alpha Ketoglutarate Dehydrogenase Protéines (alphaKGDHC)

alphaKGDHC encodes one subunit of the 2-oxoglutarate dehydrogenase complex. De plus, nous expédions alpha Ketoglutarate Dehydrogenase Anticorps (54) et alpha Ketoglutarate Dehydrogenase Kits (32) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
alphaKGDHC 4967 Q02218
alphaKGDHC 18293 Q60597
Rat alphaKGDHC alphaKGDHC 360975 Q5XI78
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Showing 6 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 10 to 12 Days
Escherichia coli (E. coli) Humain His tag Validation with Western Blot 50 μg Connectez-vous pour afficher 10 to 12 Days
Levure Hamsters dorés syriens His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
Escherichia coli (E. coli) Humain T7 tag,His tag 100 μg Connectez-vous pour afficher 15 to 18 Days

alphaKGDHC Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour alpha Ketoglutarate Dehydrogenase (alphaKGDHC) partenaires d'interaction

Human alpha Ketoglutarate Dehydrogenase (alphaKGDHC) interaction partners

  1. oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS (Montrer LIAS Protéines)), which when mutated stabilize HIF1alpha (Montrer HIF1A Protéines) in a non-hydroxylated form.

  2. Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types

  3. Acute inhibition of alpha-ketoglutarate dehydrogenase produces effects on calcium opposite to those in Alzheimer's disease (AD), while the chronic or long-term inhibition of alpha-KGDHC mimicked the AD-related changes in calcium.

  4. 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability is regulated by the RING finger ubiquitin ligase Siah

  5. Reduction in the E2k (Montrer DLST Protéines) subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.

Mouse (Murine) alpha Ketoglutarate Dehydrogenase (alphaKGDHC) interaction partners

  1. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL (Montrer APOC4 Protéines)-dependent manner

  2. Taken together, our results indicate that the redox sensing and ROS (Montrer ROS1 Protéines) forming properties of Pdh (Montrer PDP Protéines) and Ogdh are linked to S-glutathionylation

  3. pre-incubation of permeabilized liver mitochondria from mouse depleted of GSH showed an approximately ~3.5-fold increase in Ogdh-mediated O2(-)/H2O2 production that was matched by a significant decrease in NADH formation which could be reversed by Grx2 (Montrer GRX2 Protéines). Taken together, our results demonstrate GSH and GSSG modulate ROS (Montrer ROS1 Protéines) production by Ogdh through S-glutathionylation of different subunits

  4. The nitration degree of alpha-OGDH for diabetic mouse is higher than that for control mouse, indicating that alpha-OGDH of the diabetic mouse suffered from more intense oxidative damage.

  5. Alpha-ketoglutarate dehydrogenase is a primary site of ROS (Montrer ROS1 Protéines) production in normally functioning mitochondria.

  6. In the postnatal mouse brain,high mRNA levels of d1401/Ogdh were observed in the olfactory bulb, hippocampus, cerebellum, and pons.

Profil protéine alpha Ketoglutarate Dehydrogenase (alphaKGDHC)

Profil protéine

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with alphaKGDHC

  • oxoglutarate dehydrogenase (OGDH)
  • oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (Ogdh)
  • oxoglutarate dehydrogenase (Ogdh)
  • 2210403E04Rik Protéine
  • 2210412K19Rik Protéine
  • AA409584 Protéine
  • AKGDH Protéine
  • d1401 Protéine
  • E1k Protéine
  • mKIAA4192 Protéine
  • OGDC Protéine

Protein level used designations for alphaKGDHC

2-oxoglutarate dehydrogenase, mitochondrial , 2-oxoglutarate dehydrogenase complex component E1 , OGDC-E1 , oxoglutarate decarboxylase , oxoglutarate dehydrogenase (succinyl-transferring) , 2-oxoglutarate dehydrogenase E1 component, mitochondrial , alpha-ketoglutarate dehydrogenase , oxoglutarate dehydrogenase (lipoamide)

426429 Gallus gallus
4967 Homo sapiens
475499 Canis lupus familiaris
534599 Bos taurus
18293 Mus musculus
360975 Rattus norvegicus
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