gamma-aminobutyric Acid (GABA) Receptor, rho 1 Protéines (GABRR1)

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. De plus, nous expédions gamma-aminobutyric Acid (GABA) Receptor, rho 1 Anticorps (59) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
GABRR1 2569 P24046
Rat GABRR1 GABRR1 29694  
GABRR1 14408 P56475
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Top gamma-aminobutyric Acid (GABA) Receptor, rho 1 Protéines sur anticorps-enligne.fr

Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,493.38
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Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
Détails

GABRR1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine) ,
,

Plus protéines pour gamma-aminobutyric Acid (GABA) Receptor, rho 1 (GABRR1) partenaires d'interaction

Human gamma-aminobutyric Acid (GABA) Receptor, rho 1 (GABRR1) interaction partners

  1. GABAergic genes interacting with parenting in adolescent depressive symptoms: GABRR1 X perceived parental support interaction.

  2. Study determined that levels of GABAA receptors rho1 and rho2 are not altered in the cerebellum of WT and rho1 knockin mice. In addition, findings show that mutation of the inhibitory ethanol site in rho1 does not alter normal channel function, but is important for the development of acute tolerance to ethanol-induced motor impairment.

  3. The most common polymorphisms in the GABRR genes seemed to be not associated with the risk for migraine in Caucasian Spanish people, although one of them (GABRR1 rs1186902) shows a statistically significant association with the age of onset of migraine.

  4. Thr244 of rho1 GABAC Receptors is an important residue for channel activation as it forms a H-bond with agonists, initiating the conformational changes required for priming of the receptor and stabilizes the open conformation (review).

  5. Both GABAAalpha1 and GABAArho1 mRNAs and proteins were identified in cultured retinal pigment epithelial cells; antibody staining was mainly localized to the cell membrane and was also present in the cytoplasm but not in the nucleus.

  6. Data indicate that all compounds from the study exhibited increased selectivity for GABAC.

  7. The function of GABA(C) receptors can be enhanced by nitric oxide acting at the extracellular Cys-loop.

  8. evidence supporta the involvement of histaminergic and gamma-aminobutyric acidergic mechanisms in the etiology of TS and show an overlap of rare CNVs in TS and autism spectrum disorder.

  9. found no significant differences in either the frequencies of the GABRR1-M26V, GABRR1- H27R, GABRR2-T455M, and GABRR3-Y205X genotypes or in the frequencies of the allelic variants of these polymorphisms in patients with essential tremor

  10. GABRR1 is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features

  11. GABRR1 and GABRR2 encode the GABA-A receptor subunits rho1 and rho2 and are associated with alcohol dependence

  12. Data show that GABArho1 can tolerate removal of several residues that form the fourth transmembrane segment up to a critical point, signaled by W475, beyond which the mutant protein is translated but does not form functional receptors.

  13. examination of receptor modulation by divalent cations

  14. Tyr-102 is a component of the GABA binding domain and it might be important for coupling agonist binding to channel opening

  15. a single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism

  16. a complete model of the GABA(C) receptor binding pocket was proposed and discussed in comparison with the GABA(A) receptor binding pocket

  17. GABA receptor subunit rho-1 effectively altered gene expression through its interaction with the cellular retinoic acid binding protein pathway

  18. Charge selectivity of the anionic rho1 GABA receptor can be influenced by the introduction of glutamates, one at a time, over an 8-amino acid stretch (-2' to 5') in the proposed intracellular end of TM2 and the TM1-TM2 intracellular linker.

  19. Results imply that the M3M4 loop is not essential for GABA rho1 receptor assembly and function and suggest that the cytoplasmic domain may fold as an independent module from the transmembrane and extracellular domains.

  20. Structural determinants for antagonists that distinguish the GABRR1 receptor from GABA-A receptors are reported.

Pig (Porcine) gamma-aminobutyric Acid (GABA) Receptor, rho 1 (GABRR1) interaction partners

  1. The most notable difference found in the pig GABArho1 receptor was the absence of a stretch of 17 amino acids near the amino terminus (R41-V58) conserved in the rat and the human.

Mouse (Murine) gamma-aminobutyric Acid (GABA) Receptor, rho 1 (GABRR1) interaction partners

  1. GABACR antagonists differed in their effects on nSTR and PhNR; antagonists with GABAB agonist properties enhanced light-driven responses whereas 2-AEMP did not.

  2. GABArho has a role in the bicuculline-insensitive component of GFAP+ cells of cerebellum

  3. Ethanol action on GABAA receptors containing rho1/rho2 subunits may be important for specific effects of ethanol in vivo.

  4. Identification of a fragment flanking the GABArho1 gene promoter paves the way for studies of molecular elements that control GABArho1 transcription and regulate its expression during retinal development.

  5. GABA(C) receptors play a general role for the control of neuronal excitability in subcortical visual pathways.

  6. activation of peripheral GABA-Rs may provide a new modality to modulate T cell, B cell, and APC activity and help ameliorate RA and other inflammatory diseases.

  7. the GABA receptor/channel rho 1 subunit plays an important role in modulating spinal cord pain transmission functions in vivo

  8. GABA(C) receptors and protein phosphatase 1 (PP1) simultaneously bind to different domains of PNUTS, the targeting subunit of PP1.

  9. In GABA(C) rho1 Null stratum griseum superficiale (SGS) cells, inhibitory postsynaptic currents were shorter in duration and their excitatory postsynaptic currents were longer, indicating that a slow GABA(C)R-mediated inhibitory component was reduced.

Profil protéine gamma-aminobutyric Acid (GABA) Receptor, rho 1 (GABRR1)

Profil protéine

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GABRR1

  • gamma-aminobutyric acid type A receptor rho1 subunit (GABRR1)
  • gamma-aminobutyric acid type A receptor rho 1 subunit (Gabrr1)
  • gamma-aminobutyric acid (GABA) C receptor, subunit rho 1 (Gabrr1)
  • GABA-C Protéine

Protein level used designations for GABRR1

GABA(A) receptor subunit rho-1 , GABA(A) receptor, rho 1 , GABA(C) receptor , bA135P14.1 (gamma-aminobutyric acid (GABA) receptor, rho 1) , gamma-aminobutyric acid (GABA) A receptor, rho-1 , gamma-aminobutyric acid (GABA) receptor, rho 1 , gamma-aminobutyric acid receptor subunit rho-1 , gamma-aminobutyric acid (GABA-A) receptor subunit rho 1 , gamma-aminobutyric acid (GABA-A) receptor, subunit rho 1 , gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1 , gamma-aminobutyric acid A receptor, rho 1

GENE ID SPECIES
2569 Homo sapiens
481917 Canis lupus familiaris
521180 Bos taurus
29694 Rattus norvegicus
100153555 Sus scrofa
14408 Mus musculus
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