anthrax Toxin Receptor 1 (ANTXR1) Kits ELISA

ANTXR1 encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. De plus, nous expédions anthrax Toxin Receptor 1 Anticorps (170) et anthrax Toxin Receptor 1 Protéines (14) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
ANTXR1 84168 Q9H6X2
ANTXR1 69538 Q9CZ52
ANTXR1 362393 Q0PMD2
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 15.6 pg/mL 62.5-4000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days

Plus Kits ELISA pour anthrax Toxin Receptor 1 partenaires d'interaction

Human anthrax Toxin Receptor 1 (ANTXR1) interaction partners

  1. The frequency of the CC genotype of rs4527238 was observed to be high in the low HbF patient group compared to the high HbF group.

  2. Consistent with experimental study, computational results indicate the metal ion in TEM8 contributes significantly to the binding affinity, and anthrax protective antigen-TEM8 binding is more favorable in the presence of Mg(2+) than Ca(2+) .

  3. TEM8 is a novel receptor for uPA

  4. Our findings implicate ANTXR1 as a candidate gene for isolated TA, suggest the involvement of specific hypomorphic alleles, and expand the previously known ANTXR1-associated phenotypes.

  5. Results demonstrate that the capsid footprint on the receptor is not conserved in anthrax toxin receptor 2 (ANTXR2), thereby providing a molecular mechanism for explaining the exquisite selectivity of SVV for ANTXR1.

  6. Silencing TEM8 may inhibit proliferation of XWLC05 lung cancer cells, promote cell apoptosis, arrest the cell cycle at G1 phase and decrease the migration and invasive ability.

  7. Novel targets ANTXR1 and RSPO2 were confirmed to be suppressed by miR-493 directly.

  8. These studies identify ANTXR1, a class of receptor that is shared by a mammalian virus and a bacterial toxin, as the cellular receptor for Seneca Valley virus.

  9. expression does not affect cytotoxicity to anthrax toxin

  10. Findings suggest that down-regulation of tumor endothelial marker 8 play an important role in the inhibition of tumorigenesis and development of osteosarcoma.

  11. TEM8 may be differentially expressed between wound types and loss of this molecule impacts HaCaT growth and migration, potentially implicating this molecule as a factor involved in successful progression of wound healing.

  12. In the absence of any N-linked glycans, TEM8 fails to fold correctly and is recognized by the ER quality control machinery.

  13. These studies expand the allelic spectrum in this rare condition and potentially provide insight into the role of ANTXR1 in the regulation of the extracellular matrix.

  14. TEM8-targeted siRNAs also offered significant protection against lethal toxin in human macrophage-like cells.

  15. ANTXR2 is expressed by human uterine smooth muscle cell and appears important for normal human uterine smooth muscle cell viability, migration and contractility.

  16. High ANTXR1 accelerates breast tumor growth and lung metastasis.

  17. There is an attenuation of ANTXR1 expression post-infection which may be a protective mechanism that has evolved to prevent reinfection.

  18. Mutations affecting ANTXR1 function are responsible for GAPO syndrome's characteristic generalized defect in extracellular-matrix homeostasis.

  19. Two new splice variants, one encoding a membrane-bound form of the receptor and the other secreted, which we have designated V4 and V5 (the latter being the only variant expressed in the prostate).

  20. An acidic region in the cytosolic tail of ANTXR1 decreases actin association, sending a signal that prevents binding of ANTXR1 to the protective antigen and providing evidence that cytoskeletal dynamics regulate ANTXR1 function.

Mouse (Murine) anthrax Toxin Receptor 1 (ANTXR1) interaction partners

  1. ANTXR1 has a role in the regulation of RANKL-induced osteoclast differentiation and function

  2. Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting.

  3. An essential physiologic role for Antxr1 in arteriogenesis and peripheral artery disease.

  4. Data demonstrate that TEM8 is an essential regulator of connective tissue homeostasis. it controls synthesis of major matrix components in both endothelial and fibroblastic cells and regulates signaling pathways and matrix degradation.

  5. Anthrax toxin receptors in mouse and human macrophages were silenced using targeted siRNAs or blocked with specific antibody prior to challenge with anthrax lethal toxin.

  6. These results strongly suggest that TEM8 is the only minor anthrax toxin receptor mediating direct lethality in vivo and that other proteins implicated as receptors do not play this role.

  7. This is the first demonstration that the ATR/TEM8 protein is highly expressed in epithelial cells, suggesting that the ATR/TEM8 expression pattern is highly relevant for understanding the pathogenesis of anthrax infection.

  8. The mRNA transcripts of both receptors, ANTXR1 and ANTXR2 were detected in J774A.1 cells and mouse tissues suggesting that anthrax edema toxin and B. anthracis Sterne spore are involved in the ANTXR mRNA regulation in host cells.

  9. Data show that the lethality of anthrax toxin for mice is mostly mediated by CMG2 and that TEM8 plays only a minor role.

  10. Host-derived TEM8 promotes the growth of certain tumors.

anthrax Toxin Receptor 1 (ANTXR1) profil antigène

Antigen Summary

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Gene names and symbols associated with ANTXR1

  • anthrax toxin receptor 1 (ANTXR1) anticorps
  • anthrax toxin receptor 1 (Antxr1) anticorps
  • 2310008J16Rik anticorps
  • 2810405N18Rik anticorps
  • Antrx1 anticorps
  • ANTXR1 anticorps
  • ATR anticorps
  • Tem8 anticorps

Protein level used designations for ANTXR1

anthrax toxin receptor 1 , tumor endothelial marker 8 , anthrax toxin receptor 1-like , 2310008J16Rik , 2810405N18Rik

470393 Pan troglodytes
612601 Canis lupus familiaris
100061334 Equus caballus
100357637 Oryctolagus cuniculus
100410030 Callithrix jacchus
100425392 Macaca mulatta
100513853 Sus scrofa
100598321 Nomascus leucogenys
84168 Homo sapiens
69538 Mus musculus
362393 Rattus norvegicus
616010 Bos taurus
428199 Gallus gallus
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