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Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. De plus, nous expédions aHSP Anticorps (52) et aHSP Protéines (15) et beaucoup plus de produits pour cette protéine.
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In the presence of free alpha subunits and H2O2, both HbA and HbE (Montrer HBe1 Kits ELISA) showed bCys93 oxidation which increased with higher H2O2 concentrations. In the presence of Alpha-hemoglobin stabilizing protein (AHSP)Cys93 oxidation was substantially reduced in both proteins.in the presence of excess free alpha-subunit (Montrer POLG Kits ELISA) and under the same oxidative conditions, these events are substantially increased for HbE (Montrer HBe1 Kits ELISA) compared to HbA
Findings indicate that alpha-hemoglobin-stabilizing protein (AHSP) expression is a biomarker of hemoglobin (Montrer HBB Kits ELISA) H (HbH (Montrer HBA1 Kits ELISA)) disease severity and infer an important role of AHSP in modulating the pathophysiology of this disease.
AHSP is predominantly expressed in erythroid precursors in bone marrow biopsy specimens from patients with hematologic malignancies.
AHSP expression was higher in patients with sickle cell anemia versus thalassemia, with no significant difference between BTM and BTI. Expression was higher in patients with NTDT and on hydroxyurea therapy.
In maturing RBC (Montrer CACNA1C Kits ELISA) progenitors AHSP bind to free alpha-globin (Montrer HBA1 Kits ELISA) chains to increase the HbA production. (Review)
analysis showed binding of STAT3 (Montrer STAT3 Kits ELISA) to AHSP promoter and binding was significantly augmented with IL6 (Montrer IL6 Kits ELISA) stimulation and upon alpha-globin (Montrer HBA1 Kits ELISA) overexpression
The relationship between AHSP gene expression, disease severity, and the beta/alpha globin (Montrer HBA1 Kits ELISA) mRNA ratio was studied among different homozygote beta-thalassemia patients.
alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy (Montrer GCG Kits ELISA)-alpha-hemoglobin and weakens the iron-oxygen bond.
alpha-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha-subunits of human HbA with hydrogen peroxide.
AHSP acts as a molecular chaperone (Montrer HSP90AA1 Kits ELISA) by rapidly binding and stabilizing met-alpha hemichrome folding intermediates
role of alpha-hemoglobin stabilizing protein in hemoglobin assembly
Endogenous AHSP is not limiting for alpha-globin (Montrer HBA-A1 Kits ELISA) detoxification in beta-thalassemic mice.
activin A (Montrer INHBA Kits ELISA) does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh (Montrer SHH Kits ELISA)-dependent mechanism
Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia.
These results support the hypothesis that EKLF (Montrer KLF1 Kits ELISA) acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin (Montrer HBB Kits ELISA) genes and indicate that EKLF (Montrer KLF1 Kits ELISA) may play similar roles for other erythroid genes.
developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF (Montrer KLF1 Kits ELISA) might be one of the steps necessary for the switch-on of the mammalian adult beta globin (Montrer HBB Kits ELISA) gene transcription
AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly
The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein (Montrer PRNP Kits ELISA) on the cell surface is reported.
Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).
alpha hemoglobin stabilizing protein
, erythroid associated factor
, alpha hemoglobin stabilising protein
, alpha-hemoglobin-stabilizing protein
, erythroid differentiation associated factor
, erythroid differentiation-related factor
, erythroid-associated factor