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MPPED2 likely encodes a metallophosphoesterase. De plus, nous expédions MPPED2 Anticorps (55) et beaucoup plus de produits pour cette protéine.
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Findings indicate that epigenetic alterations of MPPED2 promoter region appear sequentially during the colorectal neoplastic progression.
The overexpression of Mpped2 improves survival rate, substantially impairs tumor growth and induces neuronal differentiation.
The structures of MPPED2 and two mutants show that the poor activity of MPPED2 is not only a consequence of the substitution of an active-site histidine residue by glycine but also due to binding of AMP or GMP to the active site.
This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described.
metallophosphoesterase MPPED2 , fetal brain protein 239 , metallophosphoesterase domain-containing protein 2 , 239FB , fetal brain protein 239 homolog , putative C11orf8 homolog , metallophosphoesterase domain containing 2