anti-alpha Ketoglutarate Dehydrogenase (alphaKGDHC) Anticorps

alphaKGDHC encodes one subunit of the 2-oxoglutarate dehydrogenase complex. De plus, nous expédions alpha Ketoglutarate Dehydrogenase Kits (16) et alpha Ketoglutarate Dehydrogenase Protéines (8) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
alphaKGDHC 4967 Q02218
alphaKGDHC 18293 Q60597
alphaKGDHC 360975 Q5XI78
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Top anti-alpha Ketoglutarate Dehydrogenase Anticorps sur

Showing 10 out of 69 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB Host: Rabbit Target Name: OGDH Sample Tissue: Human DLD1 Antibody Dilution: 1.0ug/ml WB Suggested Anti-OGDH Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Human Liver 100 μL 2 to 3 Days
Humain Lapin Inconjugué ICC, IF, IHC (p), WB ICC/IF Image OGDH antibody [C2C3], C-term detects OGDH protein at Mitochondria by immunofluorescent analysis. Sample: HeLa cells were fixed in -20℃ 100% MeOH for 5 min. Green: OGDH protein stained by OGDH antibody [C2C3], C-term , diluted at 1:500. Blue: Hoechst 33343 staining. IHC-P Image OGDH antibody [C2C3], C-term detects OGDH protein at mitochondria on mouse muscle by immunohistochemical analysis. Sample: Paraffin-embedded mouse muscle. OGDH antibody [C2C3], C-term , dilution: 1:500. 100 μL 3 to 4 Days
Roussette (Chauve-souris) Lapin Inconjugué WB 100 μL 11 to 14 Days
Humain Lapin Inconjugué IHC, WB ABIN6272971 at 1/100 staining Rat liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of mouse lung tissue, using OGDH antibody. 100 μL 11 to 12 Days
Humain Lapin Inconjugué IF, IHC, WB Western blot analysis of extracts of various cell lines, using OGDH Antibody. Immunohistochemistry of paraffin-embedded rat brain using OGDH antibody. 200 μL 12 to 14 Days
Humain Lapin Inconjugué IHC (p), WB Western blot analysis in NCI-H460 cell line lysates (35ug/lane). OGDH Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
Humain Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13 to 16 Days
Humain Lapin Inconjugué ELISA, WB 100 μL 2 to 3 Days
Humain Lapin Inconjugué IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using OGDH antibody (ABIN5973793) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat ovary using OGDH antibody (ABIN5973793) at dilution of 1/100 (20x lens). 100 μL 11 to 16 Days
Humain Lapin Inconjugué WB OGDH antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days

anti-alpha Ketoglutarate Dehydrogenase Anticorps mieux référencés

  1. Human Polyclonal alphaKGDHC Primary Antibody pour IF, IHC - ABIN6684588 : Stein, Jadiya, Zhang, McLendon, Abouassaly, Witmer, Anderson, Elrod, Boudreau: Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency. dans Cell reports 2018 (PubMed)

Plus d’anticorps contre alpha Ketoglutarate Dehydrogenase partenaires d’interaction

Human alpha Ketoglutarate Dehydrogenase (alphaKGDHC) interaction partners

  1. The data indicate that amino acid/nucleotide metabolism-related genes OGDH, PPAT and PCCA acquire somatic mutations in microsatellite instability-high gastric cancers and colorectal cancers and that mutational intratumoral heterogeneity may occur in at least some of these tumors.

  2. PIK3CA mutant cancer cells require PIK3CA but also require the expression of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH).

  3. oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS), which when mutated stabilize HIF1alpha in a non-hydroxylated form.

  4. Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types

  5. ATP consumption is demonstrated in respiration-impaired isolated mice and in situ neuronal mitochondria from transgenic mice with dihydrolipoyl succinyltransferase deficiency.

  6. Acute inhibition of alpha-ketoglutarate dehydrogenase produces effects on calcium opposite to those in Alzheimer's disease (AD), while the chronic or long-term inhibition of alpha-KGDHC mimicked the AD-related changes in calcium.

  7. Differences in oxoglutarate dehydrogenase activity suggest that there is no excess mitochondrial capacity during maximal exercise with a small muscle mass.

  8. 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability is regulated by the RING finger ubiquitin ligase Siah

  9. Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.

  10. Association with autosomal recessive DOOR syndrome not found.

Mouse (Murine) alpha Ketoglutarate Dehydrogenase (alphaKGDHC) interaction partners

  1. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL-dependent manner

  2. Taken together, our results indicate that the redox sensing and ROS forming properties of Pdh and Ogdh are linked to S-glutathionylation

  3. pre-incubation of permeabilized liver mitochondria from mouse depleted of GSH showed an approximately ~3.5-fold increase in Ogdh-mediated O2(-)/H2O2 production that was matched by a significant decrease in NADH formation which could be reversed by Grx2. Taken together, our results demonstrate GSH and GSSG modulate ROS production by Ogdh through S-glutathionylation of different subunits

  4. The nitration degree of alpha-OGDH for diabetic mouse is higher than that for control mouse, indicating that alpha-OGDH of the diabetic mouse suffered from more intense oxidative damage.

  5. Alpha-ketoglutarate dehydrogenase is a primary site of ROS production in normally functioning mitochondria.

  6. In the postnatal mouse brain,high mRNA levels of d1401/Ogdh were observed in the olfactory bulb, hippocampus, cerebellum, and pons.

  7. Early detection in thiamine deficiency induce changes in the transcription of this enzyme in brain mitochondria.

alpha Ketoglutarate Dehydrogenase (alphaKGDHC) profil antigène

Profil protéine

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with alphaKGDHC

  • oxoglutarate dehydrogenase (OGDH) anticorps
  • oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (Ogdh) anticorps
  • oxoglutarate dehydrogenase (Ogdh) anticorps
  • 2210403E04Rik anticorps
  • 2210412K19Rik anticorps
  • AA409584 anticorps
  • AKGDH anticorps
  • d1401 anticorps
  • E1k anticorps
  • mKIAA4192 anticorps
  • OGDC anticorps

Protein level used designations for alphaKGDHC

2-oxoglutarate dehydrogenase, mitochondrial , 2-oxoglutarate dehydrogenase complex component E1 , OGDC-E1 , oxoglutarate decarboxylase , oxoglutarate dehydrogenase (succinyl-transferring) , 2-oxoglutarate dehydrogenase E1 component, mitochondrial , alpha-ketoglutarate dehydrogenase , oxoglutarate dehydrogenase (lipoamide)

426429 Gallus gallus
4967 Homo sapiens
475499 Canis lupus familiaris
534599 Bos taurus
18293 Mus musculus
360975 Rattus norvegicus
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