Zinc Metalloproteinase, Ste24 Protéines (Zmpste24)

Zmpste24 encodes a member of the peptidase M48A family. De plus, nous expédions Zinc Metalloproteinase, Ste24 Anticorps (128) et Zinc Metalloproteinase, Ste24 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Zmpste24 10269 O75844
Zmpste24 313564  
Zmpste24 230709 Q80W54
Comment commander chez anticorps-enligne
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Commandez enligne
  • orders@anticorps-enligne.fr

Top Zinc Metalloproteinase, Ste24 Protéines sur anticorps-enligne.fr

Showing 6 out of 7 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,626.01
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,355.45
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Escherichia coli (E. coli) Humain Inconjugué   5 applications Connectez-vous pour afficher 1 to 2 Days
$318.85
Détails

Zmpste24 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Rat (Rattus)
Mouse (Murine) ,
,

Plus protéines pour Zinc Metalloproteinase, Ste24 (Zmpste24) partenaires d'interaction

Human Zinc Metalloproteinase, Ste24 (Zmpste24) interaction partners

  1. ZMPSTE24 is a downstream effector of IFITM3 (Montrer IFITM3 Protéines) and is important for interferon (Montrer IFNA Protéines)-induced transmembrane antiviral activity.

  2. ZMPSTE24 is an important element for innate host defense against a broad spectrum of pathogenic viruses.

  3. This case demonstrates that accumulation of prelamin A, independent of the loss of function of ZMPSTE24 metallopeptidase (Montrer ECEL1 Protéines) that catalyzes processing of prelamin A, can cause a progeroid disorder and that a cell biology assay could be used in precision medicine to identify a potential therapy.

  4. used a fluorogenic assay of the activity of purified ZMPSTE24 to demonstrate that HIV protease inhibitors directly inhibit the human enzyme in a manner indicative of a competitive mechanism

  5. the present study suggests that inhibition of ZMPSTE24 by both mutational and expressional pathways might together play a role in tumorigenesis of colorectal cancer and gastric cancer harboring microsatellite instability phenotype.

  6. results establish that the substrate profile of Ste24p is broader than anticipated, being more similar to that of the M16A protease family than that of the Rce1p CAAX protease with which it has been functionally associated

  7. ZMPSTE24 downregulation is a major contributor in VSMC dysfunctions resulting from LMNA (Montrer LMNA Protéines) mutations or PI treatments that could translate in early atherosclerosis at the clinical level.

  8. Here, we report on a familial c.50delA (p.Lys17Serfs*21) mutation of the ZMPSTE24 gene, causing RD in two siblings.

  9. complete loss-of-function of ZMPSTE24 leads to RD, whereas other less severe phenotypes are associated with at least one haploinsufficient allele.

  10. miR (Montrer MLXIP Protéines)-141-3p, which is overexpressed during senescence as a result of epigenetic regulation, is able to decrease ZMPSTE24 expression levels, and leads to an upregulation of prelamin A in human mesenchymal stem cells.

Mouse (Murine) Zinc Metalloproteinase, Ste24 (Zmpste24) interaction partners

  1. these findings suggest that downregulated miR3425p is involved in regulating cell proliferation and cell cycles in Zmpste24/ MEFs by suppressing GAS2 (Montrer GAS2 Protéines) in vitro.

  2. ZMPSTE24 is a downstream effector of IFITM3 (Montrer IFITM3 Protéines) and is important for interferon (Montrer IFNA Protéines)-induced transmembrane antiviral activity.

  3. ZMPSTE24 is an important element for innate host defense against a broad spectrum of pathogenic viruses.

  4. we identified the abnormal lamin A (prelamin A), accompanied by a down-regulation of a lamin A processing enzyme (Zmpste24) in the kidney of the GMF transgenic mice

  5. In Zmpste24(-/-) mice, histone H4 was hypoacetylated at a lysine 16 residue (H4K16), and this defect was attributed to the reduced association of a histone acetyltransferase, Mof (Montrer KAT8 Protéines), to the nuclear matrix.

  6. Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

  7. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

  8. Zmpste24 has a role in processing of prelamin A and lack of Zmpste24 results in a brittle bone phenotype

  9. the progeria-like phenotypes caused by the lack of Zmpste24 in knockout mice is eliminated by heterozygosity for Lmna (Montrer LMNA Protéines)

  10. Lack of functional Zmpste24, a metalloproteinase responsible for the maturation of prelamin A, also results in progeroid phenotypes in mice

Profil protéine Zinc Metalloproteinase, Ste24 (Zmpste24)

Profil protéine

This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.

Gene names and symbols associated with Zmpste24

  • zinc metallopeptidase STE24 (ZMPSTE24)
  • zinc metallopeptidase STE24 L homeolog (zmpste24.L)
  • zinc metallopeptidase STE24 (zmpste24)
  • CAAX prenyl protease (zmpste24)
  • Peptidase family M48 family protein (ATSTE24)
  • zinc metallopeptidase STE24 (Zmpste24)
  • zinc metallopeptidase, STE24 (Zmpste24)
  • zinc metallopeptidase, STE24 homolog (zmpste24)
  • A530043O15Rik Protéine
  • D030046F19 Protéine
  • DDBDRAFT_0189115 Protéine
  • DDBDRAFT_0237846 Protéine
  • DDB_0189115 Protéine
  • DDB_0237846 Protéine
  • F2N1.21 Protéine
  • F2N1_21 Protéine
  • Face-1 Protéine
  • FACE1 Protéine
  • fi45a02 Protéine
  • HGPS Protéine
  • MADB Protéine
  • PRO1 Protéine
  • STE24 Protéine
  • Ste24p Protéine
  • wu:fi45a02 Protéine
  • zgc:55655 Protéine

Protein level used designations for Zmpste24

zinc metallopeptidase (STE24 homolog, S. cerevisiae) , zinc metallopeptidase (STE24 homolog) , zinc metallopeptidase STE24 homolog , zinc metalloproteinase STE24 homolog , CAAX prenyl protease 1 homolog , STE24 endopeptidase , zinc metalloproteinase , zinc metallopeptidase STE24 , CAAX prenyl protease 1 homolog-like , farnesylated proteins-converting enzyme 1 , prenyl protein-specific endoprotease 1 , zinc metalloproteinase Ste24 homolog , zinc metallopeptidase, STE24 homolog , zinc metalloproteinase, STE24 homolog , farnesylated-proteins converting enzyme 1 , zinc metalloproteinase (STE24 homolog, yeast)

GENE ID SPECIES
419572 Gallus gallus
447784 Xenopus laevis
456790 Pan troglodytes
482460 Canis lupus familiaris
550009 Xenopus (Silurana) tropicalis
693765 Macaca mulatta
8627861 Dictyostelium discoideum AX4
100032108 Monodelphis domestica
100339077 Oryctolagus cuniculus
100404786 Callithrix jacchus
100445390 Pongo abelii
100475834 Ailuropoda melanoleuca
100557771 Anolis carolinensis
100580430 Nomascus leucogenys
828209 Arabidopsis thaliana
538104 Bos taurus
10269 Homo sapiens
313564 Rattus norvegicus
230709 Mus musculus
334380 Danio rerio
Fournisseurs de qualité sélectionnés pour Zinc Metalloproteinase, Ste24 Protéines (Zmpste24)
Avez-vous cherché autre chose?