anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) Anticorps

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. De plus, nous expédions beta-Site APP-Cleaving Enzyme 2 Kits (40) et beta-Site APP-Cleaving Enzyme 2 Protéines (14) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
BACE2 25825 Q9Y5Z0
BACE2 56175 Q9JL18
BACE2 288227 Q6IE75
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Top anti-beta-Site APP-Cleaving Enzyme 2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 152 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-BACE2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  PANC1 cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-BACE2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  ACHN cell lysate BACE2 is supported by BioGPS gene expression data to be expressed in ACHN WB Suggested Anti-BACE2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: ACHN cell lysate  BACE2 is supported by BioGPS gene expression data to be expressed in ACHN 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: BACE2 Antibody [NBP2-15539] - Immunofluorescence analysis of methanol-fixed A431, using antibody at 1:500 dilution. Western Blot: BACE2 Antibody [NBP2-15539] - Sample (30 ug of whole cell lysate) A: Jurkat 7. 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Connectez-vous pour afficher 8 to 11 Days
$516.98
Détails
Humain Lapin Inconjugué FACS, WB The anti-BACE2 Ctr Pab (ABIN390067) is used in Western blot to detect BACE2 in HL60 cell lysate. Flow cytometric analysis of HL-60 cells using BACE2 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué EIA, WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human Serum; Lane2: Human Hela Cells. 100 μg Connectez-vous pour afficher 15 to 18 Days
$332.00
Détails
Cobaye Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Roussette (Chauve-souris) Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with BACE2 antibody ABIN214606 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Lung (formalin-fixed, paraffin-embedded) stained with BACE2 antibody ABIN214606 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Connectez-vous pour afficher 11 to 14 Days
$561.00
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails

anti-beta-Site APP-Cleaving Enzyme 2 Anticorps mieux référencés

  1. Human Polyclonal BACE2 Primary Antibody pour ELISA, WB - ABIN545630 : Barbiero, Benussi, Ghidoni, Alberici, Russo, Schettini, Pagano, Parati, Mazzoli, Nicosia, Signorini, Feudatari, Binetti: BACE-2 is overexpressed in Down's syndrome. dans Experimental neurology 2003 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal BACE2 Primary Antibody pour WB - ABIN550290 : Acquati, Accarino, Nucci, Fumagalli, Jovine, Ottolenghi, Taramelli: The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region. dans FEBS letters 2000 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal BACE2 Primary Antibody pour WB - ABIN550291 : Bennett, Babu-Khan, Loeloff, Louis, Curran, Citron, Vassar: Expression analysis of BACE2 in brain and peripheral tissues. dans The Journal of biological chemistry 2000 (PubMed)
    Show all 3 Pubmed References

Plus d’anticorps contre beta-Site APP-Cleaving Enzyme 2 partenaires d’interaction

Human beta-Site APP-Cleaving Enzyme 2 (BACE2) interaction partners

  1. the behavior of the flap tips during simulations is different between BACE1 and BACE2. The BACE1 active site cavity is more spacious as compared to that of BACE2. The analysis of 10S loop and 113S loop showed a similar trend to that of flaps, with the BACE1 loops being more flexible and less stable than those of BACE2

  2. RNA-seq evidence of biallelic expression of BACE2 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of BACE2 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals.

  3. Studies suggest that beta-Secretases BACE1/2 plays an important role in retinal homeostasis and that BACE upregulation in response to stress is a protective measure.

  4. Data suggest that the amino acid residues would be essential for selectivity of beta-amyloid precursor protein cleavage enzymes BACE1 and BACE2 functions and could be sites for the design of selective inhibitors targeting either BACE1 or BACE2.

  5. Data identified two novel genome-wide significant associations: 2-h plasma glucose and HKDC1, and fasting C-peptide and BACE2.

  6. BACE2 cleaves the integral membrane form of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain into endosomal precursors for the formation of amyloid fibrils and downstream melanosome morphogenesis.

  7. Inhibiting Chrna7 expression markedly stimulated the production of Abeta through the mechanism of increased expression of BACE1 and inhibited expression of BACE2 in SH-SY5Y cells.

  8. BACE2 overexpression in cultured cells was found to lower net amyloid ss-protein levels.

  9. The BACE2 distal promoter contains an activating cis-regulatory element that is responsive to Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells.

  10. All these data point to a role for BACE2 in the IRbeta trafficking and insulin signaling. In conclusion, BACE2 is hereby presented as an important enzyme in beta-cell function.

  11. Trransgenic BACE2 mice show increased anxiety-like behaviour along with increased numbers of noradrenergic neurones in the locus coeruleus.

  12. BACE1 likely accounts for most of the Abeta produced in the human brain, and that BACE2 activity is not a likely contributor

  13. BACE has a loose substrate specificity and that the substrate recognition site in BACE extends over several amino acids

  14. Specificity and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity

  15. the enzymatic properties of BACE2 were analyzed, including substrate specificity and pH range

  16. A novel aspartic protease gene, ALP56, is up-regulated in human breast cancer. ALP56 may be a useful target molecule in breast cancer treatment.

  17. BACE1 and BACE2 (a) are expressed in normal adult muscle at the postsynaptic domain of neuromuscular junctions, and in cultured human muscle; (b) accumulate in the form of plaque-like inclusions in myositis vacuolated and necrotic muscle fibers

  18. gamma-secretase cleavage of CT99 is a prerequisite for BACE-mediated processing at Abeta-34 site and therefore, BACE and gamma-secretase activity can be mutually dependent.

  19. antagonistic effect with beta-site amyloid precursor protein-cleaving enzyme 1 on beta-amyloid peptide production in cells

  20. Analysis revealed a 2.6-fold increase in BACE-2 mRNA levels in Down syndrome brains compared to the control group; increased secretion of BACE-2 by cultured fibroblasts and neural stem cells from Down syndrome patients was noted

Mouse (Murine) beta-Site APP-Cleaving Enzyme 2 (BACE2) interaction partners

  1. The absence of BACE2 ameliorates glucose tolerance defects induced by IAPP overexpression in the beta-cell and promotes beta-cell survival.

  2. the BACE1 homologue BACE2 processes PMEL to generate functional amyloids. BACE2 is highly expressed in pigment cells and Bace2(-/-) but not Bace1(-/-) mice display coat color defects, implying a specific role for BACE2 during melanogenesis

  3. non-redundant roles of BACE1/2 in ectodomain shedding with BACE1 regulating a broader and BACE2 a more distinct set of beta-cell-enriched substrates including two proteins of the seizure 6 protein family (SEZ6L and SEZ6L2).

  4. Tmem27 dimerization is a dynamic process involving Bace2

  5. Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass.

  6. The TgBACE2-APP mice showed deregulation of BACE2 expression levels that were significantly increased with respect to single TgBACE2 mice.

  7. Data show that BACE1 knockout mice display a complex phenotype, and a combined deficiency of BACE2 and BACE1 enhanced the bace1-/- lethality.

  8. BACE1 and BACE2 may act as alternative alpha-secretase-like proteases in proteolytic processing of IL-1R2 and APP

  9. The presence of BACE2 in secretory granules of beta cells suggests that it may play a role in diabetes-associated amyloidogenesis.

beta-Site APP-Cleaving Enzyme 2 (BACE2) profil antigène

Profil protéine

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BACE2

  • beta-site APP-cleaving enzyme 2 (BACE2) anticorps
  • beta-site APP-cleaving enzyme 2 (Bace2) anticorps
  • 1110059C24Rik anticorps
  • AEPLC anticorps
  • AI850424 anticorps
  • ALP56 anticorps
  • ARP1 anticorps
  • ASP1 anticorps
  • ASP21 anticorps
  • BAE2 anticorps
  • CDA13 anticorps
  • CEAP1 anticorps
  • DRAP anticorps

Protein level used designations for BACE2

56 kDa aspartic-like protease , Down syndrome region aspartic protease , aspartyl protease 1 , beta-secretase 2 , beta-site amyloid beta A4 precursor protein-cleaving enzyme 2 , memapsin-1 , membrane-associated aspartic protease 1 , theta-secretase , transmembrane aspartic proteinase Asp1 , ASP1 , asp 1 , beta-site APP cleaving enzyme 2 , beta-site amyloid precursor protein cleaving enzyme 2

GENE ID SPECIES
25825 Homo sapiens
56175 Mus musculus
288227 Rattus norvegicus
100342092 Oryctolagus cuniculus
100720853 Cavia porcellus
100517374 Sus scrofa
478418 Canis lupus familiaris
534774 Bos taurus
418526 Gallus gallus
101102027 Ovis aries
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