability markers in early-stage human embryos shows that TUT7 (ZCCHC6) is a putative expression variability marker for the 3-day, 8-cell embryo stage.
Following an intratracheal challenge with S. pneumoniae, Zcchc6 deficiency led to a modest but significant increase in the expression of select cytokines including IL-6, CXCL1, and CXCL5. These findings were recapitulated in vitro whereby Zcchc6-deficient macrophages exhibited similar increases in cytokine expression due to bacterial stimulation
The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU).
Knockdown of 3'hExo also altered the uridylation of histone mRNAs, suggesting that TUT7 and 3'hExo function together in trimming and uridylating histone mRNAs
TUT7 generates an oligo-U tail in microRNAs that leads to degradation.
Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway.
Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway.
Lin28 uses two different TUTases to control let-7 expression .
Uridylyltransferase that mediates the terminal uridylation of some specific RNAs. Not involved in uridylation of precursor let-7 (pre-let-7) miRNA. Does not play a role in replication-dependent histone mRNA degradation (By similarity).
PAP associated domain containing 6
, TUTase 7
, terminal uridylyltransferase 7
, zinc finger CCHC domain-containing protein 6